Anatomy and Cell Biology

  • 제55권3호
  • /
  • Pages.330-340
  • /
  • 2022
  • /
  • 2093-3665(pISSN)
  • /
  • 2093-3673(eISSN)
대한해부학회 (Korean Association of Anatomists)
권호 표지
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Regions of the human renal artery: histomorphometric analysis

  • Blanca Mompeo-Corredera (Department of Morphology, University of Las Palmas de Gran Canaria) ;
  • Pablo Hernandez-Morera (IUMA Information and Communication Systems, University of Las Palmas de Gran Canaria) ;
  • Irene Castano-Gonzalez (Department of Dermatology, Doctor Negrin University Hospital of Gran Canaria) ;
  • Maria del Pino Quintana-Montesdeoca (Department of Math, University of Las Palmas de Gran Canaria) ;
  • Natalia Mederos-Real (Department of Forensic Pathology, Institute of Legal Medicine of Las Palmas)
  • 투고 : 2022.03.30
  • 심사 : 2022.05.24
  • 발행 : 2022.09.30
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초록

The renal artery is frequently involved in the pathogenesis of vasculorenal diseases, and it is a target in kidney surgery and therapeutic techniques for refractory hypertension. However, few detailed structural studies on the human renal artery have been conducted. Using histocytochemistry, immunohistochemistry, and quantitative image analysis, the wall thickness, structure, smooth muscle cells, extracellular matrix, and proportion of elastic tissue in the tunica media of main human renal arteries were used estimated. Ninety-six tissue samples were collected from sections of the right and left main renal arteries. The results showed that the renal artery changed from an elastic vessel in its proximal segment to a muscular artery in its distal part. A critical characteristic of the renal artery was the presence of longitudinal smooth muscle cell formations in the tunica adventitia of middle and distal segments but not in the proximal part of the artery. In addition, the tunica adventitia of the renal artery showed a rich vascularization and the presence of numerous nerves profiles. The artery's regional structural and morphometric features explain that a particular arterial pathology is more frequent in a specific vessel sector than in others. In addition, those characteristics could determine a different therapeutic response attending to the arterial sector.

키워드

과제정보

We gratefully acknowledge our technical team Ms. Agueda Sosa-Martin and Ms. Fabiola Marrero-Suarez for their excellent technical work.

참고문헌

  1. Dodd GD 3rd, Tublin ME, Shah A, Zajko AB. Imaging of vascular complications associated with renal transplants. AJR Am J Roentgenol 1991;157:449-59.
  2. Hughes RJ, Scoble JE, Reidy JF. Renal angioplasty in non-atheromatous renal artery stenosis: technical results and clinical outcome in 43 patients. Cardiovasc Intervent Radiol 2004;27:435-40.
  3. Kim HJ, Do YS, Shin SW, Park KB, Cho SK, Choe YH, Choo SW, Choo IW, Kim DK. Percutaneous transluminal angioplasty of renal artery fibromuscular dysplasia: mid-term results. Korean J Radiol 2008;9:38-44.
  4. Liang P, Hurks R, Bensley RP, Hamdan A, Wyers M, Chaikof E, Schermerhorn ML. The rise and fall of renal artery angioplasty and stenting in the United States, 1988-2009. J Vasc Surg 2013;58:1331-8.e1.
  5. Townsend RR, Mahfoud F, Kandzari DE, Kario K, Pocock S, Weber MA, Ewen S, Tsioufis K, Tousoulis D, Sharp ASP, Watkinson AF, Schmieder RE, Schmid A, Choi JW, East C, Walton A, Hopper I, Cohen DL, Wilensky R, Lee DP, Ma A, Devireddy CM, Lea JP, Lurz PC, Fengler K, Davies J, Chapman N, Cohen SA, DeBruin V, Fahy M, Jones DE, Rothman M, Bohm M. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. Lancet 2017;390:2160-70.
  6. Weber MA, Mahfoud F, Schmieder RE, Kandzari DE, Tsioufis KP, Townsend RR, Kario K, Bohm M, Sharp ASP, Davies JE, Osborn JW, Fink GD, Euler DE, Cohen DL, Schlaich MP, Esler MD. Renal denervation for treating hypertension: current scientific and clinical evidence. JACC Cardiovasc Interv 2019;12:1095-105.
  7. Bohm M, Kario K, Kandzari DE, Mahfoud F, Weber MA, Schmieder RE, Tsioufis K, Pocock S, Konstantinidis D, Choi JW, East C, Lee DP, Ma A, Ewen S, Cohen DL, Wilensky R, Devireddy CM, Lea J, Schmid A, Weil J, Agdirlioglu T, Reedus D, Jefferson BK, Reyes D, D'Souza R, Sharp ASP, Sharif F, Fahy M, DeBruin V, Cohen SA, Brar S, Townsend RR. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet 2020;395:1444-51.
  8. Okamura K, Satou S, Setojima K, Shono S, Miyajima S, Ishii T, Shirai K, Urata H. Reduction of blood pressure following after renal artery adventitia stripping during total nephroureterectomy: potential effect of renal sympathetic denervation. Am J Case Rep 2018;19:567-72.
  9. Wright I. The microscopical appearances of human peripheral arteries during growth and aging. J Clin Pathol 1963;16:499-522.
  10. Osborne-Pellegrin MJ. Some ultrastructural characteristics of the renal artery and abdominal aorta in the rat. J Anat 1978;125(Pt 3):641-52.
  11. Janzen J, Lanzer P, Rothenberger-Janzen K, Vuong PN. The transitional zone in the tunica media of renal arteries has a maximal length of 10 millimetres. Vasa 2000;29:168-72.
  12. Janzen J. The microscopic transitional zone between elastic and muscular arteries. Arch Mal Coeur Vaiss 2004;97:909-14.
  13. Hinata N, Suzuki R, Ishizawa A, Miyake H, Rodriguez-Vazquez JF, Murakami G, Fujisawa M. Fetal development of the mesonephric artery in humans with reference to replacement by the adrenal and renal arteries. Ann Anat 2015;202:8-17.
  14. Mompeo B, Maranillo E, Garcia-Touchard A, Sanudo JR. The morphogenesis of the renal plexus: renal artery and sympathetic fibers. Clin Anat 2019;32:272-6.
  15. Abd Elrahim E. Computed tomography evaluation of renal artery morphometry in adults. The impact of age and gender. Saudi Med J 2020;41:34-7.
  16. Singh G, Ng YK, Bay BH. Bilateral accessory renal arteries associated with some anomalies of the ovarian arteries: a case study. Clin Anat 1998;11:417-20.
  17. Satyapal KS, Haffejee AA, Singh B, Ramsaroop L, Robbs JV, Kalideen JM. Additional renal arteries: incidence and morphometry. Surg Radiol Anat 2001;23:33-8.
  18. Standring S. Gray's anatomy. The anatomical basis of clinical practice. 40th ed. Edinburgh: Churchill Livingstone; 2008.
  19. Lee HB, Yang J, Maeng YH, Yoon SP. Bilateral multiple renal arteries with an extra-aortic origin and quadruple testicular veins. Anat Cell Biol 2019;52:518-21.
  20. Leloup AJ, Van Hove CE, Heykers A, Schrijvers DM, De Meyer GR, Fransen P. Elastic and muscular arteries differ in structure, basal NO production and voltage-gated Ca(2+)-channels. Front Physiol 2015;6:375.
  21. Borlotti A, Khir AW, Rietzschel ER, De Buyzere ML, Vermeersch S, Segers P. Noninvasive determination of local pulse wave velocity and wave intensity: changes with age and gender in the carotid and femoral arteries of healthy human. J Appl Physiol (1985) 2012;113:727-35.
  22. Matz RL, Schott C, Stoclet JC, Andriantsitohaina R. Agerelated endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products. Physiol Res 2000;49:11-8.
  23. Dougherty G. Digital image processing for medical applications. Cambridge: Cambridge University Press; 2009.
  24. Cordeiro de Amorim R, Mirkin B. Minkowski metric, feature weighting and anomalous cluster initializing in K-Means clustering. Pattern Recognit 2012;45:1061-75.
  25. Shmmala FA, Ashour W. Color based image segmentation using different versions of K-Means in two spaces. Glob Adv Res J Eng Technol Innov 2013;1:30-41.
  26. Witten IH, Frank E, Hall MA, Pal C. Algorithms: the basic methods. In: Witten IH, Frank E, Hall MA, Pal C, editors. Data Mining: Practical Machine Learning Tools and Techniques. 4th ed. Cambridge: Morgan Kaufmann Publishers; 2016. p.91-160.
  27. Madri JA, Reidy MA, Kocher O, Bell L. Endothelial cell behavior after denudation injury is modulated by transforming growth factor-beta1 and fibronectin. Lab Invest 1989;60:755-65.
  28. Stehbens WE. Focal intimal proliferation in the cerebral arteries. Am J Pathol 1960;36:289-301.
  29. Yoro T, Burnstock G. Fine structure of "intimal cushions" at branching sites in coronary arteries of vertebrates. A scanning and transmission electron microscopic study. Z Anat Entwicklungsgesch 1973;140:187-202.
  30. Stary HC, Blankenhorn DH, Chandler AB, Glagov S, Insull W Jr, Richardson M, Rosenfeld ME, Schaffer SA, Schwartz CJ, Wagner WD, Wissler RW. A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb 1992;12:120-34.
  31. Safian RD, Textor SC. Renal-artery stenosis. N Engl J Med 2001;344:431-42.
  32. Kato Y, Mizutani T, Otsuka N, Ezure H, Inoue Y. Quantitative analysis of the elastic fiber in the tunica media at the carotid bifurcation. Okajimas Folia Anat Jpn 2018;95:23-7.
  33. Sindram D, Martin K, Meadows JP, Prabhu AS, Heath JJ, McKillop IH, Iannitti DA. Collagen-elastin ratio predicts burst pressure of arterial seals created using a bipolar vessel sealing device in a porcine model. Surg Endosc 2011;25:2604-12.
  34. Kurzidim MH, Oeschger M, Sasse D. Studies on the vasa vasorum of the human renal artery. Ann Anat 1999;181:223-7.
  35. Kockx MM, Wuyts FL, Buyssens N, Van Den Bossche RM, De Meyer GR, Bult H, Herman AG. Longitudinally oriented smooth muscle cells in rabbit arteries. Virchows Arch A Pathol Anat Histopathol 1993;422:293-9.
  36. Ábraham A. Microscopic innervation of the heart and blood vessels in vertebrates including man. Oxford: Pergamon Press; 1969.
  37. Mompeo B, Maranillo E, Garcia-Touchard A, Larkin T, Sanudo J. The gross anatomy of the renal sympathetic nerves revisited. Clin Anat 2016;29:660-4.
  38. Williams JK, Heistad DD. Structure and function of vasa vasorum. Trends Cardiovasc Med 1996;6:53-7.
  39. Chistiakov DA, Ashwell KW, Orekhov AN, Bobryshev YV. Innervation of the arterial wall and its modification in atherosclerosis. Auton Neurosci 2015;193:7-11.