Molecules and Cells

  • 제46권11호
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  • Pages.664-671
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  • 2023
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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The Role of mRNA Quality Control in the Aging of Caenorhabditis elegans

  • Hyunwoo C. Kwon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Yunkyu Bae (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) ;
  • Seung-Jae V. Lee (Department of Biological Sciences, Korea Advanced Institute of Science and Technology)
  • 투고 : 2023.06.27
  • 심사 : 2023.09.02
  • 발행 : 2023.11.30
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초록

The proper maintenance of mRNA quality that is regulated by diverse surveillance pathways is essential for cellular homeostasis and is highly conserved among eukaryotes. Here, we review findings regarding the role of mRNA quality control in the aging and longevity of Caenorhabditis elegans, an outstanding model for aging research. We discuss the recently discovered functions of the proper regulation of nonsense-mediated mRNA decay, ribosome-associated quality control, and mRNA splicing in the aging of C. elegans. We describe how mRNA quality control contributes to longevity conferred by various regimens, including inhibition of insulin/insulin-like growth factor 1 (IGF-1) signaling, dietary restriction, and reduced mechanistic target of rapamycin signaling. This review provides valuable information regarding the relationship between the mRNA quality control and aging in C. elegans, which may lead to insights into healthy longevity in complex organisms, including humans.

키워드

과제정보

We thank all Lee laboratory members for helpful comments and discussion. This research was supported by the KAIST Key Research Institutes Project (Interdisciplinary Research Group) to S.J.V.L.

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