DOI QR코드

DOI QR Code

자궁내막증의 한약 치료에 대한 동물 실험 연구 동향

Research Trends of Animal Experiment on the Herbal Medicine Treatment for Endometriosis

  • 이지영 (경희대학교 대학원 임상한의학과) ;
  • 황덕상 (경희대학교 대학원 임상한의학과) ;
  • 이진무 (경희대학교 대학원 임상한의학과) ;
  • 이창훈 (경희대학교 대학원 임상한의학과) ;
  • 장준복 (경희대학교 대학원 임상한의학과)
  • Ji-Young, Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Deok-Sang, Hwang (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jin-Moo, Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Chang-Hoon, Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jun-Bock, Jang (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2023.01.12
  • 심사 : 2023.02.24
  • 발행 : 2023.02.24

초록

Objectives: The aim of this study is to investigate the research trends of animal experiment on the herbal medicine treatment for endometriosis over the past 10 years. Methods: We searched the databases (Pubmed, Embase, Science-on) with terms as endometriosis, Korean medicine, herbal medicine and Chinese medicine. Among the results, we reviewed studies published from 2013 to 2022. Results: 26 studies were selected and analyzed. 8 single herbs and 18 complex formula were used in these studies. The most commonly used herbal medicine for endometriosis was Paeoniae Radix. Each studies showed that herbal medicine had significant effect on treating endometriosis. Conclusions: These results suggest that treating endometriosis with herbal material is effective in inhibiting ectopic lesion and angiogenesis, increasing pain threshold and apoptosis. Further research should be conducted to verify its therapeutic mechanisms and effectiveness.

키워드

참고문헌

  1. McKinnon BD, et al. Inflammation and nerve fiber interaction in endometriotic pain. Trends Endocrinol Metab. 2015; 26(1):1-10. https://doi.org/10.1016/j.tem.2014.10.003
  2. Korean Society of Obstetrics and Gynecology. Obstetrics & Gynecology Guidelines and Summary. 5th Ed. Paju:Goonja Publisher. 2021:97-107.
  3. Kim HK, et al. The estimated prevalence and incidence of endometriosis with the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC): a national population-based study. J Epidemiol. 2021;31(12):593-600. https://doi.org/10.2188/jea.JE20200002
  4. Capezzuoli T, et al. Hormonal drugs for the treatment of endometriosis. Curr Opin Pharmacol. 2022;67:102311.
  5. Becker CM, et al. ESHRE guideline: endometriosis. Human reproduction open. 2022;2022(2):hoac009.
  6. Uludag SZ, et al. Dienogest Reduces Endometrioma Volume and Endometriosis -Related Pain Symptoms. J Gynecol Obstet. 2021;41(8):1246-51. https://doi.org/10.1080/01443615.2020.1867962
  7. American College of Obstetricians and Gynecologists. Depot medroxyprogesterone acetate and bone effects. ACOG Committee Opinion No. 415. J Gynecol Obstet. 2008;112(3):727-30.
  8. Kang AR, Shin JH. Medical therapy of endometriosis to reduce the risk of recurrence. J Korean Obstet Gyneco. 2009;52(11):1093-100.
  9. Park HR, et al. Complex Korean Medicine Therapy for Hypoestrogenic Side Effects of Gonadotropin Releasing Hormone Agonist Administration to Postoperative Endometriosis Patient: A Case Report. J Korean Obstet Gyneco. 2018;31(4):188-96. https://doi.org/10.15204/JKOBGY.2018.31.4.188
  10. Tang X, et al. Chinese herbal compound prescription for Endometriosis: a protocol for systematic review and meta-analysis. Medicine. 2020;99(42):e22698.
  11. Dong P, Ling L, Hu L. Systematic review and meta-analysis of traditional Chinese medicine compound in treating infertility caused by endometriosis. Ann Palliat Med. 2021;10(12):12631-42. https://doi.org/10.21037/apm-21-3425
  12. Park JK. A Study on the Clinical Study of Periodic Treatment of Endometriosis. J Korean Obstet Gyneco. 2020;33(2):112-23. https://doi.org/10.15204/JKOBGY.2020.33.2.112
  13. Song H, et al. Korean red ginseng attenuates Di-(2-ethylhexyl) phthalate-induced inflammatory response in endometrial cancer cells and an endometriosis mouse model. J Ginseng Res. 2022;46(4):592-600. https://doi.org/10.1016/j.jgr.2021.11.006
  14. Cho MK, et al. Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis. Front Pharmacol. 2022;13:872810.
  15. Lim S, et al. Effects of Boyanghwano-Tang on the Development of Experimentally -induced Endometriosis in the Rats. J Korean Obstet Gyneco. 2010;23(3):56-77. https://doi.org/10.15204/JKOBGY.2010.23.3.056
  16. Gao Y, et al. Systemic pharmacological verification of Guizhi Fuling decoction in treating endometriosis-associated pain. J Ethnopharmacol. 2022;297:115540.
  17. Yue D, et al. Effect of Shixiao San on inflammatory factors and pain in rats with endometriosis. J Ethnopharmacol. 2022;290:115121.
  18. Chen CC, et al. Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis. Taiwan J Obstet Gynecol. 2022;61(1):70-4. https://doi.org/10.1016/j.tjog.2021.11.013
  19. Wang Y, et al. Curcumol Attenuates Endometriosis by Inhibiting the JAK2/STAT3 Signaling Pathway. Med Sci Monit. 2022;28:e934914-1-13.
  20. Zheng W, et al. Exploration of the Modulatory Property Mechanism of ELeng Capsule in the Treatment of Endometriosis Using Transcriptomics Combined With Systems Network Pharmacology. Front Pharmacol. 2021; 12:674874.
  21. Ke JY, et al. Baicalein inhibits FURIN-MT1-MMP-mediated invasion of ectopic endometrial stromal cells in endometriosis possibly by reducing the secretion of TGFB1. Am J Reprod Immunol. 2020;85(3):e13344.
  22. Takeuchi A, et al. The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages. J Reprod Immunol. 2020;139:103104.
  23. Chen ZZ, Gong X. Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting. Life Sci. 2020;240:117085. https://doi.org/10.1016/j.lfs.2019.117078
  24. Zhuang M, et al. Caulis Sargentodoxae Prescription Plays a Therapeutic Role with Decreased Inflammatory Cytokines in Peritoneal Fluid in the Rat Endometriosis Model. Evid Based Complement Alternat Med. 2020;2020:9627907.
  25. Cao Y, et al. Letrozole and the Traditional Chinese Medicine, Shaofu Zhuyu Decoction, Reduce Endometriotic Disease Progression in Rats: A Potential Role for Gut Microbiota. Evid Based Complement Alternat Med. 2020;2020:3687498.
  26. Nagira K, et al. Tokishakuyakusan, a Kampo medicine, attenuates endometriosis -like lesions and hyperalgesia in murine with endometriosis-like symptoms. Am J Reprod Immunol. 2019;82(5):e13182.
  27. Jin Y, Zheng JH. Effect of taoren-quyu decoction on endometriosis in rats. Trop J Pharm Res. 2019;18(5):1057-60. https://doi.org/10.4314/tjpr.v18i5.20
  28. Zhou J, Ding ZM, Hardiman PJ. Understanding the role of Gui-Zhi-Fu-Ling-Capsules(Chinese Medicine) for treatment of endometriosis in the rat model:Using NMR based metabolomics. Evid Based Complement Alternat Med. 2018;2018:9864963.
  29. Zhu G, et al. Shaofu Zhuyu decoction regresses endometriotic lesions in a rat model. Evid Based Complement Alternat Med. 2018;2018:3927096.
  30. Chen ZZ, Gong X. Effect of Hua Yu Xiao Zheng decoction on the expression levels of vascular endothelial growth factor and angiopoietin-2 in rats with endometriosis. Exp Ther Med. 2017; 14(6):5743-50. https://doi.org/10.3892/etm.2017.5280
  31. Cao Y, et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. PloS One. 2017;12(11):e0186520.
  32. Zhuang MF, et al. Caulis sargentodoxae prescription inhibits angiogenesis-related cytokines in a rat endometriosis model. Reprod Dev Med. 2017;1(4):189-97. https://doi.org/10.4103/2096-2924.224911
  33. Liang RN, et al. Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:6489427.
  34. Zhong R, et al. Kuntai capsule inhibited endometriosis via inducing apoptosis in a rat model. Evid Based Complement Alternat Med. 2016;2016:5649169.
  35. Yu J, et al. The effects and possible mechanisms of puerarin to treat endometriosis model rats. Evid Based Complement Alternat Med. 2015;2015:269138.
  36. Hu C, et al. Guizhi fuling capsule, an ancient Chinese formula, attenuates endometriosis in rats via induction of apoptosis. Climacteric. 2014;17(4):410-6. https://doi.org/10.3109/13697137.2013.876618
  37. Yuan DP, et al. Shikonin reduces endometriosis by inhibiting RANTES secretion and mononuclear macrophage chemotaxis. Exp Ther Med. 2014;7(3):685-90. https://doi.org/10.3892/etm.2013.1458
  38. Jiao L, et al. Effect of traditional Chinese medicine (Xiaochaihu Tang) on the expression of MMP-2 and MMP-9 in rats with endometriosis. Exp Ther Med. 2013;6(6):1385-9. https://doi.org/10.3892/etm.2013.1316
  39. Jie Z, et al. Beneficial effects of the Chinese herbal medicine Sanjie Zhentong Capsule on experimental endometriosis in rats. Chin J Nat Med. 2013;11(6):666-72. https://doi.org/10.1016/S1875-5364(13)60077-1
  40. 全國韓醫科大學本草學共同敎材編纂委員會. 本草學. 4th ED. Seoul:Young Lim Co. 2020:216-635.
  41. Jang SB, et al. The analysis of the experimental research trend of efficacy of Gyejibokryeong-hwan. J Korean Obstet Gyneco. 2016;29(2):99-112.
  42. Park KS. The efficacy and safety of Korean herbal medicine in a patient with endometrioma of the ovary: a case report. Explore. 2019;15(2):142-7. https://doi.org/10.1016/j.explore.2018.06.007
  43. Jeong CW, et al. VEGF Expression Patterns in Eutopic Endometrium of Patients with Endometriosis. Clin Exp Reprod Med. 2010;37(2):159-68.
  44. McKinnon BD, et al. Inflammation and nerve fiber interaction in endometriotic pain. Trends Endocrinol Metab. 2015;26(1):1-10. https://doi.org/10.1016/j.tem.2014.10.003
  45. Wheeler MA, et al. TNF-α/TNFR1 signaling is required for the development and function of primary nociceptors. Neuron. 2014;82(3):587-602. https://doi.org/10.1016/j.neuron.2014.04.009
  46. Park JH. Yeongmi H. The Influence of Disease-related Characteristics and Symptom Stress on Endometriosis Quality of Life of Women with Endometriosis. J Digital Convergence. 2018;16(8):243-52. https://doi.org/10.14400/JDC.2018.16.8.243