대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)

  • 제36권1호
  • /
  • Pages.23-34
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  • 2023
  • /
  • 1229-4292(pISSN)
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  • 2508-3619(eISSN)
대한한방부인과학회 (The Society of Korean Medicine Obstetrics and Gynecology)
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사상자의 세포자기살해능이 자궁경부암세포에 미치는 영향

Effects of Apoptosis of Torilis Japonica on Cervical Cancer Cell

  • 권나연 (가천대학교 한의과대학 부인과교실) ;
  • 박장경 (부산대학교 한의학전문대학원 한방부인과) ;
  • 안상현 (세명대학교 한의과대학 해부학교실) ;
  • 김기봉 (부산대학교 한의학전문대학원 한방소아과)
  • Na-Yoen, Kwon (Dept. of Obstetrics and Gynecology, College of Korean Medicine, GaChon University) ;
  • Jang-Kyung, Park (Dept. of Korean Medicine Obstetrics and Gynecology, School of Korean Medicine, Pusan National University) ;
  • Sang-Hyun, Ahn (Dept. of Anatomy, College of Korean Medicine, Semyung University) ;
  • Ki-Bong, Kim (Dept. of Korean Pediatrics, School of Korean Medicine, Pusan National University)
  • 투고 : 2023.01.12
  • 심사 : 2023.02.24
  • 발행 : 2023.02.24
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초록

Objectives: This study was conducted to confirm the anticancer effect of Torilis Japonica (TJ) on cervical cancer and to determine whether the effect was apoptosis. Methods: In this study, the effect of TJ extract on toxicity, mitochondrial morphology, nuclear morphological changes, Extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathway were investigated in HeLa cell, human cervical cancer cell. Results: The cytotoxicity, ratio of cells with nuclear changes to the total number of cells, and P38 phosphorylation increased in a concentration-dependent manner after administration of TJ extract. The length of mitochondria and ERK phosphorylation in HeLa cells decreased in a concentration-dependent manner after administration of TJ extract. Conclusions: TJ extract has an anticancer effect on cervical cancer cells, which is presumed to be due to apoptosis, and showed potential as a future cervical cancer treatment.

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과제정보

이 연구는 2019년도 정부의 재원으로 한국연구재단의 지원을 받아 수행된 기초연구사업임(No. NRF-2019R1A2C1002443).

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