Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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Association Between Persistent Treatment of Alzheimer's Dementia and Osteoporosis Using a Common Data Model

  • Seonhwa Hwang (Kangwon National University School of Medicine) ;
  • Yong Gwon Soung (Department of Neurology, Kangwon National University Hospital) ;
  • Seong Uk Kang (Department of Convergence Security, Kangwon National University) ;
  • Donghan Yu (Big Data Department, Health Insurance Review & Assessment Service) ;
  • Haeran Baek (Big Data Department, Health Insurance Review & Assessment Service) ;
  • Jae-Won Jang (Kangwon National University School of Medicine)
  • Received : 2023.06.29
  • Accepted : 2023.10.03
  • Published : 2023.10.31
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Abstract

Background and Purpose: As it becomes an aging society, interest in senile diseases is increasing. Alzheimer's dementia (AD) and osteoporosis are representative senile diseases. Various studies have reported that AD and osteoporosis share many risk factors that affect each other's incidence. This aimed to determine if active medication treatment of AD could affect the development of osteoporosis. Methods: The Health Insurance Review and Assessment Service provided data consisting of diagnosis, demographics, prescription drug, procedures, medical materials, and healthcare resources. In this study, data of all AD patients in South Korea who were registered under the national health insurance system were obtained. The cohort underwent conversion to an Observational Medical Outcomes Partnership-Common Data Model version 5 format. Results: This study included 11,355 individuals in the good persistent group and an equal number of 11,355 individuals in the poor persistent group from the National Health Claims database for AD drug treatment. In primary analysis, the risk of osteoporosis was significantly higher in the poor persistence group than in the good persistence group (hazard ratio, 1.20 [95% confidence interval, 1.09-1.32]; p<0.001). Conclusions: We found that the good persistence group treated with anti-dementia drugs for AD was associated with a significant lower risk of osteoporosis in this nationwide study. Further studies are needed to clarify the pathophysiological link in patients with two chronic diseases.

Keywords

Acknowledgement

We would like to thank the Health Insurance Review and Assessment Service for assistance in providing and analyzing data.

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