대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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표준 치료를 받고 있는 제2형 당뇨병 환자에서 혈당강하제와 평위산 및 향사평위산 병용 투여가 혈당에 미치는 영향 및 안정성 연구

Assessment of Combined Administration of Hypoglycemic Agents and Herbal Extracts (Pyeongwi-san or HyangsaPyongwi-san) on Blood Glucose Levels in Type 2 Diabetes Mellitus: A Retrospective Study

  • 정우녕 (경희대학교 대학원 임상한의학과) ;
  • 오승현 (경희대학교 대학원 임상한의학과) ;
  • 송미령 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 노지원 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 안영민 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 안세영 (경희대학교 한의과대학 부속병원 신장내분비내과교실) ;
  • 이병철 (경희대학교 한의과대학 부속병원 신장내분비내과교실)
  • Woo-nyoung Jung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Seung-hyun Oh (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Mee-ryoung Song (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Ji-won Noh (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Young-min Ahn (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Se-young Ahn (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Byung-cheol Lee (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
  • 투고 : 2023.08.27
  • 심사 : 2023.10.06
  • 발행 : 2023.09.30
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초록

Abstract: This retrospective study delved into the effects and safety considerations associated with the concomitant usage of hypoglycemic agents and herbal extracts, specifically Pyeongwi-san (PWS) or HyangsaPyongwi-san (HSPWS) in the context of type 2 diabetes mellitus management. Methods: The investigation involved 38 inpatients with type 2 diabetes mellitus who received PWS or HSPWS treatment at Kyung Hee University Korean Medical Hospital from January 2012 to December 2022. By investigating clinical attributes and conducting laboratory assessments, this study aimed to discern the impact of these herbal extracts on blood glucose levels, encompassing fasting blood sugar (FBS) and mean 2-hour postprandial glucose (PP2) levels. Furthermore, the safety profile of the herbal extracts was assessed by comparing liver function indicators, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (GGT), alongside kidney function markers, such as blood urea nitrogen (BUN) and creatinine (Cr). Results: Following the administration of the herbal extracts, no statistically significant alterations in FBS and mean PP2 levels emerged compared to the baseline levels. Notably, the safety evaluation revealed no significant differences in liver and kidney function parameters following herbal extract administration. Conclusion: The results of this research indicate that using PWS or HSPWS alongside hypoglycemic medications could be a beneficial additional method for addressing digestive symptoms in individuals with type 2 diabetes mellitus. Notably, this combination seems to have no negative interactions with other drugs.

키워드

과제정보

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0022).

참고문헌

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