Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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Diagnostic Tools for Alzheimer's Disease: A Narrative Review Based on Our Own Research Experience

  • So-Hee Park (Department of Neurology, Bobath Memorial Hospital) ;
  • Kyoung Ja Kwon (Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine) ;
  • Min Young Kim (Department of Neurology, Konkuk University School of Medicine) ;
  • Jae-Hun Kim (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Won-Jin Moon (Department of Radiology, Konkuk University School of Medicine) ;
  • Hui Jin Ryu (Department of Neurology, Konkuk University School of Medicine) ;
  • Jae Won Jang (Department of Neurology, Kangwon National University Hospital, Kangwon National University) ;
  • Yeonsil Moon (Department of Neurology, Konkuk University School of Medicine) ;
  • K-ARPI (K-ARPI)
  • Received : 2023.01.31
  • Accepted : 2023.02.07
  • Published : 2023.01.31
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Abstract

Alzheimer's disease (AD), one of the most representative neurodegenerative diseases, has diverse neurobiological and pathophysiological mechanisms. Treatment strategies targeting a single mechanism have repeated faced failures because the mechanism of neuronal cell death is very complex that is not fully understood yet. Since complex mechanisms exist to explain AD, a variety of diagnostic biomarkers for diagnosing AD are required. Moreover, standardized evaluations for comprehensive diagnosis using neuropsychological, imaging, and laboratory tools are needed. In this review, we summarize the latest clinical, neuropsychological, imaging, and laboratory evaluations to diagnose patients with AD based on our own experience in conducting a prospective study.

Keywords

Acknowledgement

The Korean AD Research Platform Initiative based on Immune-inflammatory biomarkers (K-ARPI) Investigators are as follows: Seung Hyun Kim and Hee-Jin Kim (Hanyang University Hospital), Yeonsil Moon (Konkuk University Hospital), Jae Sung Bae and Hee Kyung Jin (Kyungpook National University), Beoung-Chae Kim (Chonnam National University Medical School), Ho Jin Choi (Hanyang University College of Medicine), Chan-Nyoung Lee (Korea University Hospital), Youngsoon Yang (Seoul Veterans Hospital), Yunjeong Hong (Uijeongbu St. Mary's Hospital), Jae-Won Jang (Kangwon National University Hospital), So-Hee Park (Bobath Memorial Hospital), and Kyoung Ja Kwon (Konkuk University School of Medicine).

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