Biomolecules & Therapeutics

  • 제31권4호
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  • Pages.370-387
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  • 2023
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Antigen Delivery Systems: Past, Present, and Future

  • Hyun-Jeong Ko (Laboratory of Microbiology and Immunology, Department of Pharmacy, Kangwon National University) ;
  • Yeon-Jeong Kim (Laboratory of Microbiology and Immunology, College of Pharmacy, Inje University)
  • 투고 : 2023.01.09
  • 심사 : 2023.03.22
  • 발행 : 2023.07.01
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초록

The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants, and manufacturing processes is essential. Ag delivery systems are required not only to deliver a sufficient amount of Ag for vaccination, but also to enhance immune response. In addition, Ag types and their delivery systems determine the manufacturing processes of the vaccine product. Here, we analyze the characteristics of various Ag delivery systems: plasmids, viral vectors, bacterial vectors, nanoparticles, self-assembled particles, natural and artificial cells, and extracellular vesicles. This review provides insight into the current vaccine landscape and highlights promising avenues of research for the development and improvement of Ag delivery systems.

키워드

과제정보

This research was supported by a grant (21172MFDS722) from the Ministry of Food and Drug Safety in 2021.

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