The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Herbal Medicine for Premenstrual Syndrome: A Systematic Review and Meta-analysis

월경전증후군에 대한 한약 치료의 효과 : 체계적 문헌 고찰과 메타 분석

  • Ji-In Seo (College of Korean Medicine, Woosuk University) ;
  • Yun-Jae Lee (College of Korean Medicine, Woosuk University) ;
  • Seo-Lim Ko (College of Korean Medicine, Woosuk University) ;
  • Nu-Ree Kim (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Woosuk University) ;
  • Jeong-Hun Kim (Woosuk University Evidence-based Healthcare Research Collaborating Center) ;
  • Mi-Ju Son (R&D Planning Team, Korea Institute of Oriental Medicine) ;
  • Young-Eun Kim (KM Data Division, Korea Institute of Oriental Medicine) ;
  • An-Na Kim (KM Data Division, Korea Institute of Oriental Medicine) ;
  • Eun-Hee Lee (Dept. of Korean Obstetrics and Gynecology, College of Korean Medicine, Woosuk University)
  • 서지인 (우석대학교 한의과대학) ;
  • 이윤재 (우석대학교 한의과대학) ;
  • 고서림 (우석대학교 한의과대학) ;
  • 김누리 (우석대학교, 한의과대학 한방부인과학교실) ;
  • 김정훈 (우석대학교 근거중심보건의료연구협력센터) ;
  • 손미주 (한국한의학연구원 연구기획팀) ;
  • 김영은 (한국한의학연구원 한의약데이터부) ;
  • 김안나 (한국한의학연구원 한의약데이터부) ;
  • 이은희 (우석대학교, 한의과대학 한방부인과학교실)
  • Received : 2023.10.12
  • Accepted : 2023.11.24
  • Published : 2023.11.24
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Abstract

Objectives: This study reports the findings that support the efficacy of herbal medicine (HM) for premenstrual syndrome (PMS). Methods: We conducted meta-analysis of findings from randomized controlled trials (RCTs) for PMS treated with HM. The articles were published before July 2022, located using 9 databases (Pubmed, EMBASE, Cochrane Library, CINAHL, CNKI, CiNii, SCIENCE ON, KoreaMed, OASIS). Results: We observed 2,034 studies, of which 23 RCTs met our inclusion criteria. The risk of bias in the included studies was relatively unclear or high. Meta-analysis of 3 RCTs showed that HM group had a significantly higher total effective rate than the western medicine group (RR 1.20 [95% CI 1.06, 1.36, p=0.004]). Meta-analysis of 1 RCT showed that HM group had a significantly lower symptom score (MD -3.04 [95% CI -5.36, -0.72, p=0.01]), while there was no significant difference in daily record of severity of problems scale (MD -20.52 [95% CI -49.33, 8.29, p=0.16]). Conclusions: HM significantly improved PMS symptoms than general treatment and no serious adverse events were reported. However, the evidence on the effectiveness and safety of HM for PMS was not enough to provide reliable results due to the small number and low quality of included studies. We believe that rigorous RCTs will lead to more reliable evidence of the intervention.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술연구개발사업(HF22C0046) 지원을 받아 수행되었습니다.

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