Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Radiation Protection Effects of Dendranthema Zawadskii Var. Latilobum (Maxim.) Kitam. Extracts on Blood Cells, Intestine, and Uterus of Female SD Rats Irradiated with Gamma-Ray 10 Gy

구절초 추출물이 감마선 10 Gy에 조사된 암컷 SD Rat의 혈구 및 소장, 자궁에 미치는 방사선 방호효과

  • Sung-Hyun, Joo (Department of Emergency and Disaster Management, Inje University) ;
  • Hae-Suk, Kim (Department of Emergency and Disaster Management, Inje University) ;
  • Sang-Hyun, Jeong (Department of Emergency and Disaster Management, Inje University) ;
  • Jae-Gyeong, Choi (Department of Emergency and Disaster Management, Inje University) ;
  • Seong-Ok, Jin (Department of Emergency and Disaster Management, Inje University) ;
  • Byung-In, Min (Department of Nuclear Applied Engineering, Inje University)
  • 주성현 (인제대학교 재난관리학과) ;
  • 김해숙 (인제대학교 재난관리학과) ;
  • 정상현 (인제대학교 재난관리학과) ;
  • 최제경 (인제대학교 재난관리학과) ;
  • 진성옥 (인제대학교 재난관리학과) ;
  • 민병인 (인제대학교 원자력응용공학부)
  • Received : 2022.10.27
  • Accepted : 2023.01.24
  • Published : 2023.02.28
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Abstract

The purpose of this study is to see the radiation protection effect of the oral injected Dendranthema zawadskii var. latilobum (Maxim.) Kitam. extracts on the small intestine and uterus of female SD Rat as a natural radiation protection agent. The experimental group was divided into four groups: Normal Control group (NC group), Injected Dendranthema zawadskii var. latilobum (Maxim.) Kitam. extracts group (DZ group), irradiated group after injecting Dendranthema zawadskii var. latilobum (Maxim.) Kitam. extracts (DZ+IR group). The whole body of SD Rat was irradiated with gamma-ray 10Gy, and the administration of oral Dendranthema zawadskii var. latilobum (Maxim.) Kitam. Extract was 2 cc (71.56 mg/day/kg) once a day for 2 weeks. For this study, chages in blood cell levels, SOD assay, small intestine and uterus were observed. In the 21st white blood cell level, the DZ+IR group recovered to a normal level, and the IR group didn't. The IR group villus length was lower than other groups on Day 1. IR group was partially recovered, and DZ+IR group was recovered like the NC group on Day 21. In the case of the first-day endometrium, the IR group was thin and the boundary was cloudy, and the DZ+IR group was thicker and the boundary was clearer than the IR group. Day 21 IR group still did not recover, and DZ+IR group recovered like NC group. This is believed to have radiation protection effects in the blood cells and small intestine and uterus of the irradiated female SD Rat, and is expected to be useful for the study of natural radiation protection materials.

Keywords

References

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