Journal of information and communication convergence engineering

The Korea Institute of Information and Commucation Engineering (한국정보통신학회)
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MicroRNA-Gene Association Prediction Method using Deep Learning Models

  • Seung-Won Yoon (Department of Computer Science, Chungnam National University) ;
  • In-Woo Hwang (Department of Computer Science, Chungnam National University) ;
  • Kyu-Chul Lee (Department of Computer Science, Chungnam National University)
  • Received : 2023.07.21
  • Accepted : 2023.09.16
  • Published : 2023.12.31
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Abstract

Micro ribonucleic acids (miRNAs) can regulate the protein expression levels of genes in the human body and have recently been reported to be closely related to the cause of disease. Determining the genes related to miRNAs will aid in understanding the mechanisms underlying complex miRNAs. However, the identification of miRNA-related genes through wet experiments (in vivo, traditional methods are time- and cost-consuming). To overcome these problems, recent studies have investigated the prediction of miRNA relevance using deep learning models. This study presents a method for predicting the relationships between miRNAs and genes. First, we reconstruct a negative dataset using the proposed method. We then extracted the feature using an autoencoder, after which the feature vector was concatenated with the original data. Thereafter, the concatenated data were used to train a long short-term memory model. Our model exhibited an area under the curve of 0.9609, outperforming previously reported models trained using the same dataset.

Keywords

Acknowledgement

This work was supported by research fund of Chungnam National University.

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