Journal of Periodontal and Implant Science

  • 제53권4호
  • /
  • Pages.283-294
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  • 2023
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
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Increased prevalence of periodontitis with hypouricemic status: findings from the Korean National Health and Nutrition Examination Survey, 2016-2018

  • Ji-Young Joo (Department of Periodontology, Dental Research Institute, Pusan National University Dental Hospital) ;
  • Hae Ryoun Park (Periodontal Disease Signaling Network Research Center, Dental and Life Science Institute, Pusan National University School of Dentistry) ;
  • Youngseuk Cho (Department of Statistics, Pusan National University College of Natural Sciences) ;
  • Yunhwan Noh (Department of Statistics, Pusan National University College of Natural Sciences) ;
  • Chang Hun Lee (Department of Pathology, Pusan National University School of Medicine) ;
  • Seung-Geun Lee (Department of Internal Medicine, Pusan National University School of Medicine and Pusan National University Hospital)
  • 투고 : 2022.04.21
  • 심사 : 2022.11.08
  • 발행 : 2023.08.31
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초록

Purpose: The aim of this study was to investigate the relationship between serum uric acid (SUA) levels and the risk of periodontitis in Korean adults using data from the Korean National Health and Nutrition Examination Survey (KNHANES). Methods: This cross-sectional study used data from the KNHANES 2016-2018 and analysed 12,735 Korean adults aged ≥19 years who underwent oral examinations. Hypouricemia was defined as SUA <3 mg/dL in men and <2 mg/dL in women, and hyperuricemia was defined as SUA ≥7 mg/dL in men and ≥6 mg/dL in women. Results: The weighted prevalence of hypouricemia and hyperuricemia was 0.6% and 12.9%, respectively. The overall weighted periodontitis rate was 30.5%. The frequency of periodontitis in subjects with hypouricemia, normouricemia, and hyperuricemia were 51.1%, 30.3%, and 30.6%, respectively. Study participants with hypouricemia were significantly older, had significantly fasting blood glucose levels, and had better kidney function than non-hypouricemic participants. In univariate logistic regression analyses, hypouricemia was associated with periodontitis, but hyperuricemia was not. The fully adjusted model revealed that the adjusted odds ratio of hypouricemia for periodontitis was 1.62 (95% confidence interval, 1.13-2.33), while the relationship between hyperuricemia and periodontitis in the multivariable logistic regression model was not significant. Conclusions: The results of this study suggest that hypouricemia is associated with an increased risk of periodontitis.

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과제정보

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. NRF-2018R1A5A2023879).

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