Biomolecules & Therapeutics

  • 제31권4호
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  • Pages.395-401
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  • 2023
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases

  • Annamneedi Venkata Prakash (Department of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Il-Ho Park (Department of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Jun Woo Park (Department of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Jae Pil Bae (Department of Pharmacy and Institute of Chronic Disease, Sahmyook University) ;
  • Geum Seon Lee (Department of Counseling and Psychology, Sahmyook University) ;
  • Tae Jin Kang (Department of Pharmacy and Institute of Chronic Disease, Sahmyook University)
  • 투고 : 2023.05.22
  • 심사 : 2023.05.30
  • 발행 : 2023.07.01
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초록

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

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과제정보

This paper was supported by the Academic Research Fund of Dr. Myung Ki (MIKE) Hong in 2021.

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