Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Differences in Neurotransmitters Level as Biomarker on Sleep Effects in Dementia Patients with Insomnia after Essential Oils Treatment

  • Kyung-Bok Lee (Research Institute of Pharmaceutical Science and College of Pharmacy, Sookmyung Women's University) ;
  • Sana Latif (Research Institute of Pharmaceutical Science and College of Pharmacy, Sookmyung Women's University) ;
  • Young-Sook Kang (Research Institute of Pharmaceutical Science and College of Pharmacy, Sookmyung Women's University)
  • Received : 2023.01.17
  • Accepted : 2023.02.12
  • Published : 2023.05.01
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Abstract

This study aimed to examine the effects of several essential oils on insomnia in dementia patients following transdermal treatment (aromatherapy). The mean change rates (%) of sleep biomarkers were compared between the single essential and jojoba (vehicle) oil massage groups in this study. The lavender (L) essential oil massage group demonstrated a significant decrease in the mean change rate (%) of 24-h urinary free cortisol, whereas the valerian (V) essential oil massage group demonstrated a significant increase in the mean change rate (%) of serum 5-hydroxytryptamine. In addition, a significant increase in the mean change rate (%) of 24-h urinary norepinephrine was observed in the chamomile (C) essential oil massage group only. Based on these results, valerian, lavender, and chamomile oils were mixed in different ratios to produce blending oils A (L:C:V=2:2:1), B (L:C:V=3:1:1) and C (L:C:V=1:3:1). The highest level of serum 5-hydroxytryptamine was observed after administering blending oil A. These results suggest that blending oil A might possess therapeutic effects against insomnia. Overall, it is hypothesized that the optimally blended essential oil will produce synergic effects when combined with hypnotic drugs.

Keywords

Acknowledgement

This work was supported by Sookmyung Women's University.

References

  1. Agatonovic-Kustrin, S., Chan, C. K. Y., Gegechkori, V. and Morton, D. W. (2020) Models for skin and brain penetration of major components from essential oils used in aromatherapy for dementia patients. J. Biomol. Struct. Dyn. 38, 2402-2411. https://doi.org/10.1080/07391102.2019.1633408
  2. Al-Sharman, A., Ismaiel, I. A., Khalil, H. and El-Salem, K. (2021) Exploring the relationship between sleep quality, sleep-related biomarkers, and motor skill acquisition using virtual reality in people with parkinson's disease: a pilot study. Front. Neurol. 12, 582611.
  3. Bedrosian, T. A. and Nelson, R. J. (2012) Pro: Alzheimer's disease and circadian dysfunction: Chicken or egg? Alzheimers. Res. Ther. 4, 25.
  4. Bemelmans, K. J., Noort, A., De Rijk, R., Middelkoop, H. A., van Kempen, G. M. and Goekoop, J. G. (2007) Plasma cortisol and norepinephrine in Alzheimer's disease: opposite relations with recall performance and stage of progression. Acta Neuropsychiatr. 19, 231-237. https://doi.org/10.1111/j.1601-5215.2006.00172.x
  5. Benmansour, S., Cecchi, M., Morilak, D. A., Gerhardt, G. A., Javors, M. A., Gould, G. G. and Frazer, A. (1999) Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. J. Neurosci. 19, 10494-10501. https://doi.org/10.1523/JNEUROSCI.19-23-10494.1999
  6. Brum, L. F., Elisabetsky, E. and Souza D. (2001) Effects of linalool on [(3)H]MK801 and [(3)H] muscimol binding in mouse cortical membranes. Phytother. Res. 15, 422-425. https://doi.org/10.1002/ptr.973
  7. Chalbot, S., Zetterberg, H., Blennow, K., Fladby, T., Andreasen, N., Grundke-Iqbal, I. and Iqbal, K. (2011) Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease. J. Alzheimers Dis. 25, 505-515. https://doi.org/10.3233/JAD-2011-101959
  8. Chen, Y., Chen, T. and Hou, R. (2022) Locus coeruleus in the pathogenesis of Alzheimer's disease: a systematic review. Alzheimer's Dement. 8, e12257.
  9. Cline, M., Taylor, J. E., Flores, J., Bracken, S., McCall, S. and Ceremuga, T. E. (2008) Investigation of the anxiolytic effects of linalool, a lavender extract, in the male Sprague-Dawley rat. AANA J. 76, 47-52.
  10. Dumont, G. J. H., De Visser, S. J., Cohen, A. F. and Van Gerven, J. M. A. (2005) Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects. Br. J. Clin. Pharmacol. 59, 495-510. https://doi.org/10.1111/j.1365-2125.2005.02342.x
  11. Elisabetsky, E., Marschner, J. and Souza, D. (1995) Effects of linalool on glutamatergic system in the rat cerebral cortex. Neurochem. Res. 20, 461-465. https://doi.org/10.1007/BF00973103
  12. Elrod, R., Peskind, E. R., DiGiacomo, L., Brodkin, K. I., Veith, R. C. and Raskind, M. A. (1997) Effects of Alzheimer's disease severity on cerebrospinal fluid norepinephrine concentration. Am. J. Psychiatry 154, 25-30. https://doi.org/10.1176/ajp.154.1.25
  13. El-Mallah, M. H. and El-Shami, S. M. (2009) Investigation of liquid wax components of Egyptian jojoba seeds. J. Oleo Sci. 58, 543- 548. https://doi.org/10.5650/jos.58.543
  14. Field, T., Field, T., Cullen, C., Largie, S., Diego, M., Schanberg, S. and Kuhn, C. (2008) Lavender bath oil reduces stress and crying and enhances sleep in very young infants. Early Hum. Dev. 84, 399-401. https://doi.org/10.1016/j.earlhumdev.2007.10.008
  15. Franke, R. and Schilcher, H. (2005) Chamomile Industrial Profiles, Taylor & Francis. 304, CRC Press, Boca Raton
  16. Gabelle, A. and Dauvilliers, Y. (2010) Editorial: sleep and dementia. J. Nutr. Health Aging 14, 201-202. https://doi.org/10.1007/s12603-010-0049-2
  17. Hardeland, R. (2012) Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. Sci. World J. 2012, 640389.
  18. Humer, E., Pieh, C. and Brandmayr, G. (2020) Metabolomics in sleep, insomnia and sleep apnea. Int. J. Mol. Sci. 21, 7244.
  19. Jalali-Heravi, M., Moazeni, R. S. and Sereshti, H. (2011) Analysis of Iranian rosemary essential oil: application of gas chromatography-mass spectrometry combined with chemometrics. J. Chromatogr. A 1218, 2569-2576 https://doi.org/10.1016/j.chroma.2011.02.048
  20. Jones, B. E. (2005) From waking to sleeping: neuronal and chemical substrates. Trends Pharmacol. Sci. 26, 578-586. https://doi.org/10.1016/j.tips.2005.09.009
  21. Keepers, G. A., Fochtmann, L. J., Anzia, J. M., Benjamin, S., Lyness, J. M., Mojtabai, R., Servis, M., Walaszek, A., Buckley, P., Lenzenweger, M. F., Young, A. S., Degenhardt, A. and Hong, S. H. (2020) The American psychiatric association practice guideline for the treatment of patients with schizophrenia. Am. J. Psychiatry 18, 493-497.
  22. Kim, C. S., Han, J. Y., Kim, S., Hong, J. T. and Oh, K. (2011) Herbs for the treatment of insomnia. Biomol. Ther. (Seoul) 19, 274-281. https://doi.org/10.4062/biomolther.2011.19.3.274
  23. Kumar, V. M., Vetrivelan, R. and Mallick, H. N. (2007) Noradrenergic afferents and receptors in the medial preoptic area: neuroanatomical and neurochemical links between the regulation of sleep and body temperature. Neurochem. Int. 50, 783-790. https://doi.org/10.1016/j.neuint.2007.02.004
  24. Lachenmeier, D. W., Emmert, J., Kuballa, T. and Sartor, G. (2006) Thujone - cause of absinthism? Forensic Sci. Int. 158, 1-8. https://doi.org/10.1016/j.forsciint.2005.04.010
  25. Lack, L. C. and Wright, H. R. (2010) Circadian rhythms and insomnia. In: Clinical Handbook of Insomnia, pp. 243-253. Humana Press, Totowa, NJ.
  26. Lee, K. B., Cho, E. and Kang, Y. S. (2014) Changes in 5-hydroxytryptamine and cortisol plasma levels in menopausal women after inhalation of clary sage oil. Phytother. Res. 28, 1599-1605. https://doi.org/10.1002/ptr.5163
  27. Lewith, G. T., Godfrey, A. D. and Prescott, P. (2005) A single-blinded, randomized pilot study evaluating the aroma of Lavandula augustifolia as a treatment for mild insomnia. J. Altern. Complement. Med. 11, 631-637. https://doi.org/10.1089/acm.2005.11.631
  28. McCall, C. and McCall, W. V. (2012) What is the role of sedating antidepressants, antipsychotics, and anticonvulsants in the management of insomnia. Curr. Psychiatry Rep. 14, 494-502. https://doi.org/10.1007/s11920-012-0302-y
  29. Michael, L. P., Michael, T. S. and Wilfred, P. (2005) Principle and Practice of Sleep medicine: Etiology And Pathophysiology of Insomnia, pp. 714-725. Elsevier.
  30. Monti, J. M. and Jantos, H. (2008) The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Prog. Brain Res. 172, 625-646. https://doi.org/10.1016/S0079-6123(08)00929-1
  31. Ohayon, M. M. (2002) Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med. Rev. 6, 97-111. https://doi.org/10.1053/smrv.2002.0186
  32. Riemann, D., Klein, T., Rodenbeck, A., Feige, B., Horny, A., Hummel, R., Weske, G., Al-Shajlawi, A. and Voderholzer, U. (2002) Nocturnal cortisol and melatonin secretion in primary insomnia. Psychiatry Res. 113, 17-27. https://doi.org/10.1016/S0165-1781(02)00249-4
  33. Riemann, D., Krone, L. B., Wulff, K. and Nissen, C. (2020) Sleep, insomnia, and depression. Neuropsychopharmacology 45, 74-89. https://doi.org/10.1038/s41386-019-0411-y
  34. Salehi, B., Upadhyay, S., Orhan, I. E., Jugran, A. K., Jayaweera, S. L. D., Dias, D. A., Sharopov, F., Taheri, Y., Martins, N., Baghalpour, N., Cho, W. C. and Sharifi-Rad, J. (2019) Therapeutic potential of α-and β-pinene: a miracle gift of nature. Biomolecules 9, 738.
  35. Setzer, W. N. (2009) Essential oils and anxiolytic aromatherapy. Nat. Prod. Commun. 4, 1305-1316.
  36. Shinomiya, K., Inoue, T., Utsu, Y., Tokunaga, S., Masuoka, T., Ohmori, A. and Kamei, C. (2005) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biol. Pharm. Bull. 28, 808-810. https://doi.org/10.1248/bpb.28.808
  37. Shinjyo, N., Waddell, G. and Green, J. (2020) Valerian root in treating sleep problems and associated disorders-a systematic review and meta-analysis. J. Evid. Based Integr. Med. 25, 2515690X20967323.
  38. Sviglin, N. K., Nedic, G., Nikolac, M., Mustapic, M., Muck-Seler, D., Borovecki, F. and Pivac, N. (2011) Insomnia, platelet serotonin and platelet monoamine oxidase in chronic alcoholism. Neurosci. Lett. 500, 172-176. https://doi.org/10.1016/j.neulet.2011.06.026
  39. Vgontzas, A. N., Tsigos, C., Bixler, E. O., Stratakis, C. A., Zachman, K., Kales, A., Vela-Bueno, A. and Chrousos, G. P. (1998) Chronic insomnia and activity of the stress system: a preliminary study. J. Psychosom. Res. 45, 21-31. https://doi.org/10.1016/S0022-3999(97)00302-4
  40. Vonderheid-Guth, B., Todorova, A., Brattstrom, A. and Dimpfel, W. (2000) Pharmacodynamic effects of valerian and hops extract combination (Ze 91019) on the quantitative-topographical EEG in healthy volunteers. Eur. J. Med. Res. 5, 139-144.
  41. Wang, C. and Holtzman, D. M. (2020) Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors. Neuropsychopharmacology 45, 104-120. https://doi.org/10.1038/s41386-019-0478-5
  42. Wang, W., Wang, Y., Guo, Q., Li, H., Wang, Z., Li, J., Li, T., Tang, T., Wang, Y., Jia, Y., Wang, Y., Zou, J., Shi, Y., Guo, D., Yang, M., Zhang, X. and Sun, J. (2022) Valerian essential oil for treating insomnia via the serotonergic synapse pathway. Front. Nutr. 9, 927434.
  43. Wheatley, D. (2005) Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. J. Psychopharmacol. 19, 414-421. https://doi.org/10.1177/0269881105053309
  44. Yang, H., Woo, J., Pae, A. N., Um, M. Y., Cho, N. C., Park, K. D., Yoon, M., Kim, J., Lee, C. J. and Cho, S. (2016) α-Pinene, a major constituent of pine tree oils, enhances non-rapid eye movement sleep in mice through GABAA-benzodiazepine receptors. Mol. Pharmacol. 90, 530-539. https://doi.org/10.1124/mol.116.105080
  45. Yang, J. Y., Wu, C. F., Wang, F., Song, H. R., Pan, W. J. and Wang, Y. L. (2003) The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. Naunyn Schmiedebergs Arch. Pharmacol. 368, 457-462. https://doi.org/10.1007/s00210-003-0843-z