The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Analysis of the current status of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance

건강보험 급여 한약제제 56종 처방의 계량적 문헌 근거 현황 분석

  • Chul Kim (KM Data Division, Korea Institute of Oriental Medicine) ;
  • Hyeun-kyoo Shin (KM Science Research Division, Korea Institute of Oriental Medicine)
  • 김철 (한국한의학연구원 한의약데이터부) ;
  • 신현규 (한국한의학연구원 한의과학연구부)
  • Received : 2023.07.24
  • Accepted : 2023.08.22
  • Published : 2023.09.01
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Abstract

Objectives: The purpose of this study is to analyze the current state of quantitative literature evidence for the prescription of 56 herbal medicines covered by health insurance that have been studied in Korea for the past 30 years, to evaluate the reliability of the evidence, and to find out the research direction of herbal medicine prescription in the future. Methods: 56 kinds of herbal medicine prescriptions were searched in domestic literature search databases OASIS, DBpia, and overseas PubMed, classified into chemistry, toxicity, cells, animals, clinical cases, and clinical trial studies, and built into an EBM pyramid structure. Results: When classified according to research contents, there were 61 cases (7.5%) of physicochemical analysis to identify constituent substances, 80 cases (9.8%) of toxicity evaluation, and 672 cases (82.7%) of efficacy evaluation. The efficacy evidence was classified according to the evidence-based medical pyramid structure: 196 cell trials (29.1%), 372 animal trials (55.4%), 89 case and case reporting series (13.3%), 7 comparative case studies (1.1%), and 8 randomized control clinical trials (1.2%). In the pyramid composition, the basis for the validity of 56 kinds of herbal medicines prescribed was 568 cases (84.5%) in cell and animal units, which could not be said to be highly reliable. There was no relationship between the ranking of quantitative literature evidence for herbal medicine prescriptions and the ranking of salary administration. Conclusions: In an era that continues to require scientific evidence for herbal medicine, traditional herbal medicine should secure the basis for safety validity even for the 10th most frequent prescription among 56 herbal medicine prescriptions for consumers. In particular, traditional herbal medicine should increase the quantitative and qualitative level of case reports on related herbal medicine prescriptions, focusing on each clinical society, and move toward comparative case studies and randomized clinical trial so that traditional herbal medicine is positioned as Evidence-based medicine.

Keywords

Acknowledgement

본 연구는 한국한의학연구원의 '한방의료기관 한약처방 안전성·유효성 구축 사업 (KSN1823310, KSN1823311)' 에서 연구비를 지원 받아 진행되었습니다.

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