Journal of Marine Bioscience and Biotechnology (한국해양바이오학회지)

The Korean Society for Marine Biotechnology (한국해양바이오학회)
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Clinical safety and efficacy of a novel marine source of the long-chain omega-3 fatty acids

  • Received : 2022.03.24
  • Accepted : 2022.05.09
  • Published : 2022.06.30
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Abstract

Squid is a sustainable source of long-chain omega 3 fatty acids. This study aims to assess the safety and triglyceride-lowering efficacy of refined oil derived from the squid(Todarodes pacificus) viscera. Male and female participants with elevated fasting serum lipids (i.e., total cholesterol of ≥5.2 mmol/L or fasting serum triglyceride of ≥1.65 mmol/L) were randomly allocated to the control (n = 52) or squid oil group (n = 52), and participants in the latter group were instructed to consume 3 g of squid oil daily for 60 days. None of the subjects reported adverse events associated with the consumption of squid oil. Baseline clinical chemistry and hematological parameter values and those toward the end of the treatment period were similar, and all values were within the normal range. Fasting cholesterol and triglyceride levels in the control and squid oil groups were similar; however, toward the end of the 60 day study period, these levels significantly reduced in the squid oil group relative to those in the control group (P< 0.01). However, high-density lipoprotein-cholesterol remained unchanged in both groups. Thus, it can be inferred that squid oil is a safe source of long-chain omega-3 fatty acids and has beneficial effects on the blood lipid levels. This is the first clinical study on squid oil usage, and suggests that it could be a sustainable source of omega 3 fatty acids.

Keywords

Acknowledgement

This work was supported in part by the "Fund for Technology Development Program of Regional Industry (2004-2009)" through the Ministry of Knowledge Economy of Korea (Grant No. 10024460) and was also supported in part by the 'Development of functional food products with natural materials derived from marine resources', funded by the Ministry of Oceans and Fisheries, Korea (Grant No. 20170285). Dongwoo Industrial Co. LTD are thanked for sponsoring the study and for providing the refined squid oil.

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