Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Anti-Inflammatory Herbal Extracts and Their Drug Discovery Perspective in Atopic Dermatitis

  • Jae-Won Lee (Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Eun-Nam Kim (College of Pharmacy, Chungnam National University) ;
  • Gil-Saeng Jeong (College of Pharmacy, Chungnam National University)
  • Received : 2023.05.30
  • Accepted : 2023.08.01
  • Published : 2024.01.01
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Abstract

Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. There is accumulating evidence demonstrating the beneficial effects of herbal extracts (HEs) on the regulation of inflammatory response in both in vitro and in vivo studies of AD. This review summarizes the anti-atopic effects of HEs and its associated underlying mechanisms, with a brief introduction of in vitro and in vivo experiment models of AD based on previous and recent studies. Thus, this review confirms the utility of HEs for AD therapy.

Keywords

Acknowledgement

This research was supported by grants from the KRIBB Research Initiative Program (grant no. KGM5522322) and Korea Drug Development Fund funded by Ministry of Science and ICT, Ministry of Trade, Industry, and Energy, and Ministry of Health and Welfare (grant no. HN21C0996) of the Republic of Korea.

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