Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Twelve-oxoeicosatetraenoic acid-induced fetal membrane release improves postpartum ovarian function, milk production, and blood plasma biochemical parameters in cows

  • Hachiro Kamada (Institute of livestock and Grassland Science, NARO) ;
  • Yoshitaka Matsui (Hokkaido Research Organization, Agricultural Research Department, Dairy Research Center)
  • Received : 2022.11.22
  • Accepted : 2023.01.30
  • Published : 2023.09.01
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Abstract

Objective: We aimed to determine the effects of 12-oxoeicosatetraenoic acid (12-KETE)-induced placenta release on the performance of mother cows (milk yield, ovarian function, and blood plasma biochemical properties). Methods: Experimental treatments were as follows: i) natural delivery including natural placental release (control cows); ii) induced calf delivery with placental retention (RP cows); and iii) induced calf delivery and 12-KETE-induced placental release (KE cows). Delivery in pregnant KE cows was induced with dexamethasone and prostaglandin. These cows were injected with 12-KETE after calf discharge, resulting in the release of the fetal placenta. RP cows were not treated with 12-KETE after inducing delivery, resulting in placental retention. Results: The milk yield in RP cows during the first 50 days after delivery was significantly lower than that in control cows (p<0.05), whereas KE cows exhibited a similar milk yield to that of control cows. The postpartum plasma progesterone levels of control cows increased 14 days after delivery on average; however, its increase was delayed by 10 days in RP cows. Meanwhile, the 12-KETE treatment (KE cows) brought the timing of progesterone increase forward to the normal level (control cows). Among the 20 biochemical parameters examined, the total cholesterol levels in blood plasma 14 days after delivery were lower in RP cows than that in the other two treatment groups (control cows and KE cows) (p<0.05). In addition, the plasma level of haptoglobin tended to be low in cows that discharged their placentas shortly after delivery. Conclusion: These findings indicate that 12-KETE treatment can alleviate the disorder caused by placental retention.

Keywords

Acknowledgement

We would like to thank the staff of the ruminant and field management section of our institute for their assistance with animal handling and care. We also thank Editage for English language editing.

References

  1. Hossein-Zadeh NG. Effect of dystocia on subsequent reproductive performance and functional longevity in Holstein cows. Anim Physiol Anim Nutr 2016;100:860-7. https://doi.org/10.1111/jpn.12460 
  2. Gundelach Y, Essmeyer K, Teltscher MK, Hoedemaker M. Risk factors for perinatal mortality in dairy cattle: Cow and foetal factors, calving process. Theriogenology 2009;71:901-9. https://doi.org/10.1016/j.theriogenology.2008.10.011 
  3. Gaafer HMA, Shamiah SM, Abu El-Hamd MA, Shitta AA, Tag El-Din MA. Dystocia in Friesian cows and its effects on postpartum reproductive performance and milk production. Trop Anim Health Prod 2011;43:229-34. https://doi.org/10.1007/s11250-010-9682-3 
  4. Sasaki Y, Uematsu M, Kitahara G. Effects of stillbirth and dystocia on subsequent reproductive performance in Japanese Black cattle. Vet J 2014;200:462-3. https://doi.org/10.1016/j.tvjl.2014.03.004 
  5. Villettaz Robichaud M, de Passille AM, Pearl DL, et al. Calving management practices on Canadian dairy farms: Prevalence of practices. J Dairy Sci 2016;99:2391-404. https://doi.org/10.3168/jds.2015-9641
  6. Jeffrey SS. Relationship among climatological variables and hourly distribution of calvings in Holsteins fed during the late afternoon. J Dairy Sci 1989;72:2712-7. https://doi.org/10.3168/jds.S0022-0302(89)79414-5 
  7. Lowman BG, Hankey MS, Scott NA, Deas DW, Hunter EA. Influence of time of feeding on time of parturition in beef cows. Vet Rec1981;109:557-9. 
  8. Yarney TA, Parker RJ, Palmer WM, Rahnefeld GW. Hourly distribution of time of parturition in beef cows. Can J Anim Sci 1982;62:597-605. https://doi.org/10.4141/cjas82-069 
  9. Kamada H, Matsui Y. Possibility of the prediction of parturition from the prepartum concentrations of steroid hormones in blood plasma of cows. Nihon Chikusan Gakkaiho 2017;88:431-7. https://doi.org/10.2508/chikusan.88.431 
  10. Savc M, Kenny DA, Beltman ME. The effect of parturition induction treatment on interval to calving, calving ease, postpartum uterine health, and resumption of ovarian cyclicity in beef heifers. Theriogenology 2016;85:1415-20. https://doi.org/10.1016/j.theriogenology.2015.12.026 
  11. Hartmann D, Honnens A, Piechotta M, et al. Effects of a protracted induction of parturition on the incidence of retained placenta and assessment of uterine artery blood flow as a measure of placental maturation in cattle. Theriogenology 2013;80:176-84. https://doi.org/10.1016/j.theriogenology.2013.02.001 
  12. Morton JM, Butler KL. The effects of induced parturition on the incidence of clinical disease and mortality in dairy cows from commercial herds in south-western Victoria. Aust Vet J 1995;72:1-4. https://doi.org/10.1111/j.1751-0813.1995.tb03465.x 
  13. MacDonald LE. Pregnancy and parturition. In: MacDonald LE, Pineda MH, editors. Veterinary endocrinology and reproduction. London, UK: Lea & Febigar; 1989. pp. 503-25. 
  14. Kamada H, Matsui Y, Sakurai Y, et al. Twelve oxo-eicosatetraenoic acid induces fetal membrane release after delivery in cows. Placenta 2012;33:106-13. https://doi.org/10.1016/j.placenta.2011.11.001 
  15. Kamada H. 12-oxoeicosatetraenoic acid, a candidate signal for placenta separation, activates matrix metalloproteinase and induces apoptosis in bovine trophoblast cells. Anim Biosci 2023;36:429-40. https://doi.org/10.5713/ab.22.0097 
  16. National Agriculture and Food Research Organization. Japan feeding standard for dairy cattle. Tokyo, Japan: Japan Livestock Industry Association; 2006. 
  17. Huzzey JM, Duffield TF, LeBlanc SJ, Veira DM, Weary DM, von Keyserlingk MAG. Short communication: Haptoglobin as an early indicator of metritis. J Dairy Sci 2009;92:621-5. https://doi.org/10.3168/jds.2008-1526 
  18. Maj JG, Kankofer M. Activity of 72-kDa and 92-kDa matrix metalloproteinases in placental tissues of cows with and without retained fetal membranes. Placenta 1997;18:683-7. https://doi.org/10.1016/S0143-4004(97)90010-2 
  19. Eiler H, Hopkins FM. Successful treatment of retained placenta with umbilical cord injections of collagenase in cows. J Am Vet Med Assoc 1993;203:436-43.  https://doi.org/10.2460/javma.1993.203.03.436
  20. Benedictus L, Koets AP, Kuijpers FH, Joosten I, van Eldik P, Heuven HCM. Heritable and non-heritable genetic effects on retained placenta in Meuse-Rhine-Yssel cattle. Anim Reprod Sci 2013;137:1-7. https://doi.org/10.1016/j.anireprosci.2012.12.006 
  21. Drillich M, Klever N, Heuwieser W. Comparison of two management strategies for retained fetal membranes on small dairy farms in Germany. J Dairy Sci 2007;90:4275-81. https://doi.org/10.3168/jds.2007-0131 
  22. Shaver RD. Nutritional risk factors in the etiology of left displaced abomasum in dairy cows: a review. J Dairy Sci 1997;80:2449-53. https://doi.org/10.3168/jds.S0022-0302(97)76197-6 
  23. Peters AR, Laven RA. Treatment of bovine retained placenta and its effects. Vet Rec 1996;139:535-9. https://doi.org/10.1136/vr.139.22.535 
  24. Buso RR, Campos CC, Santos TR, Saut JPE, Santos RM. Retained placenta and subclinical endometritis: prevalence and relation with reproduction performance of crossbred dairy cows. Pesq Vet Bras 2018;38:1-5. https://doi.org/10.1590/1678-5150-PVB-4707 
  25. Holt LC, Whittier WD, Gwazdauskas FC, Vinson WE. Early postpartum reproductive profiles in Holstein cows with retained placenta and uterine discharges. J Dairy Sci 1989;72:533-9.  https://doi.org/10.3168/jds.S0022-0302(89)79137-2
  26. Darwash AO, Lamming GE, Wooliams JA. The phenotypic association between the interval to post-partum ovulation and traditional measures of fertility in dairy cattle. Anim Sci 1997;65:9-16. https://doi.org/10.1017/S1357729800016234 
  27. Skinner JG, Brown RA, Roberts L. Bovine haptoglobin response in clinically defined field conditions. Vet Rec 1991;128:147-9.  https://doi.org/10.1136/vr.128.7.147
  28. Pohl A, Burfeind O, Heuwieser W. The associations between postpartum serum haptoglobin concentration and metabolic status, calving difficulties, retained fetal membranes, and metritis. J Dairy Sci 2015;98:4544-51. https://doi.org/10.3168/jds.2014-9181 
  29. Barragan AA, Pineiro JM, Schuenemann GM, et al. Assessment of daily activity patterns and biomarkers of pain, inflammation, and stress in lactating dairy cows diagnosed with clinical metritis. J Dairy Sci 2018;101:8248-58. https://doi.org/10.3168/jds.2018-14510 
  30. Trevisi E, Ferrari AR, Bertoni G. Productive and metabolic consequences induced by the retained placenta in dairy cows. Vet Res Commun 2008;32:363-6. https://doi.org/10.1007/s11259-008-9149-4 
  31. Johanson JM, Berge PJ, Tsuruta S, Misztal I. A Bayesian threshold-linear model evaluation of perinatal mortality, dystocia, birth weight, and gestation length in a Holstein herd. J Dairy Sci 2011;94:450-60. https://doi.org/10.3168/jds.2009-2992 
  32. Raboisson D, Delor F, Cahuzac E, Gendre C, Sans P, Allaire G. Perinatal, neonatal, and rearing period mortality of dairy calves and replacement heifers in France. J Dairy Sci 2013;96:2913-24. https://doi.org/10.3168/jds.2012-6010