대한의생명과학회지 (Biomedical Science Letters)

  • 제29권3호
  • /
  • Pages.168-177
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  • 2023
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Immunoactivity-Enhancing Effect of Fermented Samultang Porridge in an Animal Model of Cyclophospahmide-Induced Immunodeficiency

  • Ji-Hye Oh (Department of Biomedical Laboratory Science, Daejeon University) ;
  • Seung-Hwa Baek (Department of Biomedical Laboratory Science, Daejeon University) ;
  • Hak-Joo Cho (Department of Herbology, Collge of Korean Medicine, Daejeon University) ;
  • Seock-Yeon Hwang (Department of Biomedical Laboratory Science, Daejeon University)
  • 투고 : 2023.09.11
  • 심사 : 2023.09.22
  • 발행 : 2023.09.30
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초록

Recently, as a health problem of the elderly in an aging society, the risk of nutritional imbalance and weakening of immunity due to deterioration of masticatory function has been mentioned. In order to solve this problem, this study was conducted to investigate the effect of cyclophosphamide (CPA)-induced immunosuppression in mice induced by fermented samultang (FST) porridge on the markers related to immune activity function. ICR Mouse was divided into 6 groups of 7 animals each. Experimental groups were set as normal control group, CPA-administration group, positive control group, and FST-administration experimental group (0.25%, 0.5%, 1.0%). In groups except for the normal control group, 100 µL of CPA dissolved in 0.9% NaCl at a concentration of 150 mg/kg was injected twice at the start of the experiment and after 3 days to induce immunosuppression. As a result of analyzing the cell proliferation capacity of splenocytes, all B and T cells decreased in the CPA-administered group and increased in a concentration-dependent manner in the FST-administered group. In addition, IgA measured to evaluate the effect of improving immunity showed high values in medium and high concentration FST (P<0.05). These results can be expected as an effective solution to improve the nutritional imbalance of the elderly.

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참고문헌

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