Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effects of Panax species and their bioactive components on allergic airway diseases

  • Dahee Shim (Industry-Academic Cooperation Foundation, Hallym University) ;
  • Yeeun Bak (Department of Biomedical Science, Hallym University College of Medicine) ;
  • Han-Gyu Choi (Department of Microbiology and Medical Science, College of Medicine, Chungnam National University) ;
  • Seunghyun Lee (Department of Microbiology, Institute for Immunology and Immunological Disease, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine) ;
  • Sang Chul Park (Department of Otorhinolaryngology-Head and Neck Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
  • Received : 2023.12.28
  • Accepted : 2024.04.17
  • Published : 2024.07.01
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Abstract

Panax species include Panax ginseng Meyer, Panax quinquefolium L., Panax notoginseng, Panax japonicum, Panax trifolium, and Panax pseudoginseng, which contain bioactive components (BCs) such as ginsenosides and polysaccharides. Recently, growing evidence has revealed the pharmacological effects of Panax species and their BCs on allergic airway diseases (AADs), including allergic asthma (AA) and allergic rhinitis (AR). AADs are characterized by damaged epithelium, sustained acquired immune responses with enforced Th2 responses, allergenspecific IgE production, and enhanced production of histamine and leukotrienes by activated mast cells and basophils. In this review, we summarize how Panax species and their BCs modulate acquired immune responses involving interactions between dendritic cells and T cells, reduce the pro-inflammatory responses of epithelial cells, and reduce allergenic responses from basophils and mast cells in vitro. In addition, we highlight the current understanding of the alleviative effects of Panax species and their BCs against AA and AR in vivo. Moreover, we discuss the unmet needs of research and considerations for the treatment of patients to provide basic scientific knowledge for the treatment of AADs using Panax species and their BCs.

Keywords

Acknowledgement

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (2020R1I1A3067369). This research was supported by Hallym University Research Fund and Korean Society of Ginseng in 2023.

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