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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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The role of diuretic hormones (DHs) and their receptors in Drosophila

  • Gahbien Lee (Department of Life Sciences, College of Natural Sciences, Ewha Womans University) ;
  • Heejin Jang (Department of Life Sciences, College of Natural Sciences, Ewha Womans University) ;
  • Yangkyun Oh (Department of Life Sciences, College of Natural Sciences, Ewha Womans University)
  • Received : 2023.02.03
  • Accepted : 2023.03.28
  • Published : 2023.04.30
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Abstract

Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory inputs and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their receptors have multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrient-sensing, and CO2-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuroendocrine systems.

Keywords

Acknowledgement

This work was supported by the Ewha Womans University Research Grant of 2022 (1-2022-0352-001-1), the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. RS-2023-00212599) to Y.O.

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