Fisheries and Aquatic Sciences

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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α-amylase and α-glucosidase inhibition effects of Korean edible brown, green, and red seaweed extracts

  • Ju-Won Ryu (Department of Food Science and Technology, Dong-Eui University) ;
  • Myeong Seok Lee (National Marine Biodiversity Institute of Korea) ;
  • Mi-Jin Yim (National Marine Biodiversity Institute of Korea) ;
  • Jeong Min, Lee (National Marine Biodiversity Institute of Korea) ;
  • Dae-Sung Lee (National Marine Biodiversity Institute of Korea) ;
  • Young-Mog Kim (Department of Food Science and Technology, Pukyoung National University) ;
  • Sung-Hwan Eom (Department of Food Science and Technology, Dong-Eui University)
  • Received : 2022.12.07
  • Accepted : 2022.12.20
  • Published : 2023.03.31
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Abstract

The control of intestinal α-amylase and α-glucosidase is an effective therapeutic strategy for prevention of post-prandial hyperglycemia associated with diabetes mellitus. The objective of this study was to evaluate the anti-diabetes activities of Korean edible seaweed against α-amylase and α-glucosidase, two carbolytic enzymes involved in serum glucose regulation. Of the 41 species initially screened, Cladophora wrightiana var. minor, Eisenia bicyclis, Ecklonia cava, Ishige foliacea, and Ishige okamurae exhibited the strongest inhibitory activities from brown seaweeds. Asparagopsis taxiformis showed the strongest inhibitory effects from red seaweeds. The results of this study suggest that the crude brown seaweed extracts (C. wrightiana var. minor, E. bicyclis, E. cava, I. foliacea, and I. okamurae) and crude red seaweed extracts (A. taxiformis) may have beneficial effects suppressing the rise in postprandial hyperglycemia through the inhibition of α-amylase and α-glucosidase.

Keywords

Acknowledgement

This work was supported by National Marine Biodiversity Institute of Korea Research Program 2022M00500.

References

  1. Ahn CB, Jeon YJ, Kang DS, Shin TS, Jung BM. Free radical scavenging activity of enzymatic extracts from a brown seaweed Scytosiphon lomentaria by electron spin resonance spectrometry. Food Res Int. 2004;37:253-8. https://doi.org/10.1016/j.foodres.2003.12.002
  2. Ahmad F, Sulaiman MR, Saimon W, Yee CF, Matanjun P. Proximate compositions and total phenolic contents of selected edible seaweed from semporna, Sabah, Malaysia. Borneo Sci. 2012;31:85-96.
  3. Athukorala Y, Lee KW, Kim SK, Jeon YJ. Anticoagulant activity of marine green and brown algae collected from Jeju island in Korea. Bioresour Technol. 2007;98:1711-6. https://doi.org/10.1016/j.biortech.2006.07.034
  4. Blat Y. Non-competitive inhibition by active site binders. Chem Biol Drug Des. 2010;75:535-40. https://doi.org/10.1111/j.1747-0285.2010.00972.x
  5. Eom SH, Lee SH, Yoon NY, Jung WK, Jeon YJ, Kim SK, et al. α-Glucosidase-and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis. J Sci Food Agric. 2012;92:2084-90. https://doi.org/10.1002/jsfa.5585
  6. Fan W. Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol Metab. 2017;6:8-16. https://doi.org/10.1097/XCE.0000000000000116
  7. Fujisawa T, Ikegami H, Inoue K, Kawabata Y, Ogihara T. Effect of two α-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms. Metabolism. 2005;54:387-90. https://doi.org/10.1016/j.metabol.2004.10.004
  8. Gomez-Guzman M, Rodriguez-Nogales A, Algieri F, Galvez J. Potential role of seaweed polyphenols in cardiovascular-associated disorders. Mar Drugs. 2018;16:250.
  9. Gong L, Feng D, Wang T, Ren Y, Liu Y, Wang J. Inhibitors of α-amylase and α-glucosidase: potential linkage for whole cereal foods on prevention of hyperglycemia. Food Sci Nutr. 2020;8:6320-37. https://doi.org/10.1002/fsn3.1987
  10. Jeong SY, Qian ZJ, Jin YJ, Kim GO, Yun PY, Cho TO. Investigation of α-glucosidase inhibitory activity of ethanolic extracts from 19 species of marine macroalgae in Korea. Nat Prod Sci. 2012;18:130-6.
  11. Kim DH, Jung JY, Kim KBWR, Lee CJ, Kwak JH, Kim MJ, et al. Effects of heat and pH treatments on α-amylase inhibitory activity of Ecklonia cava ethanol extract. Korean J Fish Aquat Sci. 2011;44:791-5. https://doi.org/10.5657/KFAS.2011.0791
  12. Kim H. Utility technical development of algae origin ability anti-diabetes food that take advantage of small molecule processing technology. Seoul: Ministry of Agriculture, Food and Rural Affairs; 2010. Report No.: 1545001252.
  13. Kim JH, Kang HM, Lee SH, Lee JY, Park LY. Antioxidant and α-glucosidase inhibition activity of seaweed extracts. Korean J Food Preserv. 2015;22:290-6. https://doi.org/10.11002/kjfp.2015.22.2.290
  14. Kim TH, Jung WK. R&D trends of brown algae as potential candidates in biomedical application. J Mar Biosci Biotechnol. 2019;11:1-13.
  15. Kim YM, Wang MH, Rhee HI. A novel α-glucosidase inhibitor from pine bark. Carbohydr Res. 2004;339:715-7. https://doi.org/10.1016/j.carres.2003.11.005
  16. Lee MS, Yim MJ, Lee JM, Lee DS, Kim MY, Eom SH. In vitro antimicrobial activities of edible seaweeds extracts against cutibacterium acnes. Korean J Fish Aquat Sci. 2021;54:111-7.
  17. Lee SJ. Lipase and α-amylase inhibitory activity of Sargassum thunbergii extracts [M.S. thesis]. Busan: Pukyong National University; 2010.
  18. Lopes G, Andrade PB, Valentao P. Phlorotannins: towards new pharmacological interventions for diabetes mellitus type 2. Molecules. 2017;22:56.
  19. Lordan S, Smyth TJ, Soler-Vila A, Stanton C, Paul Ross R. The α-amylase and α-glucosidase inhibitory effects of Irish seaweed extracts. Food Chem. 2013;141:2170-6. https://doi.org/10.1016/j.foodchem.2013.04.123
  20. Mikami K, Hosokawa M. Biosynthetic pathway and health benefits of fucoxanthin, an algae-specific xanthophyll in brown seaweeds. Int J Mol Sci. 2013;14:13763-81. https://doi.org/10.3390/ijms140713763
  21. Pak WM, Kim KBWR, Kim MJ, Cho JY, Ahn DH. Inhibitory effect of hexane fraction from myagropsis myagroides on pancreatic α-amylase in vitro. J Microbiol Biotechnol. 2015;25:328-33. https://doi.org/10.4014/jmb.1409.09012
  22. Park MH, Han JS. Hypoglycemic effect of Padina arborescens extract in streptozotocin-induced diabetic mice. Prev Nutr Food Sci. 2012;17:239-44. https://doi.org/10.3746/pnf.2012.17.4.239
  23. Park SR, Kim JH, Jang HD, Yang SY, Kim YH. Inhibitory activity of minor phlorotannins from Ecklonia cava on α-glucosidase. Food Chem. 2018;128-34.
  24. Rindi F, Soler-Vila A, Guiry MD. Taxonomy of marine macroalgae used as sources of bioactive compounds. In: Hayes M, editor. Marine bioactive compounds. New York, NY: Springer; 2012. p. 1-53.
  25. Ryu BM, Jiang Y, Kim HS, Hyun JM, Lim SB, Li Y, et al. Ishophloroglucin A, a novel phlorotannin for standardizing the anti-α-glucosidase activity of Ishige okamurae. Mar Drugs. 2018;16:436.
  26. Simmons KM, Michels AW. Type 1 diabetes: a predictable disease. World J Diabetes. 2015;6:380-90. https://doi.org/10.4239/wjd.v6.i3.380
  27. Tabish SA. Is diabetes becoming the biggest epidemic of the twenty-first century? Int J Health Sci. 2007;1:V-VIII.
  28. Wang L, Park YJ, Jeon YJ, Ryu BM. Bioactivities of the edible brown seaweed, Undaria pinnatifida: a review. Aquaculture. 2018;495:873-80. https://doi.org/10.1016/j.aquaculture.2018.06.079
  29. Widyaswari SG, Metusalach, Kasmiati, Amir N. A review: bioactive compounds of macroalgae and their application as functional beverages. IOP Conf Ser Earth Environ Sci. 2021;679:012002.
  30. Yang J, Liu C, Cai H, Dongyu G, Zhenni J, Guo X, et al. Identification and theoretical explanation of chemical composition against α-amylase in the n-hexane extract from Sargassum fusiforme. Algal Res. 2019;43:101642.
  31. Zaharudin N, Staerk D, Dragsted LO. Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. Food Chem. 2019;270:481-6. https://doi.org/10.1016/j.foodchem.2018.07.142