한방안이비인후피부과학회지 (The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology)

  • 제36권4호
  • /
  • Pages.30-50
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  • 2023
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  • 1738-6640(pISSN)
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  • 2234-4020(eISSN)
대한한방안이비인후피부과학회 (The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology)
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네트워크 약리학을 이용한 소양증을 동반한 피부 염증에 대한 창출(蒼朮) 및 후박(厚朴)의 잠재적 치료기전 탐색

Analysis of Potential Active Ingredients and Treatment Mechanism of Atractylodes Lancea(Thunb.) D.C and Magnolia Officinalis Rehder et Wilson for Dermatitis Accompanied by Pruritus Using Network Pharmacology

  • 홍예은 (경희대학교 대학원 한의과대학 안이비인후피부과학교실) ;
  • 서광일 (경희대학교 한방병원 안이비인후피부과) ;
  • 김병현 (경희대학교 대학원 한의과대학 안이비인후피부과학교실) ;
  • 김규석 (경희대학교 대학원 한의과대학 안이비인후피부과학교실) ;
  • 남혜정 (경희대학교 대학원 한의과대학 안이비인후피부과학교실) ;
  • 김윤범 (경희대학교 대학원 한의과대학 안이비인후피부과학교실)
  • YeEun Hong (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Graduate School, Kyung Hee University ) ;
  • GwangYeel Seo (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Kyung Hee University Korean Medicine Hospital) ;
  • Byunghyun Kim (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Graduate School, Kyung Hee University ) ;
  • Kyuseok Kim (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Graduate School, Kyung Hee University ) ;
  • Haejeong Nam (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Graduate School, Kyung Hee University ) ;
  • YoonBum Kim (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Graduate School, Kyung Hee University )
  • 투고 : 2023.10.06
  • 심사 : 2023.11.03
  • 발행 : 2023.11.25
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초록

Objectives : To investigate the active compounds and therapeutic mechanisms of Atractylodes Lancea(Thunb.) D.C. and Magnolia Officinalis Rehder et Wilson in the treatment of dermatitis accompanied by pruritus, as well as their potential to complement or replace standard drugs. Methods : We conducted the network pharmacological analysis. We selected effective ingredients among the active compounds of research target herbs. Then we explore pathway/terms of the common target proteins among research target herbs, fexofenadine and disease. Results : We selected 9 active compounds are selected from Atractylodes lancea and identified 231 target proteins. Among them, 74 proteins are associated with inflammatory skin diseases that cause pruritus. These proteins are involved in various pathways including, 'Nitric-oxide synthase regulator activity', 'Hydroperoxy icosatetraenoate dehydratase activity, Aromatase activity', 'RNA-directed DNA polymerase activity', 'Arachidonic acid metabolism', 'Peptide hormone processing', 'Chemokine binding' and 'Sterol biosynthetic process'. Additionally, coregenes are involved in 'IL-17 signaling pathway'. Similarly, we selected 2 active compounds from Magnolia officinalis and identified 133 target proteins. Among them, 33 proteins are related to inflammatory skin diseases that cause pruritus. These proteins are primarily involved in 'Vascular associated smooth muscle cell proliferation' and 'Arachidonic acid metabolism'. There is no significant difference between the pathways in which coregenes are involved. Conclusions : It is expected that Atractylodes Lancea will be able to show direct or indirect anti-pruritus and anti-inflammatory effects on skin inflammation accompanied pruritus through suppressing inflammation and protecting skin barrier. Meanwhile, it is expected that Magnolia Officinalis will only be able to show indirect anti-inflammation effects. Therefore, Atractylodes Lancea and fexofenadine are believed to complement each other, whereas Magnolia Officialinalis is expected to provide supplementary support on skin disease.

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