Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Development of a High-performance COVID-19 Diagnostic Kit Employing Improved Antibody-quantum dot Conjugate

  • Seongsoo Kim (Department of Biomedical Laboratory Science, Eulji University) ;
  • Hyunsoo Na (Department of Industrial Electronics Research Institute, BK Electronics) ;
  • Hong-Geun Ahn (Department of Industrial Electronics Research Institute, BK Electronics) ;
  • Han-Sam Park (Department of Industrial Electronics Research Institute, BK Electronics) ;
  • Jaewoong Seol (Department of Biomedical Laboratory Science, Eulji University) ;
  • Il-Hoon Cho (Department of Biomedical Laboratory Science, Eulji University)
  • Received : 2023.11.22
  • Accepted : 2023.12.08
  • Published : 2023.12.31
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Abstract

This study emphasizes the importance of early diagnosis and response to COVID-19, leading to the development of a rapid diagnostic kit using quantum dots. The research focuses on finely tuning bioconjugation with quantum dots to enhance the accuracy and sensitivity of COVID-19 diagnosis. We have developed a COVID-19 rapid diagnostic kit that exhibits a sensitivity more than 50 times higher than existing COVID-19 diagnostic kits. Quantum dots enable the accurate detection of COVID-19 viral antigens even at low concentrations, providing a rapid response in the early stages of infection. The COVID-19 quantum dot diagnostic kit offers quick analysis time, utilizing the quantum properties of particles to swiftly measure COVID-19 infection for immediate response and isolation measures. Additionally, this diagnostic kit allows for multiple analyses with ease, as multiple quantum dots can detect various antigens and antibodies simultaneously in a single experiment. This efficiency enhances testing, reduces sample requirements, and lowers experimental costs. The application of this diagnostic technology is anticipated in the future for early diagnosis and monitoring of other infectious diseases.

Keywords

Acknowledgement

This work was supported by Korea institute for Advancement of Technology (KIAT) grant funded by the Korea Government (MOTIE) (P0018665).

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