Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Effects of Cell-Cell Contact on Vibration Loading-induced Browning of 3T3-L1 Preadipocytes

진동 자극을 통한 3T3-L1 지방전구세포의 갈변화에서 세포 간 접촉의 영향

  • Heejin Noh (Department of Biomedical Engineering, Yonsei University) ;
  • Yong Chan Jung (Department of Biomedical Engineering, Yonsei University) ;
  • Gayoung Kim (Department of Biomedical Engineering, Yonsei University) ;
  • Eunyeong Moon (Department of Biomedical Engineering, Yonsei University) ;
  • Eun Mi Lee (Department of Biomedical Engineering, Yonsei University) ;
  • Chi Hyun Kim (Department of Biomedical Engineering, Yonsei University)
  • 노희진 (연세대학교 보건과학대학 의공학부) ;
  • 정용찬 (연세대학교 보건과학대학 의공학부) ;
  • 김가영 (연세대학교 보건과학대학 의공학부) ;
  • 문은영 (연세대학교 보건과학대학 의공학부) ;
  • 이은미 (연세대학교 보건과학대학 의공학부) ;
  • 김지현 (연세대학교 보건과학대학 의공학부)
  • Received : 2023.12.29
  • Accepted : 2024.02.19
  • Published : 2024.02.28
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Abstract

The prevalence of obesity and its complications is steadily increasing worldwide. It is essential to understand cellular level metabolism and microenvironment to treat diseases related to lipid metabolism. Mechanical loading can activate signaling pathway by stimulating cells, especially vibration loading known to inhibit adipogenesis, so it has been studied as a treatment for obesity. Also, vibration loading can affect the inside of the human body non-invasively. Another clue to reducing adipose tissue is browning, which means that white adipocytes changes to brown adipocyte. In this study, we design and developed a device that that can control cell-cell contact, and vibration simulation device. Using these two devices, we investigated responses of cells to vibration loading. Protein expression associated with browning and adipogenesis were analyzed. In conclusion, vibration loading can be transmitted through cell contact and loading applied to the cells can induce browning and inhibit adipogenesis of preadipocytes. These results suggest the possibility that vibrations could be a treatment for obesity.

Keywords

References

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