Acknowledgement
This manuscript is based on a part of the first author's master's thesis from Chungnam National University.
References
- Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. The New England Journal of Medicine. 2020;382(8):727-733. https://doi.org/10.1056/NEJMoa2001017
- Korea Disease Control and Prevention Agency. COVID-19 for health care use. Symptoms and course [Internet]. Cheongju: Korea Disease Control and Prevention Agency; 2024 [cited 2024 Apr 17]. Available from: https://ncv.kdca.go.kr/pot/www/CVID19/CVID19_INFO/DFNTN.jsp
- Torres Acosta MA, Singer BD. Pathogenesis of COVID-19- induced ARDS: implications for an ageing population. European Respiratory Journal. 2020;56(3):2002049. https://doi.org/10.1183/13993003.02049-2020
- Centers for Disease Control and Prevention. People with certain medical conditions [Internet]. Atlanta: Centers for Disease Control and Prevention; 2024 [cited 2024 Apr 17]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html
- Soeroto AY, Soetedjo NN, Purwiga A, Santoso P, Kulsum ID, Suryadinata H, et al. Effect of increased BMI and obesity on the outcome of COVID-19 adult patients: a systematic review and meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14(6):1897-1904. https://doi.org/10.1016/j.dsx.2020.09.029
- Suleyman G, Fadel RA, Malette KM, Hammond C, Abdulla H, Entz A, et al. Clinical characteristics and morbidity associated with coronavirus disease 2019 in a series of patients in metropolitan Detroit. JAMA Network Open. 2020;3(6): e2012270. https://doi.org/10.1001/jamanetworkopen.2020.12270
- Hernandez-Galdamez DR, Gonzalez-Block MA, Romo-Duenas DK, Lima-Morales R, Hernandez-Vicente IA, Lumbreras-Guzman M, et al. Increased risk of hospitalization and death in patients with COVID-19 and pre-existing noncommunicable diseases and modifiable risk factors in Mexico. Archives of Medical Research. 2020;51(7):683-689. https://doi.org/10.1016/j.arcmed.2020.07.003
- Ho FK, Celis-Morales CA, Gray SR, Katikireddi SV, Niedzwiedz CL, Hastie C, et al. Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK biobank prospective cohort study. British Medical Journal Open. 2020;10(11):e040402. https://doi.org/10.1136/bmjopen2020-040402
- Demeulemeester F, de Punder K. Obesity as a risk factor for severe COVID-19 and complications: a review. Cells. 2021; 10(4):933. https://doi.org/10.3390/cells10040933
- De Heredia FP, Gomez-Martinez S. Obesity, inflammation and the immune system. Proceedings of the Nutrition Society. 2012;71(2):332-338. https://doi.org/10.1017/S0029665112000092
- Tang CH, Lu DY, Yang RS, Tsai HY, Kao MC, Fu WM, et al. Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. The Journal of Immunology. 2007;179(2):1292-1302. https://doi.org/10.4049/jimmunol.179.2.1292
- Chiappetta S, Sharma AM. COVID-19 and the role of chronic inflammation in patients with obesity. International Journal of Obesity. 2020;44(8):1790-1792. http://doi.org/10.1038/s41366-020-0597-4
- Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Seminars in Immunopathology. 2017;39(5):529-539. https://doi.org/10.1007/s00281-017-0629-x
- Fehr AR, Channappanavar R. Middle east respiratory syndrome: emergence of a pathogenic human coronavirus. Annual Review of Medicine. 2017;68:387-399. https://doi.org/10.1146/annurev-med-051215-031152
- Paquette SG, Banner D, Zhao Z, Fang Y, Huang SS, Leόn AJ, et al. Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection. PLoS One. 2012;7(6):e38214. https://doi.org/10.1371/journal.pone.0038214
- Booth A, Reed AB, Ponzo S, Yassaee A, Aral M, Plans D, et al. Population risk factors for severe disease and mortality in COVID-19: a global systematic review and meta-analysis. PLoS One. 2021;16(3):e0247461. https://doi.org/10.1371/journal.pone.0247461
- Morris AE, Stapleton RD. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007;131(2):342-348. https://doi.org/10.1378/chest.06-1709
- Trnacevic A, Mujkanovic A, Al-Salloum N, Sakusic A, Trnacevic E, Jusufovic E, et al. COVID-19 in northeast bosnia and herzegovina and patient's length of hospitalization. BMC Infectious Diseases. 2021;21(1):367. https://doi.org/10.1186/s12879-021-06034-6
- Argenziano MG, Bruce SL, Slater CL, Tiao JR, Baldwin MR, Barr RG, et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in new york: retrospective case series. British Medical Journal. 2020;369:m1996. https://doi.org/10.1136/bmj.m1996
- Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. Covid-19 in critically ill patients in the seattle region - case series. The New England Journal of Medicine. 2020;382(21):2012-2022. https://doi.org/10.1056/NEJMoa2004500
- Korean Society for the Study of Obesity. Diagnosis and evaluation of obesity [Internet]. Seoul: Korean Society for the Study of Obesity; 2024 [cited 2022 May 2]. Available from: http://general.kosso.or.kr/html/?pmode= obesityDiagnosis
- Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology. 2011;11(2):85-97. https://doi.org/10.1038/nri2921
- Korea Disease Control and Prevention Agency. Protocol for investigating suspected COVID-19 infection (local government). 9-5 version [Internet]. Cheongju: Ministry of Health and Welfare; 2024 [cited 2022 May 2]. Available from: http://www.cdc.go.kr/board/board.es?mid = a20507020000&-bid= 0019
- Zeng J, Liu X, Wang S, Yang S, Jia W, Han K, et al. The association between BMI and metabolically unhealthy status with COVID-19 mortality: based on 3019 inpatients from Wuhan, China. Nutrition, Metabolism & Cardiovascular Diseases. 2021;31(11):3219-3226. https://doi.org/10.1016/j.numecd.2021.07.030
- Hamer M, Kivimaki M. Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: a community-based cohort study of 387,109 adults in UK. Brain, Behavior, and Immunity. 2020;87:184-187. https://doi.org/10.1016/j.bbi.2020.05.059
- Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet. 2020;395(10223):507-513. https://doi.org/10.1016/S0140-6736(20)30211-7
- Potere N, Batticciotto A, Vecchie A, Porreca E, Cappelli A, Abbate A, et al. The role of IL-6 and IL-6 blockade in COVID-19. Expert Review of Clinical Immunology. 2021;17(6):601-618. https://doi.org/10.1080/1744666X.2021.1919086
- Bello S, Lasierra AB, Lopez-Vergara L, de Diego C, Torralba L, de Gopegui PR, et al. IL-6 and cfDNA monitoring throughout COVID-19 hospitalization are accurate markers of its outcomes. Respiratory Research. 2023;24(1):125. https://doi.org/10.1186/s12931-023-02426-1
- Gil S, Jacob Filho W, Shinjo SK, Ferriolli E, Busse AL, Avelino-Silva TJ, et al. Muscle strength and muscle mass as predictors of hospital length of stay in patients with moderate to severe COVID-19: a prospective observational study. Journal of Cachexia, Sarcopenia and Muscle. 2021;12(6):1871-1878. https://doi.org/10.1002/jcsm.12789
- Rees EM, Nightingale ES, Jafari Y, Waterlow NR, Clifford S, Pearson CAB, et al. COVID-19 length of hospital stay: a systematic review and data synthesis. BMC Medicine. 2020;18(1):270. https://doi.org/10.1186/s12916-020-01726-3
- Simonnet A, Chetboun M, Poissy J, Raverdy V, Noulette J, Duhamel A, et al. High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity. 2020;28(7):1195-1199. https://doi.org/10.1002/oby.22831
- Jaisinghani P, Kumar R. Obesity and viral infections. Gastroenterology Clinics of North America. 2023;52(2):393-402. https://doi.org/10.1016/j.gtc.2023.03.012
- Wehbe Z, Hammoud SH. Molecular and biological mechanisms underlying gender differences in COVID-19 severity and mortality. Frontiers in Immunology. 2021;12:659339. https://doi.org/10.3389/fimmu.2021.659339
- Le Guen CL, King NA. COVID-19 patients with obesity at risk for worse outcomes despite younger age and fewer inflammatory derangements. Surgery for Obesity and Related Diseases. 2021;17(10):1722-1730. https://doi.org/10.1016/j.soard.2021.06.006
- Hu B, Guo H. Characteristics of SARS-CoV-2 and COVID-19. Nature Reviews Microbiology. 2021;19(3):141-154. https://doi.org/10.1038/s41579-020-00459-7
- Rodriguez-Morales AJ, Cardona-Ospina JA, Gutierrez-Ocampo E, Villamizar-Pena R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Medicine and Infectious Disease. 2020;34:101623. https://doi.org/10.1016/j.tmaid.2020.101623
- Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2020;94:91-95. https://doi.org/10.1016/j.ijid.2020.03.017
- Clark A, Jit M, Warren-Gash C, Guthrie B, Wang HHX, Mercer SW, et al. Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study. The Lancet Global Health. 2020;8(8):e1003-e1017. https://doi.org/10.1016/S2214-109X(20)30264-3