대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제43권2호
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  • Pages.94-101
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  • 2022
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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멀티 리간드의 특이적 상호작용이 입자-세포간 상호작용에 미치는 영향

Effect of Specific Interaction of Multi-Ligands on the Specific Interaction between Particle and Cell

  • 윤정현 (연세대학교 미래캠퍼스 의공학부) ;
  • 이세영 (연세대학교 미래캠퍼스 의공학부)
  • Yoon, Jung Hyun (Division of Biomedical Engineering, Yonsei University) ;
  • Lee, Sei Young (Division of Biomedical Engineering, Yonsei University)
  • 투고 : 2021.12.02
  • 심사 : 2022.03.10
  • 발행 : 2022.04.30
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초록

Recent advancement of micro/nano technology enables the development of diverse micro/nano particle-based delivery systems. Due to the multi-functionality and engineerability, particle-based delivery system are expected to be a promising method for delivery to the target cell. Since the particle-based delivery system should be delivered to the various kinds of target cell, including the cardiovascular system, cancer cell etc., it is frequently decorated with multiple kinds of targeting molecule(s) to induce specific interaction to the target cell. The surface decorated molecules interact with the cell surface expressed molecule(s) to specifically form a firm adhesion. Thus, in this study, the probability of adhesion is estimated to predict the possibility to form a firm adhesion for the multi-ligand decorated particle-based delivery system.

키워드

과제정보

이 논문은 2021년도 정부(교육부)의 재원으로 한국연구재단의 지원을 받은 4단계 BK21 사업(Education and Research Center of NBIT-integrated Medical System for Personalized Healthcare-II21SS7606007)의 지원을 받아 수행됨

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