Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Advanced Bioremediation Strategies for Organophosphorus Compounds

  • Anish Kumar Sharma (Department of Biotechnology, School of Sciences, P.P. Savani University) ;
  • Jyotsana Pandit (Department of Environmental Science, School of Sciences, P.P. Savani University)
  • Received : 2023.09.04
  • Accepted : 2023.11.03
  • Published : 2023.12.28
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Abstract

Organophosphorus (OP) pesticides, particularly malathion, parathion, diazinon, and chlorpyrifos, are widely used in both agricultural and residential contexts. This refractory quality is shared by certain organ phosphorus insecticides, and it may have unintended consequences for certain non-target soil species. Bioremediation cleans organic and inorganic contaminants using microbes and plants. Organophosphate-hydrolyzing enzymes can transform pesticide residues into non-hazardous byproducts and are increasingly being considered viable solutions to the problem of decontamination. When coupled with system analysis, the multi-omics technique produces important data for functional validation and genetic manipulation, both of which may be used to boost the efficiency of bioremediation systems. RNA-guided nucleases and RNA-guided base editors include zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR), which are used to alter genes and edit genomes. The review sheds light on key knowledge gaps and suggests approaches to pesticide cleanup using a variety of microbe-assisted methods. Researches, ecologists, and decision-makers can all benefit from having a better understanding of the usefulness and application of systems biology and gene editing in bioremediation evaluations.

Keywords

Acknowledgement

We are grateful to everyone who helped us finish this work. We also thank Dr. Parag Sanghani, Provost PP Savani University, for his encouragement, assistance, and generous resources, which helped us finish our research. Dr. Jyotsana Pandit's ideas and persistent effort in reviewing data and writing the report are also appreciated.

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