DOI QR코드

DOI QR Code

A Review of the Applicability of Traditional Chinese Medicine on Coronavirus Disease 2019 Infection during Pregnancy

임신 중 코로나바이러스감염증-19 감염의 한방치료 적용 가능성에 대한 고찰

  • Park, Jin-Kyung (Dept. of Gynecology, Kyung Hee University Hospital at Gangdong) ;
  • Yun, Hyo-Won (Dept. of Gynecology, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Hye-Jung (Dept. of Gynecology, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Chang-Hoon (Dept. of Gynecology, Kyung Hee University Hospital at Gangdong) ;
  • Jang, Jun-Bock (Dept. of Gynecology, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Jin-Moo (Dept. of Gynecology, Kyung Hee University Hospital at Gangdong)
  • 박진경 (강동경희대학교 한방병원) ;
  • 윤효원 (강동경희대학교 한방병원) ;
  • 이혜정 (강동경희대학교 한방병원) ;
  • 이창훈 (강동경희대학교 한방병원) ;
  • 장준복 (경희대학교 한의과대학 부인과교실) ;
  • 이진무 (강동경희대학교 한방병원)
  • Received : 2022.10.13
  • Accepted : 2022.11.25
  • Published : 2022.11.25

Abstract

Objectives: This study was performed to review the impact of Coronavirus disease 2019 (COVID-19) infection during pregnancy and the applicability of traditional Chinese medicine (TCM) on COVID-19 infection during pregnancy. Methods: We searched 6 data bases on August, 2022 and articles about the impact of COVID-19 infection during pregnancy, TCM treatment of COVID-19 infection, TCM treatment of pregnancy common cold (姙娠 感冒) or cough (姙娠 咳嗽) were reviewed. Results: COVID-19 infection can bring out negative effects both on pregnant women and fetus. In the case of COVID-19 infection during pregnancy, the symptoms and treatment are similar to those of general COVID-19 infection, but the safety of drug intervention has not been completely verified. Herbal medicine treatment can be applied according to the severity, stage and TCM syndrome types of COVID-19 infection, but the prohibited herbs list during pregnancy and its dosage should be checked carefully. Also, when it comes to pregnancy disease, the effect of "Stabilizing Fetus" should be considered in the perspective of TCM treatment strategy. Glycyrrhizae Radix et Rhizoma, Rhizoma Atractylodis Macrocephalae, Scutellariae Radix have been widely used on COVID-19 infection and the safety of them during pregnancy have been verified. In the case of acupuncture treatment, acupoints also can be selected according to the severity, symptoms, and TCM syndrome types of COVID-19, but acupoints with strong Qi sensitivity or acupoints located in lower abdomen should be avoided during pregnancy. Conclusions: TCM treatment can be applied to COVID-19 infection during pregnancy. Clinical studies and systematic reviews of the efficacy and safety of TCM treatment on COVID-19 infection during pregnancy are required.

Keywords

Acknowledgement

이 논문은 한국보건사업진흥원의 지원을 받아 수행된 연구임(No. 20220123).

References

  1. Centers for Disease Control and Prevention. CDC COVID data tracker. United States COVID-19 cases and deaths by state[cited Jan 4, 2022]. Available from: https://covid.cdc.gov/covid-datatracker/#cases_casesper100klast7days.
  2. Yang Z, et al. Coronavirus disease 2019 (COVID-19) and pregnancy: A systematic review. J Matern Fetal Neonatal Med. 2020;35(8):1619-22. https://doi.org/10.1080/14767058.2020.1759541
  3. Rasmussen SA, et al. Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know. Am J Obstet Gynecol. 2020;222(5):415-26. https://doi.org/10.1016/j.ajog.2020.02.017
  4. Martins I, et al. EBCOG position statement on COVID-19 vaccination for pregnant and breastfeeding women. Eur J Obstet Gynecol Reprod Biol. 2021;262:256-8. https://doi.org/10.1016/j.ejogrb.2021.05.021
  5. Centers for Disease Control and Prevention. Data on COVID-19 during pregnancy: severity of maternal illness 2022[cited Jan 4, 2022]. Available from: https://covid.cdc.gov/covid-data-tracker/#pregnant-population.
  6. Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med. 2014;370(23):2211-8. https://doi.org/10.1056/NEJMra1213566
  7. Silasi M, et al. Viral infections during pregnancy. Am J Reprod Immunol. 2015;73(3):199-213. https://doi.org/10.1111/aji.12355
  8. Wei SQ, et al. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ. 2021;193(16):E540-E548. https://doi.org/10.1503/cmaj.202604
  9. Yang H, et al. Effects of SARS-CoV-2 infection on pregnant women and their infants: a retrospective study in Wuhan, China. Arch Pathol Lab Med. 2020;144(10):1217-22. https://doi.org/10.5858/arpa.2020-0232-SA
  10. Ji HL, et al. Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility. Physiol Rev. 2020;100(3):1065-75. https://doi.org/10.1152/physrev.00013.2020
  11. Durankus F, Aksu E. Effects of the COVID-19 pandemic on anxiety and depressive symptoms in pregnant women: a preliminary study. J Matern Fetal Neonatal Med. 2020;35(2):1-7.
  12. Dashraath P, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020;222(6):521-31. https://doi.org/10.1016/j.ajog.2020.03.021
  13. Knight M, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ. 2020;369:m2107. https://doi.org/10.1136/bmj.m2107
  14. Shook LL, et al. COVID-19 in pregnancy: implications for fetal brain development. Trends in Molecular Medicine. 2022;28(4):319-30. https://doi.org/10.1016/j.molmed.2022.02.004
  15. Nana M, et al. Diagnosis and management of covid-19 in pregnancy. BMJ. 2022;377:e069739. https://doi.org/10.1136/bmj-2021-069739
  16. Kim HJ. Drugs for Common Illnesses During Pregnancy. J Korean Med Assoc. 2007;50(5):440-6. https://doi.org/10.5124/jkma.2007.50.5.440
  17. Mohapatra S, Ananda P, Tripathy S. Pharmacological consideration of COVID-19 infection and vaccines in pregnancy. Journal of the Chinese Medical Association. 2022;85(5):537-42. https://doi.org/10.1097/JCMA.0000000000000712
  18. D'Souza R, et al. Pregnancy and COVID-19: pharmacologic considerations. Ultrasound in Obstetrics & Gynecology. 2021;57(2):195-203. https://doi.org/10.1002/uog.23116
  19. Cha HH, Sung WJ. Coronavirus Disease 2019 and Pregnancy. J Korean Soc Matern Child Health. 2021;25(1):10-20. https://doi.org/10.21896/jksmch.2021.25.1.10
  20. Wang W, Zhang Q, Qu F. The potential benefits of Chinese integrative medicine for pregnancy women during the COVID-19 pandemic. Integrative Medicine Research. 2020;9(3):100461. https://doi.org/10.1016/j.imr.2020.100461
  21. An X, et al. The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19. Biomedicine & Pharmacotherapy. 2021;137:111267. https://doi.org/10.1016/j.biopha.2021.111267
  22. Mukherjee AK, Chattopadhyay DJ. Potential clinical applications of phytopharmaceuticals for the in-patient management of coagulopathies in COVID-19. Phytotherapy Research. 2022;36(5):1884-913. https://doi.org/10.1002/ptr.7408
  23. Lee DYW, et al. Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis. Phytomedicine. 2021;80:153337. https://doi.org/10.1016/j.phymed.2020.153337
  24. Ang L, et al. Herbal medicine for the treatment of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Medicine. 2020;9(5):1583. https://doi.org/10.3390/jcm9051583
  25. Ang L, et al. Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines. Integrative medicine research. 2020;9(2):100407. https://doi.org/10.1016/j.imr.2020.100407
  26. Luo H, et al. Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? A review of historical classics, research evidence and current prevention programs. Chinese journal of integrative medicine. 2020;26(4):243-50. https://doi.org/10.1007/s11655-020-3192-6
  27. Ramadhani ZN, Rochmanti M, Mulawardhana P. The Safety of Herbal Used for Health Complaints during Pregnancy? A Systematic Review. Systematic Reviews in Pharmacy. 2020;11(11):1070-9.
  28. Kim YS, Lim EM, Lee HH. Analysis for 23 studies of patients that used herbal medicine during pregnancy. The Journal of Korean Obstetrics and Gynecology. 2007;20(3):185-99.
  29. Yu GH, et al. 금기약물과 관련하여 임신 중 사용된 처방에 대한 연구. Journal of Korean Medical Ki-Gong Academy. 2006;9(1):49-69.
  30. Kim DC, Baek SH. A Study on medication in febrile disease in the pregancy The journal of Korean Obstetrics & Gynecology. 2001;14(3):110-21.
  31. Jung EH, et al. A Retrospective Study of Patients that Used Herbal Medicine During Pregnancy, The Journal of Korean Obstetrics and Gynecology. 2014;27(3):79-93. https://doi.org/10.15204/JKOBGY.2014.27.3.079
  32. Jo HJ, et al. A Clinical Analysis of Patients that Used Herbal Medicine during Pregnancy for Medical Treatment. The Journal of Korean Obstetrics and Gynecology. 2008;21(4):150-8.
  33. The Association of Korean Medicine. Information on the safety of herbal medicines during pregnancy and breastfeeding[Cited Dec 10, 2020]. Available from:URL:https://www.akom.org/Down/FileDownload?boardarticle_id=609873&upload_id=2&path=%2FBoardFile%2Fpress%2F3717684661_f1aa4903_C3B7BACE2.%2BBBEABACE%2BC7D1BEE0%2BBEC8C0FCBCBA%2BC0DAB7E1C1A4B8AE.hwp&fileName=%EC%B2%A8%EB%B6%802.+%EC%82%B0%EB%B6%80+%ED%95%9C%EC%95%BD+%EC%95%88%EC%A0%84%EC%84%B1+%EC%9E%90%EB%A3%8C%EC%A0%95%EB%A6%AC.hwp.
  34. He W, et al. Discussion on the effect pathways of preventing and treating coronavirus disease 2019 by acupuncture and moxibustion from the regulation of immune inflammatory response. Chinese Acupuncture & Moxibustion. 2020;40(8):799-802.
  35. Liu WH, et al. Understanding of guidance for acupuncture and moxibustion interventions on COVID-19 (Second edition) issued by CAAM. World J Acupunct Moxibustion. 2020;30(1):1-4. https://doi.org/10.1016/j.wjam.2020.03.005
  36. Soliman N. Auricular Treatment of Maternal Depressive Disorders. Med Acupunct. 2019;31(5):259-66. https://doi.org/10.1089/acu.2018.1328
  37. Li L, et al. Chinese herbal medicines for threatened miscarriage. Cochrane Database of Systematic Reviews. 2012;(5):CD008510.
  38. Hwang SI, Yoon YJ, Park JK. A Review on Randomized Controlled Trials of Herbal Medicine Treatment for Pregnancy-induced Hypertension. The Journal of Korean Obstetrics & Gynecology. 2020;33(3):119-35.
  39. Doh TY, Lee SH, Lee JY. Review of Clinical studies of Herbal Medicine Treatment for Fetal Growth Restriction in China using CNKI Database. Journal of Korean Academy of Breastfeeding Medicine. 2018;4(1):51-72.
  40. Textbook publication committee of the Korean Acupuncture and Moxibustion Medicine Society. Textbook of the Acupuncture and Moxibustion Medicine. Paju:Jipmoondang. 2012:Vol. 1. 297, Vol. 2. 1447-51, 1469.