Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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Study Design and Baseline Results in a Cohort Study to Identify Predictors for the Clinical Progression to Mild Cognitive Impairment or Dementia From Subjective Cognitive Decline (CoSCo) Study

  • SeongHee Ho (Department of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Yun Jeong Hong (Department of Neurology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Jee Hyang Jeong (Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University School of Medicine) ;
  • Kee Hyung Park (Department of Neurology, College of Medicine, Gachon University Gil Medical Center) ;
  • SangYun Kim (Department of Neurology, Seoul National University College of Medicine) ;
  • Min Jeong Wang (ROA Neurology Clinic) ;
  • Seong Hye Choi (Department of Neurology, Inha University, School of Medicine) ;
  • SeungHyun Han (ROWAN Inc.) ;
  • Dong Won Yang (Department of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • Received : 2022.08.29
  • Accepted : 2022.10.28
  • Published : 2022.10.31
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Abstract

Background and Purpose: Subjective cognitive decline (SCD) refers to the self-perception of cognitive decline with normal performance on objective neuropsychological tests. SCD, which is the first help-seeking stage and the last stage before the clinical disease stage, can be considered to be the most appropriate time for prevention and treatment. This study aimed to compare characteristics between the amyloid positive and amyloid negative groups of SCD patients. Methods: A cohort study to identify predictors for the clinical progression to mild cognitive impairment (MCI) or dementia from subjective cognitive decline (CoSCo) study is a multicenter, prospective observational study conducted in the Republic of Korea. In total, 120 people aged 60 years or above who presented with a complaint of persistent cognitive decline were selected, and various risk factors were measured among these participants. Continuous variables were analyzed using the Wilcoxon rank-sum test, and categorical variables were analyzed using the χ2 test or Fisher's exact test. Logistic regression models were used to assess the predictors of amyloid positivity. Results: The multivariate logistic regression model indicated that amyloid positivity on PET was related to a lack of hypertension, atrophy of the left temporal lateral and entorhinal cortex, low body mass index, low waist circumference, less body and visceral fat, fast gait speed, and the presence of the apolipoprotein E ε4 allele in amnestic SCD patients. Conclusions: The CoSCo study is still in progress, and the authors aim to identify the risk factors that are related to the progression of MCI or dementia in amnestic SCD patients through a two-year follow-up longitudinal study.

Keywords

Acknowledgement

Statistical consultation was supported by the Department of Biostatistics of the Catholic Research Coordinating Center.

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