Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Anti-inflammatory, Anti-aging, and Sebum Inhibitory Effects of Osmanthus fragrans Flower Extract

목서 꽃 추출물의 항염, 항노화 및 피지 억제 효능

  • Hyung-Min Kim (Basic Research & Innovation Division, AMOREPACIFIC R&I Center) ;
  • Yeon Su Jeong (Basic Research & Innovation Division, AMOREPACIFIC R&I Center) ;
  • Sehyun Kim (Basic Research & Innovation Division, AMOREPACIFIC R&I Center) ;
  • Jeong Hun Cho (Basic Research & Innovation Division, AMOREPACIFIC R&I Center) ;
  • Yong Deog Hong (Basic Research & Innovation Division, AMOREPACIFIC R&I Center) ;
  • Won-Seok Park (Basic Research & Innovation Division, AMOREPACIFIC R&I Center)
  • 김형민 (아모레퍼시픽 R&I 센터) ;
  • 정연수 (아모레퍼시픽 R&I 센터) ;
  • 김세현 (아모레퍼시픽 R&I 센터) ;
  • 조정훈 (아모레퍼시픽 R&I 센터) ;
  • 홍용덕 (아모레퍼시픽 R&I 센터) ;
  • 박원석 (아모레퍼시픽 R&I 센터)
  • Received : 2024.05.28
  • Accepted : 2024.06.25
  • Published : 2024.06.30
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Abstract

In this study, we aimed to determine the various effects of Osmanthus fragrans (O. fragrans) flower extract on the skin in order to utilize it as a cosmetic material. For this purpose, Osmanthus fragrans flower extract (OFFE) of Jeju Island was prepared and used in the experiment. The experiments were evaluated by the quantitative real-time polymerase chain reaction (qRT-PCR) and lipid droplet staining assay. First, the OFFE decreased the gene expressions of three representative pro-inflammatory cytokines (IL-8, IL-6, and IL-1α) and an inflammation-related enzyme, PTGS2 induced by poly I:C in epidermal keratinocytes. In addition, the OFFE increased the gene expression levels of collagen (COL1A1) and elastin (ELN) in dermal fibroblasts. Further, the OFFE showed the inhibitory effect in sebum production by linoleic acid in sebocytes. Therefore, from this study, it is expected that OFFE can be used as a natural cosmetic material for anti-inflammatory, anti-aging, and sebum inhibitory efficacy.

본 연구에서는 목서(Osmanthus fragrans, O. fragrans) 꽃 추출물을 화장품 소재로 활용하기 위해 피부에 대한 다양한 효능을 확인하고자 하였다. 이를 위해 제주산 목서 꽃 추출물(O. fragrans flower extract, OFFE)을 제조하여 실험에 이용하였다. 실험은 실시간 중합효소 연쇄반응인 qRT-PCR과 lipid droplet 염색법으로 평가하였다. 먼저 OFFE는 표피 각질세포에서 poly I:C로 유도된 3 종의 대표적인 전염증성 사이토카인 (IL-8, IL-6, IL-1α)과 염증 관련 효소인 PTGS2의 유전자 발현을 감소시켰다. 또한 OFFE는 진피 섬유아세포에서 콜라겐(COL1A1)과 엘라스틴(ELN) 유전자 발현을 증가시켰다. 더 나아가 OFFE는 피지세포에서 linoleic acid에 의해 유도된 피지 생성을 억제하는 효능 보여주었다. 따라서 본 연구를 통해 OFFE은 항염, 항노화, 그리고 피지억제 효능을 위한 천연 화장품 소재로써 적용이 가능할 것으로 기대된다.

Keywords

Acknowledgement

본 연구를 위해 목서 꽃의 수급과 시험 시료 준비과정을 협업한 대봉엘에스(주)에 감사드립니다.

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