Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
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The Therapeutic Effect of Medical Patches Including Isoegomaketone on the Collagen Antibody-induced Arthritis in Mice

관절염 유발 동물 모델에서 이소에고마케톤 함유 패치의 관절염 치료 효과

  • ChangHyun Jin (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Ye-Ram Kim (Department of Pathology and Immunology, Washington University School of Medicine) ;
  • Ah-Reum Han (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 진창현 (한국원자력연구원 첨단방사선연구소) ;
  • 김예람 (워싱턴대학교 의과대학 병리면역학과) ;
  • 한아름 (한국원자력연구원 첨단방사선연구소)
  • Received : 2023.10.11
  • Accepted : 2023.10.25
  • Published : 2023.12.31
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Abstract

This study identified effects of Isoegomaketone for applicable patch on the arthritis in mice. Isoegomaketone (IK) was isolated from Perilla frutescens, which is annual herbal traditional medicinal, aromatic, functional food. IK has various physiological effects such as anti-inflammation, anti-oxidant, and anti-cancer. In the previous study, oral administration of IK to a mouse model of collagen antibody-induced arthritis(CAIA), which is similar to human rheumatoid arthritis(RA), alleviated symptoms. In this study, we attached a patch containing IK to mouse skin to demonstrate whether it had the same efficacy as oral administration in CAIA mouse. As a result of measuring the arthritis score, paw volume, and paw thickness, it was confirmed that arthritis symptoms were alleviated in the group to which the patch containing IK was attached. These results show that IK is effective in alleviating arthritis not only through oral administration but also through patches applied to skin, and that it has potential as a material for future patch development.

Keywords

Acknowledgement

본 연구는 과학기술정보통신부의 재원으로 한국원자력연구원의 주요사업(523310-23)에 의해 수행되었으며, 그 지원에 감사드립니다

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