Pediatric Gastroenterology, Hepatology & Nutrition

  • 제27권4호
  • /
  • Pages.206-214
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  • 2024
  • /
  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Prevalence of Inflammatory Bowel Disease Unclassified, as Estimated Using the Revised Porto Criteria, among Korean Pediatric Patients with Inflammatory Bowel Disease

  • Sung Hee Lee (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Minsoo Shin (Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine) ;
  • Seo Hee Kim (Department of Pediatrics, Chonnam National University Children's Hospital, Chonnam National University College of Medicine) ;
  • Seong Pyo Kim (Interdisciplinary Program of Medical Informatics, Seoul National University College of Medicine) ;
  • Hyung-Jin Yoon (Department of Biomedical Engineering, Seoul National University College of Medicine) ;
  • Yangsoon Park (Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jaemoon Koh (Department of Pathology, Seoul National University College of Medicine) ;
  • Seak Hee Oh (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Jae Sung Ko (Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine) ;
  • Jin Soo Moon (Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine) ;
  • Kyung Mo Kim (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine)
  • 투고 : 2024.03.27
  • 심사 : 2024.05.06
  • 발행 : 2024.07.15
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초록

Purpose: Few studies have reported the prevalence of inflammatory bowel disease unclassified (IBDU) among Korean pediatric IBD (PIBD) population. To address this gap, we used two tertiary centers and nationwide population-based healthcare administrative data to estimate the prevalence of Korean pediatric IBDU at the time of diagnosis. Methods: We identified 136 patients aged 2-17 years with newly diagnosed IBD (94 Crohn's disease [CD] and 42 ulcerative colitis [UC]) from two tertiary centers in Korea between 2005 and 2017. We reclassified these 136 patients using the revised Porto criteria. To estimate the population-based prevalence, we analyzed Korean administrative healthcare data between 2005 and 2016, which revealed 3,650 IBD patients, including 2,538 CD and 1,112 UC. By extrapolating the reclassified results to a population-based dataset, we estimated the prevalence of PIBD subtypes. Results: Among the 94 CD, the original diagnosis remained unchanged in 93 (98.9%), while the diagnosis of one (1.1%) patient was changed to IBDU. Among the 42 UC, the original diagnosis remained unchanged in 13 (31.0%), while the diagnoses in 11 (26.2%), 17 (40.5%), and one (2.4%) patient changed to atypical UC, IBDU, and CD, respectively. The estimated prevalences of CD, UC, atypical UC, and IBDU in the Korean population were 69.5%, 9.4%, 8.0%, and 13.1%, respectively. Conclusion: This study is the first in Korea to estimate the prevalence of pediatric IBDU. This prevalence (13.1%) aligns with findings from Western studies. Large-scale prospective multicenter studies on PIBDU are required to examine the clinical features and outcomes of this condition.

키워드

과제정보

We extend our heartfelt gratitude to Drs. Dan Turner and Liron Birimberg-Schwartz for providing their meticulous guidance and invaluable insights in interpreting and applying the revised Porto criteria to Korean patients.

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