한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)

  • 제37권1호
  • /
  • Pages.42-56
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  • 2024
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  • 1738-6640(pISSN)
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  • 2234-4020(eISSN)
대한한방안이비인후피부과학회 (The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology)
권호 표지
DOI QR코드

DOI QR Code

소아청소년기 중이염의 천연물 의약품 치료 : 무작위 대조군 연구에 대한 문헌 고찰

Herbal Medicines for the Treatment of Otitis Media in Children : A Literature Review of Randomised Controlled Trials

  • 홍다희 (경희대학교 일반대학원 임상한의학과) ;
  • 김민희 (경희대학교 한의과대학 한방안이비인후피부과 교실)
  • Da Hee Hong (Department of Clinical Korean Medicine, Graduate school, Kyung Hee University ) ;
  • Min Hee Kim (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
  • 투고 : 2024.01.17
  • 심사 : 2024.02.01
  • 발행 : 2024.02.25
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초록

Objectives : The purpose of this literature review is to analyze herbal medicine's efficacy in pediatric otitis media. Methods : Six databases(Pubmed, CNKI, RISS, KISS, KCI, OASIS) were used to search randomized controlled trials related to pediatric otitis media until October 2023. Total nine studies written in Korean, English, Chinese, and German were selected and analyzed. Results : Recurrent otitis media was treated with Kami-hyunggyeyungyo-tang, Echinacea purpurea, and Sipjeondaebo-tang. For acute otitis media, Otovowen and Sopunghaedok capsule were administered, while Oryung-san, Chongyi-tang, and Changyija-san were used for otitis media with effusion. Glycyrrhizae Radix(甘草) and Cnidii Rhizome(川芎) were the most frequently used. Objective measures showed superior effects in the herbal medicine group for otoscopic examination, impedance test, audiometry, and fever. Sipjeondaebo-tang exhibited significant efficacy in recurrent otitis media treatment, possibly related to warming-interior medicine(溫裏藥) or blood-invigorating medicine(血分藥). Conclusion : Analyzing studies revealed herbal medicine's superiority for pediatric otitis media over conventional approaches.

키워드

참고문헌

  1. Lee HJ, Park SK, Choi KY, Park SE, Chun YM, Kim KS, et al. Korean clinical practice guidelines: otitis media in children. J Korean Med Sci. 2012;27(8):835-48.  https://doi.org/10.3346/jkms.2012.27.8.835
  2. Rosenfeld RM. Antibiotic Prophylaxis for Recurrent Otitis Media: Advanced Therapy of Otitis Media: PMPH-USA. 2004:117-121. 
  3. Paradise J, Bernard B, Colborn D, Smith C, Rockette H. Otitis media with effusion (OME): highly prevalent and often the forerunner of acute otitis media (AOM) during the first year of life. Pediatr Res. 1993;33:121A. 
  4. Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013;131(3):e964-99.  https://doi.org/10.1542/peds.2012-3488
  5. Jang SH. Diagnosis and Management of Acute Otitis Media and Otitis Media With Effusion. Clinical and Experimental Pediatrics. 2005;48(12):1283-94. 
  6. Rosenfeld RM, Shin JJ, Schwartz SR, Coggins R, Gagnon L, Hackell JM, et al. Clinical Practice Guideline: Otitis Media with Effusion (Update). Otolaryngol Head Neck Surg. 2016;154(1 Suppl):1-41.  https://doi.org/10.1177/0194599815616780
  7. Korean Otologic Society. Korean clinical practice guideline: otitis media in children 2014 [Internet]. Seoul: Korean Medical Guideline Information Center; 2014[cited 2015 Jul 2]. Available from:URL :https://www.otologicalsociety.or.kr/member/file/2014_01.pdf 
  8. Venekamp RP, Sanders SL, Glasziou PP, Rovers MM. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2023;11(11):1-83.  https://doi.org/10.1002/14651858.CD000219.pub5
  9. Thompson PL, Gilbert RE, Long PF, Saxena S, Sharland M, Wong ICK. Effect of Antibiotics for Otitis Media on Mastoiditis in Children: A Retrospective Cohort Study Using the United Kingdom General Practice Research Database. Pediatrics. 2009;123(2):424-30.  https://doi.org/10.1542/peds.2007-3349
  10. Teele DW, Klein JO, Rosner B. Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. The Journal of Infectious Diseases. 1989;160(1):83-94.  https://doi.org/10.1093/infdis/160.1.83
  11. Vergison A, Dagan R, Arguedas A, Bonhoeffer J, Cohen R, Dhooge I, et al. Otitis media and its consequences: beyond the earache. The Lancet Infectious Diseases. 2010;10(3):195-203.  https://doi.org/10.1016/S1473-3099(10)70012-8
  12. Schilder AG, Chonmaitree T, Cripps AW, Rosenfeld RM, Casselbrant ML, Haggard MP, et al. Otitis media. Nat Rev Dis Primers. 2016;2(1):1-18.  https://doi.org/10.1038/nrdp.2016.63
  13. Elicora S, Ozturk M, Sevinc R, Derin S, Dinc AE, Erdem D. Risk factors for otitis media effusion in children who have adenoid hypertrophia. Int J Pediatr Otorhinolaryngol. 2015;79 (3):374-7.  https://doi.org/10.1016/j.ijporl.2014.12.030
  14. Zernotti ME, Pawankar R, Ansotegui I, Badellino H, Croce JS, Hossny E, et al. Otitis media with effusion and atopy: is there a causal relationship? World Allergy Organ J. 2017;10(1):37. 
  15. Son MJ, Kim YE, Song YI, Kim YH. Herbal medicines for treating acute otitis media: A systematic review of randomised controlled trials. Complement Ther Med. 2017;35:133-9.  https://doi.org/10.1016/j.ctim.2017.11.001
  16. Son MJ, Choi S, Kim YE, Kim YH. Herbal medicines for the treatment of otitis media with effusion: a systematic review of randomised controlled trials. BMJ Open. 2016;6(11):1-11.  https://doi.org/10.1136/bmjopen-2016-011250
  17. Wahl RA, Aldous MB, Worden KA, Grant KL. Echinacea purpurea and osteopathic manipulative treatment in children with recurrent otitis media: a randomized controlled trial. BMC Complement Altern Med. 2008;8:1-9.  https://doi.org/10.1186/1472-6882-8-1
  18. Yang MR, Jin KS, Lee HJ, Kwon MW, Park EJ. A Clinical Study on the Therapeutic Effect of Kamihyunggyeyungyotang for Pediatric Recurrent Otitis Media with Effusion. The journal of pediatrics of Korean medicine. 2001;15(2):87-100. 
  19. Jeong HJ, Hong SH, Kim SC, Park EJ, Jang CH, Kim KS, et al. Effects of Allergina on the Treatment of Otitis Media with Effusions. Inflammation. 2002;26(2):89-95.  https://doi.org/10.1023/A:1014888328482
  20. Zhang YK, Dong M. Clinical observation of Wulingsan addition and subtraction combined with positive and negative pressure of tympanic membrane in the treatment of secretory otitis media. J Community Med. 2020;18(06):436-40. 
  21. Ito M, Maruyama Y, Kitamura K, Kobayashi T, Takahashi H, Yamanaka N, et al. Randomized controlled trial of juzen-taiho-to in children with recurrent acute otitis media. Auris Nasus Larynx. 2017;44(4):390-7.  https://doi.org/10.1016/j.anl.2016.10.002
  22. Wustrow TP. Naturopathic therapy for acute otitis media. An alternative to the primary use of antibiotics. Hno. 2005;53(8):728-34.  https://doi.org/10.1007/s00106-004-1185-y
  23. Zhang H. Clinical Observation on Shufeng Jiedu Capsule in the Treatment of Acute Otitis Media in Children. Journal of Emergency in Traditional Chinese Medicine. 2017;26(02):288-91. 
  24. Wang NB, Zhang X, She HH, Wng K. A clinical study on the traditional Chinese medicine pattern differentiation and treatment of secretory otitis media in children. Chinese Journal of Otorhinolaryngology in Integrative Medicine. 2020;28(06):458-60. 
  25. Xu XQ, Xu SS, Cao YQ. Analysis of Therapeutic Effect of Chinese Medicine Sequential Therapy on Pediatric Secretory Otitis Media. New Chinese Medicine. 2022;54(09):123-5. 
  26. Cristina BN, Florin B, Jurca T, et al. Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants (Basel). 2022;11(9):1-20.  https://doi.org/10.3390/plants11091244
  27. Aucoin M, Cooley K, Saunders PR, Care J, Anheyer D, Medina DN, et al. The effect of Echinacea spp. on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: A rapid review. Adv Integr Med. 2020;7(4):203-17.  https://doi.org/10.1016/j.aimed.2020.07.004
  28. Patel JA, Nair S, Revai K, Grady J, Saeed K, Matalon R, et al. Association of proinflammatory cytokine gene polymorphisms with susceptibility to otitis media. Pediatrics. 2006;118(6):2273-9.  https://doi.org/10.1542/peds.2006-0764
  29. Revai K, Patel JA, Grady JJ, Nair S, Matalon R, Chonmaitree T. Association between cytokine gene polymorphisms and risk for upper respiratory tract infection and acute otitis media. Clin Infect Dis. 2009;49(2):257-61.  https://doi.org/10.1086/599833
  30. Skotnicka B, Hassmann E. Proinflammatory and immunoregulatory cytokines in the middle ear effusions. Int J Pediatr Otorhinolaryngol. 2008;72(1):13-7.  https://doi.org/10.1016/j.ijporl.2007.09.005
  31. Nokso-Koivisto J, Chonmaitree T, Jennings K, Matalon R, Block S, Patel JA. Polymorphisms of immunity genes and susceptibility to otitis media in children. PLoS One. 2014;9(4):1-7.  https://doi.org/10.1371/journal.pone.0093930
  32. Nieters A, Brems S, Becker N. Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population. Hum Genet. 2001;108(3):241-8.  https://doi.org/10.1007/s004390100464
  33. Zhang XY, Feng CL, Meng YF, Du JC, Cen JS, Wei YJ. Effects of Yupingfeng Powder and Guomin Decoction Combined with Zhisou Powder on Lung Injury Rats Caused by Imbalance of Th17/Treg Induced by PM2.5. Chinese Journal of Information on Traditional Chinese Medicine. 2017;24(04):45-9.