The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Boyanghwano-tang for Diabetic Retinopathy: A Systematic Review and Meta-Analysis

당뇨병성 망막병증에 대한 보양환오탕(補陽還五湯)의 효과: 체계적 문헌 고찰 및 메타분석

  • Jeong-Hwa Oh (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University) ;
  • Hae-Na Kim (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University) ;
  • Hwa-Jung Yoon (Dept. of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University)
  • 오정화 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 김혜나 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 윤화정 (동의대학교 한의과대학 안이비인후피부과학 교실)
  • Received : 2023.10.07
  • Accepted : 2023.11.04
  • Published : 2023.11.25
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study is to assess the effect of using Boyanghwano-tang(BYHWT) for diabetic retinopathy. Methods : We searched randomized controlled trials(RCTs) that used BYHWT for diabetic retinopathy in 10 databases(RISS, KISS, ScienceON, KCI, OASIS, DBpia, CNKI, Wanfang Database, PubMed, Cochrane Library) on August 12, 2023. Outcome measurements included total effective rate(TER) and visual acuity as the primary outcome measurements, and the secondary outcome measurements included fasting blood glucose(FBG), 2hPG, HbA1c, ET-1, NO, etc. The indicator of stability included adverse reactions. A meta-analysis was conducted according to TER, visual acuity, FBG. Results : A total of 8 randomized control trials were selected. The treatment group which used BYHWT showed significant improvement effects in TER and visual acuity compared to the control group which used western medicine or chinese patent medicine alone. TER: (RR: 1.22, CI 1.14 to 1.31, P=<0.00001), visual acuity: (RR: 2.06, CI 1.40 to 3.03, P=0.0002). Secondary outcome measurements including FBG also showed improvement in the treatment group compared to the control group. FBG: (MD: -0.15, CI -0.43 to 0.31, P=0.28). Adverse reactions were only mentioned in one study, which showed that no adverse reactions occurred in both the treatment and control groups. Conclusions : This study suggests that BYHWT is effective for diabetic retinopathy. However these findings should be interpreted cautiously due to the insufficient number of studies and unknown or high risk of bias in the included trials.

Keywords

References

  1. Kim HS, Kim HM, Seong GJ, Yoo YS, Kwak SI, Kim SJ, et al. Ophthalmology. 10th ed. Seoul:Ilchokak. 2014:268-73,279-83,430-2. 
  2. Korea Disease Control and Prevention Agency. Health Statistics 2021. 2022[cited 2022 DEC 30]. Available from: https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_01.do. 
  3. Korea Disease Control and Prevention Agency. Health Statistics 2012. 2013[cited 2013 DEC 24]. Available from: https://knhanes.kdca.go.kr/knhanes/sub04/sub04_04_01.do. 
  4. Yoon JS, Baek SK, Lee YH. Risk Factor Analysis of Diabetic Retinopathy Diagnosed with Non-mydriatic Fundus Camera: KNHANES V. Journal of The Korean Ophthalmological Society. 2019;60(6):555-68.  https://doi.org/10.3341/jkos.2019.60.6.555
  5. The Society of Korean Medicine Ophthalomology, Otolaryngology & Dermatology. Text of Traditional Korean Ophthalomology. 1st ed. Paju:Globooks. 2019:171,172. 
  6. Hanuigwadaehak Bangjehak Pyeonchanwiwonhoe. Bangjehak. Seoul:Youngrimsa. 1999:414-6. 
  7. Park JH, Han YH, Jun CY, Kim DU, Park SG, Lee CJH, et al. The Effects of Boyanghwanotang on the Thrombosis Related Factors. The Journal of Korean Oriental Internal Medicine. 2000;21(5):829-37. 
  8. Jung WS, Ko CN, Kim YS, Bae HS, Lee KS. Experimental study on the effects of Boyanghwanoh-tang(補陽還五湯) on blood pressure and hyperlipidemia. The Journal of Korean Oriental Internal Medicine. 1997;18(2):246-67. 
  9. Han CH, Pak YK. The Effect of Modified Boyanghwano-tang on the Brain Infarction Through the Anti-apoptosis of Neuronal Cells in Ischemic Rats. Journal of Korean acupuncture & moxibustion medicine society. 2010;27(4):29-38. 
  10. Zhao J, Mo C, Meng LF, Liang CQ, Cao X, Shi W. Efficacy and safety of Buyang Huanwu Decoction for early-stage diabetic nephropathy: a Meta-analysis. Zhongguo Zhong Yao Za Zhi. 2019;44(8):1660-7. 
  11. Zhang M, Hao X, Tang Y, Chen Y, He P, Zhao L, et al. Efficacy and safety of Buyang Huanwu decoction for diabetic peripheral neuropathy: a systematic review and Metaanalysis. The Journal of Traditional Chinese Medicine. 2023;43(5):841-50. 
  12. Yao J, Weng H, Chen S. Clinical experience of Buyang Huanwu decoction combined with mosapride in the treatment of diabetic gastroparesis. Strait Pharmacy. 2020;32(11):167,168. 
  13. Jung JH, Kwon K, Seo HS. Clinical Study on one Patient with Vitreous Hemorrhage Caused by Diabetic Retinopathy. J Korean Med Ophthalmol Otolaryngol Dermatol. 2004;17(2):112-9. 
  14. Lee DJ, Lee ME, Kwon K, Seo HS. A Case Report of Diabetic Retinopathy Vitreous Hemorrhage. J Korean Med Ophthalmol Otolaryngol Dermatol. 2018;31(2):152-9. 
  15. Zhong W, Du H. Curative Effect Analysis of Buyang Huanwu Decoction on Non-proliferative Diabetic Retinopathy. Smart Healthcare. 2019;30(5):173,174. 
  16. Ai H. 40 cases of diabetic retinopathy treated with modified Buyang Huanwu Decoction and Liujunzi Decoction. Global Traditional Chinese Medicine. 2018;11(10):1614-7. 
  17. Tang H, Song Y, Zhang Z, Wang Y. A review of the efficacy of Buyang Huanwu Decoction in the treatment of non-proliferative diabetic retinopathy. China Practical Medicine. 2013;8(8):172,173. 
  18. Tang A, Li S, Hao X, Zhou W, Zhong J, Deng Y. Effect of modified Buyanghuanwu decoction on plasma ET - 1 and NO in nonproliferative diabetic retinopathy. Proceedings of the Fourteenth National Conference of Chinese Medicine on Diabete. 2011;28(12):2328,2329. 
  19. Tang A, Li L, Zhou W. Influence of Buyanghuanwu decoction on hemorrheology in patients with nonproliferative diabetic retinopathy. Hebei Journal of Traditional Chinese Medicine. 2007;29(10):929-31. 
  20. Lu Y. Clinical effects of combined laser and oriental medicine in the treatment of type 2 diabetic retinopathy. Inner Mongolia Journal of Traditional Chinese Medicine. 2020;39(3):125,126. 
  21. Yang L. Clinical observation of Buyang Huanwu decoction combined with calcium dobesilate in treating diabetes retinopathy. CHINA'S NATUROPATHY. 2019;27(17):60,61. 
  22. Qu L, Yao X. Observations on the integrated efficacy of Oriental medicine and Western medicine in the treatment of nonproliferative diabetic retinopathy. HENAN TRADITIONAL CHINESE MEDICINE. 2009;29(10):1019,1020. 
  23. Zhang X, Liu W, Wu S, Jin J, Li W, Wang N. Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis. Science China Life Sciences. 2015;58(1):101-7.  https://doi.org/10.1007/s11427-014-4792-1
  24. Jian W, Yu S, Tang M, Duan H, Huang J. A combination of the main constituents of Fufang Xueshuantong Capsules shows protective effects against streptozotocin-induced retinal lesions in rats. Journal of Ethnopharmacology. 2016;182:50-6.  https://doi.org/10.1016/j.jep.2015.11.021
  25. Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Beket T, et al. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35(3):556-64.  https://doi.org/10.2337/dc11-1909
  26. Mansour SE, Browning DJ, Wong K, Flynn HW, Bhavsar AR. The Evolving Treatment of Di abetic Retinopathy. Clinical Ophthalmology. 2020;14:653-78.  https://doi.org/10.2147/OPTH.S236637
  27. Nuzzi R, Tridico F. Local and systemic compl ications after intravitreal administration of a nti-vascular endothelial growth factor agents in the treatment of different ocular diseases: a five-year retrospective study. Semin Ophth almol. 2015;30(2):129-35.  https://doi.org/10.3109/08820538.2013.835833
  28. Deschler EK, Sun JK, Silva PS. Side-effects and complications of laser treatment in diabetic retinal disease. Semin Ophthalmol. 2014;29(5):290-300.  https://doi.org/10.3109/08820538.2014.959198
  29. Korea Institute Of Oriental Medicine. MEDIC LASSICS. 2015[cited 2021 SEP 14]. Available from: https://mediclassics.kr/books/8/volume/14#content_1080 
  30. Kai Z, Michela P, Antonio P, Annamaria P. Biological active ingredients of traditional Chinese herb Astragalus membranaceus on treatment of diabetes: a systematic review. Mini-Reviews in Medicinal Chemistry. 2015;15(4):315-29.  https://doi.org/10.2174/1389557515666150227113431
  31. Jin Q, Hao XF, Xie LK, Xu J, Sun M, Yuan H, et al. A Network Pharmacology to Explore the Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Retinopathy. Evidence-Based Complementary and Alternative Medicine. 2020;2020:1-12. https://doi.org/10.1155/2020/8878569