Design & Manufacturing

Korean Society of Die & Mold Engineering (한국금형공학회)
권호 표지

Study on Effect of the printing direction and layer thickness for micro-fluidic chip fabrication via SLA 3D printing

적층 방식 3차원 프린팅에 의한 미세유로 칩 제작 공정에서 프린팅 방향 및 적층 두께의 영향에 관한 연구

  • Jin, Jae-Ho (Neo Nanotech) ;
  • Kwon, Da-in (Neo Nanotech) ;
  • Oh, Jae-Hwan (Neo Nanotech) ;
  • Kang, Do-Hyun (Dept. of Nano Manufacturing Technology, Korea Institute of Machinery and Materials) ;
  • Kim, Kwanoh (Dept. of Nano Manufacturing Technology, Korea Institute of Machinery and Materials) ;
  • Yoon, Jae-Sung (Dept. of Nano Manufacturing Technology, Korea Institute of Machinery and Materials) ;
  • Yoo, Yeong-Eun (Dept. of Nano Manufacturing Technology, Korea Institute of Machinery and Materials)
  • 진재호 (네오나노텍) ;
  • 권다인 (네오나노텍) ;
  • 오재환 (네오나노텍) ;
  • 강도현 (한국기계연구원 나노공정장비연구실) ;
  • 김관오 (한국기계연구원 나노공정장비연구실) ;
  • 윤재성 (한국기계연구원 나노공정장비연구실) ;
  • 유영은 (한국기계연구원 나노공정장비연구실)
  • Received : 2022.06.22
  • Published : 2022.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Micro-fluidic chip has been fabricated by lithography process on silicon or glass wafer, casting using PDMS, injection molding of thermoplastics or 3D printing, etc. Among these processes, 3D printing can fabricate micro-fluidic chip directly from the design without master or template for fluidic channel fabricated previously. Due to this direct printing, 3D printing provides very fast and economical method for prototyping micro-fluidic chip comparing to conventional fabrication process such as lithography, PDMS casting or injection molding. Although 3D printing is now used more extensively due to this fast and cheap process done automatically by single printing machine, there are some issues on accuracy or surface characteristics, etc. The accuracy of the shape and size of the micro-channel is limited by the resolution of the printing and printing direction or layering direction in case of SLM type of 3D printing using UV curable resin. In this study, the printing direction and thickness of each printing layer are investigated to see the effect on the size, shape and surface of the micro-channel. A set of micro-channels with different size was designed and arrayed orthogonal. Micro-fluidic chips are 3D printed in different directions to the micro-channel, orthogonal, parallel, or skewed. The shape of the cross-section of the micro-channel and the surface of the micro-channel are photographed using optical microscopy. From a series of experiments, an optimal printing direction and process conditions are investigated for 3D printing of micro-fluidic chip.

Keywords

Acknowledgement

이 연구는 2022년도 산업통상자원부 및 산업기술평가관리원(KEIT) 연구비 지원에 의한 연구임(과제번호 20003670)

References

  1. B. Allegranzi., S. Bagheri Nejad., C. Combescure., W. Graafmans,. H. Attar., L. Donaldson. and D. Pittet., "Burden of endemic health-care-associated infection in developing countries: Systematic review and meta-analysis", Lancet 377, pp. 228-241, 2011. https://doi.org/10.1016/S0140-6736(10)61458-4
  2. R. A. Polin., S. Denson. and M. T. Brady., "Committee on Fetus and Newborn", Committee on Infectious Diseases, Epidemiology and diagnosis of health care-associated infections in the NICU. Pediatrics 129, e1104-e1109, 2012. https://doi.org/10.1542/peds.2012-0147
  3. M. Klompas., D. S. Yokoe. and R. A. Weinstein., "Automated surveillance of health care-associated infections", Clin. Infect. Dis. 48, pp. 1268-1275, 2009. https://doi.org/10.1086/597591
  4. Ki Soo Park., Chen-Han Huang., Kyungheon Lee., Yeong-Eun Yoo., Cesar M. Castro., Ralph Weissleder. and Hakho Lee, "Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system", Sci. Adv. 2, e1600300, 2016. https://doi.org/10.1126/sciadv.1600300
  5. Shrivastava S., Trung TQ. and Lee NE. "Recent progress, challenges, and prospects of fully integrated mobile and wearable point-of-care testing systems for self-testing", Chem Soc Rev. 49(6), 1812-66, 2020. https://doi.org/10.1039/C9CS00319C
  6. Gorgannezhad L., Stratton H. and Nguyen NT., "Microfluidic-based nucleic acid amplification systems in microbiology", Micromachines, 10(6), 408, 2019. https://doi.org/10.3390/mi10060408
  7. Petralia S., Sciuto EL. and Conoci S., "A novel miniaturized biofilter based on silicon micropillars for nucleic acid extraction", Analyst. 142(1), 140-6, 2017. https://doi.org/10.1039/C6AN02049F
  8. Wu QQ., Jin W., Zhou C., Han SH., Yang WX., Zhu QY., et al. "Integrated glass microdevice for nucleic acid purification, loop-mediated isothermal amplification, and online detection", Anal Chem. 83(9), 3336-42, 2011. https://doi.org/10.1021/ac103129e
  9. J. COOPER MCDONALD. and GEORGE M. WHITESIDES., "Poly(dimethylsiloxane) as a Material for Fabricating Microfluidic Devices", Accounts of Chemical Research 35(7): pp. 491-499, 2002. https://doi.org/10.1021/ar010110q
  10. San-Miguel A. and Lu H., "Microfluidics as a tool for C. elegans research", WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.162.1, http://www.wormbook.org., 2013.
  11. Heckele M. and Schomburg WK. "Review on micro molding of thermoplastic polymers", J Micromech Microeng., 14(3), R1-R14, 2004. https://doi.org/10.1088/0960-1317/14/3/R01