DOI QR코드

DOI QR Code

Renal involvement in pediatric rheumatologic diseases

  • Kim, Seong Heon (Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine)
  • Received : 2022.04.05
  • Accepted : 2022.05.06
  • Published : 2022.06.30

Abstract

Pediatric rheumatologic diseases are rare systemic diseases that can involve various organs, including the kidneys. Each rheumatologic disease can exhibit characteristic renal involvement, which requires proper treatment and diagnosis. In this review, we discuss renal involvement in classic rheumatologic diseases, including juvenile idiopathic arthritis, Sjogren's syndrome, systemic sclerosis, and juvenile dermatomyositis. Reviews addressing lupus nephritis and antineutrophil cytoplasmic antibody-associated renal disease are complex and tend to cover a wide array of topics, and thus were excluded from this review.

Keywords

References

  1. Schaller JG. The history of pediatric rheumatology. Pediatr Res 2005;58:997-1007. https://doi.org/10.1203/01.PDR.0000182823.85717.48
  2. Srinivasalu H, Riebschleger M. Medical education in pediatric rheumatology: unique challenges and opportunities. Clin Rheumatol 2020;39:643-50. https://doi.org/10.1007/s10067-019-04746-4
  3. Husserl FE, Shuler SE. Gold nephropathy in juvenile rheumatoid arthritis. Am J Dis Child 1979;133:50-2.
  4. Rovenska E, Kapeller K, Rossmann P. Gold nephropathy in rheumatoid arthritis and in juvenile chronic arthritis. Czech Med 1979;2:125-33.
  5. Koseki Y, Terai C, Moriguchi M, Uesato M, Kamatani N. A prospective study of renal disease in patients with early rheumatoid arthritis. Ann Rheum Dis 2001;60:327-31. https://doi.org/10.1136/ard.60.4.327
  6. Deschenes G, Prieur AM, Hayem F, Broyer M, Gubler MC. Renal amyloidosis in juvenile chronic arthritis: evolution after chlorambucil treatment. Pediatr Nephrol 1990;4:463-9. https://doi.org/10.1007/BF00869821
  7. Bilginer Y, Akpolat T, Ozen S. Renal amyloidosis in children. Pediatr Nephrol 2011;26:1215-27. https://doi.org/10.1007/s00467-011-1797-x
  8. Immonen K, Savolainen A, Kautiainen H, Hakala M. Longterm outcome of amyloidosis associated with juvenile idiopathic arthritis. J Rheumatol 2008;35:907-12.
  9. David J, Vouyiouka O, Ansell BM, Hall A, Woo P. Amyloidosis in juvenile chronic arthritis: a morbidity and mortality study. Clin Exp Rheumatol 1993;11:85-90.
  10. Schneider R, Passo MH. Juvenile rheumatoid arthritis. Rheum Dis Clin North Am 2002;28:503-30. https://doi.org/10.1016/S0889-857X(02)00016-9
  11. Dhillon V, Woo P, Isenberg D. Amyloidosis in the rheumatic diseases. Ann Rheum Dis 1989;48:696-701. https://doi.org/10.1136/ard.48.8.696
  12. Chantarogh S, Vilaiyuk S, Tim-Aroon T, Worawichawong S. Clinical improvement of renal amyloidosis in a patient with systemic-onset juvenile idiopathic arthritis who received tocilizumab treatment: a case report and literature review.BMC Nephrol 2017;18:159. https://doi.org/10.1186/s12882-017-0573-y
  13. Gupta A, Bagri NK, Tripathy SK, Barwad A, Phulware RH, Hari P. Successful use of tocilizumab in amyloidosis secondary to systemic juvenile idiopathic arthritis. Rheumatol Int 2020;40:153-9. https://doi.org/10.1007/s00296-019-04363-z
  14. Okuda Y, Takasugi K. Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis. Arthritis Rheum 2006;54:2997-3000. https://doi.org/10.1002/art.22118
  15. Mielants H, Van den Bosch F. Extra-articular manifestations. Clin Exp Rheumatol 2009;27(4 Suppl 55):S56-61.
  16. Adu D, Berisa F, Howie AJ, Emery P, Bacon PA, McConkey B, et al. Glomerulonephritis in rheumatoid arthritis. Br J Rheumatol 1993;32:1008-11. https://doi.org/10.1093/rheumatology/32.11.1008
  17. Bandin F, Merhenberger M, Modesto A, Brochard K, Decramer S. Steroid-responsive nephrotic syndrome in a child with juvenile idiopathic arthritis. Pediatr Nephrol 2008;23:651-4. https://doi.org/10.1007/s00467-007-0678-9
  18. Breedveld FC, Valentijn RM, Westedt ML, Weening JJ. Rapidly progressive glomerulonephritis with glomerular crescent formation in rheumatoid arthritis. Clin Rheumatol 1985;4:353-9. https://doi.org/10.1007/BF02031622
  19. Helin HJ, Korpela MM, Mustonen JT, Pasternack AI. Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis. Arthritis Rheum 1995;38:242-7. https://doi.org/10.1002/art.1780380213
  20. Gedalia A, Mendez EA, Craver R, Vehaskari M, Espinoza LR. Renal involvement in juvenile rheumatoid arthritis: report of two cases. Clin Rheumatol 2001;20:153-6. https://doi.org/10.1007/PL00011196
  21. Varma S. Juvenile rheumatoid arthritis with focal segmental glomerulosclerosis: a rare association. Pediatr Nephrol 2010;25:2189-90. https://doi.org/10.1007/s00467-010-1504-3
  22. Kari JA, Bamashmous H, Mahan JD. Steroid-sensitive nephrotic syndrome and juvenile idiopathic arthritis. Pediatr Nephrol 2002;17:975-6. https://doi.org/10.1007/s00467-002-0957-4
  23. Lipnick RN, Tsokos GC, Magilavy DB. Immune abnormalities in the pathogenesis of juvenile rheumatoid arthritis. Rheum Dis Clin North Am 1991;17:843-57. https://doi.org/10.1016/S0889-857X(21)00131-9
  24. Foster BJ, Duffy CM, Sharma AK. Systemic juvenile rheumatoid arthritis complicated by two different renal lesions. Pediatr Nephrol 1998;12:113-6. https://doi.org/10.1007/s004670050416
  25. Francois H, Mariette X. Renal involvement in primary Sjogren syndrome. Nat Rev Nephrol 2016;12:82-93. https://doi.org/10.1038/nrneph.2015.174
  26. Pessler F, Emery H, Dai L, Wu YM, Monash B, Cron RQ, et al. The spectrum of renal tubular acidosis in paediatric Sjogren syndrome. Rheumatology (Oxford) 2006;45:85-91. https://doi.org/10.1093/rheumatology/kei110
  27. Brito-Zeron P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, et al. Sjogren syndrome. Nat Rev Dis Primers 2016;2:16047. https://doi.org/10.1038/nrdp.2016.47
  28. Tucker L, Ciurtin C. Sjogren syndrome and immunoglobulin-G4 disease. In: Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, Mellins ED, Fuhlbrigge RC, editors. Textbook of pediatric rheumatology. 8th ed. Philadelphia: Elsevier; 2021. p. 417-26.
  29. Zhao J, Chen Q, Zhu Y, Zhao M, Liu J, Zhang Z, et al. Nephrological disorders and neurological involvement in pediatric primary Sjogren syndrome: a case report and review of literature. Pediatr Rheumatol Online J 2020;18:39. https://doi.org/10.1186/s12969-020-00431-y
  30. Aiyegbusi O, McGregor L, McGeoch L, Kipgen D, Geddes CC, Stevens KI. Renal disease in primary Sjogren's syndrome. Rheumatol Ther 2021;8:63-80. https://doi.org/10.1007/s40744-020-00264-x
  31. Katsifis GE, Rekka S, Moutsopoulos NM, Pillemer S, Wahl SM. Systemic and local interleukin-17 and linked cytokines associated with Sjogren's syndrome immunopathogenesis. Am J Pathol 2009;175:1167-77. https://doi.org/10.2353/ajpath.2009.090319
  32. Goules A, Geetha D, Arend LJ, Baer AN. Renal involvement in primary Sjogren's syndrome: natural history and treatment outcome. Clin Exp Rheumatol 2019;37 Suppl 118:123-32.
  33. Gu X, Su Z, Chen M, Xu Y, Wang Y. Acquired Gitelman syndrome in a primary Sjogren syndrome patient with a SLC12A3 heterozygous mutation: a case report and literature review. Nephrology (Carlton) 2017;22:652-5. https://doi.org/10.1111/nep.13045
  34. Ren H, Wang WM, Chen XN, Zhang W, Pan XX, Wang XL, et al. Renal involvement and followup of 130 patients with primary Sjogren's syndrome. J Rheumatol 2008;35:278-84.
  35. Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. J Am Soc Nephrol 1992;3:264-71. https://doi.org/10.1681/ASN.V32264
  36. Pedro-Botet J, Tomas S, Soriano JC, Coll J. Primary Sjogren's syndrome associated with Bartter's syndrome. Clin Exp Rheumatol 1991;9:210-2.
  37. Oliva-Damaso N, Oliva-Damaso E, Payan J. Acute and chronic tubulointerstitial nephritis of rheumatic causes. Rheum Dis Clin North Am 2018;44:619-33. https://doi.org/10.1016/j.rdc.2018.06.009
  38. Jung SK, Park KH, Yim HE, Yoo KH, Hong YS, Lee JW, et al. Primary Sjogren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child. Pediatr Nephrol 2010;25:567-8. https://doi.org/10.1007/s00467-009-1358-8
  39. Yoshida K, Suzuki J, Kume K, Suzuki S, Isome M, Kato K, et al. Sjogren's syndrome with membranous glomerulonephritis detected by urine screening of schoolchildren. Acta Paediatr Jpn 1996;38:533-6. https://doi.org/10.1111/j.1442-200X.1996.tb03540.x
  40. Kagan M, Bervina N, Vorobyeva O, Wouters C, Levtchenko E. Pauci-immune crescentic glomerulonephritis complicating Sjogren's syndrome in a 12-year-old girl. Pediatr Nephrol 2011;26:991-2. https://doi.org/10.1007/s00467-011-1760-x
  41. Dorfman RF, Berry GJ. Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 1988;5:329-45.
  42. Lin CY, Wu CH, Chen HA, Hsu CY, Wang LH, Su YJ. Long-term renal prognosis among patients with primary Sjogren's syndrome and renal involvement: a nationwide matched cohort study. J Autoimmun 2020;113:102483. https://doi.org/10.1016/j.jaut.2020.102483
  43. Fragoulis GE, Zampeli E, Moutsopoulos HM. IgG4-related sialadenitis and Sjogren's syndrome. Oral Dis 2017;23:152-6. https://doi.org/10.1111/odi.12526
  44. Boffa JJ, Esteve E, Buob D. Renal involvement in IgG4-related disease. Presse Med 2020;49:104017. https://doi.org/10.1016/j.lpm.2020.104017
  45. Johnson JS, Saltzman AF, Treece AL, Cost NG. A case of IgG4-related renal pseudotumor in a child with history of Wilms tumor. Urol Case Rep 2018;21:107-9. https://doi.org/10.1016/j.eucr.2018.09.016
  46. Karim F, Loeffen J, Bramer W, Westenberg L, Verdijk R, van Hagen M, et al. IgG4-related disease: a systematic review of this unrecognized disease in pediatrics. Pediatr Rheumatol Online J 2016;14:18. https://doi.org/10.1186/s12969-016-0079-3
  47. Torok KS, Stevens AM. Juvenile systemic sclerosis. In: Petty RE, Laxer RM, Lindsley CB, Wedderburn LR, Mellins ED, Fuhlbrigge RC, editors. Textbook of pediatric rheumatology. 8th ed. Philadelphia: Elsevier; 2021. p. 377-401.
  48. Chrabaszcz M, Malyszko J, Sikora M, Alda-Malicka R, Stochmal A, Matuszkiewicz-Rowinska J, et al. Renal involvement in systemic sclerosis: an update. Kidney Blood Press Res 2020;45:532-48. https://doi.org/10.1159/000507886
  49. Denton CP, Khanna D. Systemic sclerosis. Lancet 2017;390:1685-99. https://doi.org/10.1016/S0140-6736(17)30933-9
  50. Herrick AL. Vascular function in systemic sclerosis. Curr Opin Rheumatol 2000;12:527-33. https://doi.org/10.1097/00002281-200011000-00009
  51. Steen VD. Scleroderma renal crisis. Rheum Dis Clin North Am 2003;29:315-33. https://doi.org/10.1016/S0889-857X(03)00016-4
  52. Pamuk GE, Pamuk ON, Altiparmak MR, Tanverdi M, Uygun N, Yurdakul S. Secondary amyloidosis in progressive systemic sclerosis. Clin Rheumatol 2001;20:285-7. https://doi.org/10.1007/s100670170048
  53. Papadopoulou C, McCann LJ. The vasculopathy of juvenile dermatomyositis. Front Pediatr 2018;6:284. https://doi.org/10.3389/fped.2018.00284
  54. Sangeetha G, Dhanabal D, Mouttou Prebagarane S, Janarthanan M. Juvenile dermatomyositis: a case of delayed recognition with unusual complication of nephrocalcinosis. BMJ Case Rep 2021;14:e241152. https://doi.org/10.1136/bcr-2020-241152
  55. Couvrat-Desvergnes G, Masseau A, Benveniste O, Bruel A, Hervier B, Mussini JM, et al. The spectrum of renal involvement in patients with inflammatory myopathies. Medicine (Baltimore) 2014;93:33-41. https://doi.org/10.1097/MD.0000000000000015
  56. Mantoo MR, Tripathy SK, Phulware RH, Bagri NK, Hari P, Barwad A. Juvenile dermatomyositis with IgA nephropathy: case-based review. Rheumatol Int 2019;39:577-81. https://doi.org/10.1007/s00296-018-4229-4
  57. Wyatt RJ, Julian BA. IgA nephropathy. N Engl J Med 2013;368:2402-14. https://doi.org/10.1056/NEJMra1206793
  58. Stahl JL, Rutledge JC, Gordillo R. The unusual suspects: a curious case of acute kidney injury: answers. Pediatr Nephrol 2019;34:1213-5. https://doi.org/10.1007/s00467-018-4168-z
  59. Minoia F, Tibaldi J, Muratore V, Gallizzi R, Bracaglia C, Arduini A, et al. Thrombotic microangiopathy associated with macrophage activation syndrome: a multinational study of 23 patients. J Pediatr 2021;235:196-202. https://doi.org/10.1016/j.jpeds.2021.04.004