References
- Ahmed, S., Maratha, A., Butt, A.Q., Shevlin, E., and Miggin, S.M. (2013). TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15. J. Immunol. 190, 2217-2228. https://doi.org/10.4049/jimmunol.1201630
- Alvarado, A.G., Thiagarajan, P.S., Mulkearns-Hubert, E.E., Silver, D.J., Hale, J.S., Alban, T.J., Turaga, S.M., Jarrar, A., Reizes, O., Longworth, M.S., et al. (2017). Glioblastoma cancer stem cells evade innate immune suppression of self-renewal through reduced TLR4 expression. Cell Stem Cell 20, 450-461.e4. https://doi.org/10.1016/j.stem.2016.12.001
- Angkasekwinai, P. and Dong, C. (2021). IL-9-producing T cells: potential players in allergy and cancer. Nat. Rev. Immunol. 21, 37-48. https://doi.org/10.1038/s41577-020-0396-0
- Cappello, P., Curcio, C., Mandili, G., Roux, C., Bulfamante, S., and Novelli, F. (2018). Next generation immunotherapy for pancreatic cancer: DNA vaccination is seeking new combo partners. Cancers (Basel) 10, 51. https://doi.org/10.3390/cancers10020051
- Clark, E.A., Golub, T.R., Lander, E.S., and Hynes, R.O. (2000). Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406, 532-535. https://doi.org/10.1038/35020106
- Cogli, L., Progida, C., Thomas, C.L., Spencer-Dene, B., Donno, C., Schiavo, G., and Bucci, C. (2013). Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin. Acta Neuropathol. 125, 257-272. https://doi.org/10.1007/s00401-012-1063-8
- de Pooter, R.F., Schmitt, T.M., de la Pompa, J.L., Fujiwara, Y., Orkin, S.H., and Zuniga-Pflucker, J.C. (2006). Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors. J. Immunol. 176, 5267-5275. https://doi.org/10.4049/jimmunol.176.9.5267
- Deng, C.X. (2002). Roles of BRCA1 in centrosome duplication. Oncogene 21, 6222-6227. https://doi.org/10.1038/sj.onc.1205713
- Di Genua, C., Valletta, S., Buono, M., Stoilova, B., Sweeney, C., Rodriguez-Meira, A., Grover, A., Drissen, R., Meng, Y., Beveridge, R., et al. (2020). C/EBPalpha and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor. Cancer Cell 37, 690-704.e8. https://doi.org/10.1016/j.ccell.2020.03.022
- Duan, Q., Li, H., Gao, C., Zhao, H., Wu, S., Wu, H., Wang, C., Shen, Q., and Yin, T. (2019). High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway. J. Exp. Clin. Cancer Res. 38, 192. https://doi.org/10.1186/s13046-019-1209-9
- Ducreux, M., Cuhna, A.S., Caramella, C., Hollebecque, A., Burtin, P., Goere, D., Seufferlein, T., Haustermans, K., Van Laethem, J.L., Conroy, T., et al. (2015). Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 26 Suppl 5, v56-v68.
- Feng, Q., Wu, X., Li, F., Ning, B., Lu, X., Zhang, Y., Pan, Y., and Guan, W. (2017). miR-27b inhibits gastric cancer metastasis by targeting NR2F2. Protein Cell 8, 114-122. https://doi.org/10.1007/s13238-016-0340-z
- Fidler, I.J. and Kripke, M.L. (1977). Metastasis results from preexisting variant cells within a malignant tumor. Science 197, 893-895. https://doi.org/10.1126/science.887927
- Garcia, A. and Kandel, J.J. (2012). Notch: a key regulator of tumor angiogenesis and metastasis. Histol. Histopathol. 27, 151-156.
- Hahn, C.N., Chong, C.E., Carmichael, C.L., Wilkins, E.J., Brautigan, P.J., Li, X.C., Babic, M., Lin, M., Carmagnac, A., Lee, Y.K., et al. (2011). Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat. Genet. 43, 1012-1017. https://doi.org/10.1038/ng.913
- Hawkins, S.M., Loomans, H.A., Wan, Y.W., Ghosh-Choudhury, T., Coffey, D., Xiao, W., Liu, Z., Sangi-Haghpeykar, H., and Anderson, M.L. (2013). Expression and functional pathway analysis of nuclear receptor NR2F2 in ovarian cancer. J. Clin. Endocrinol. Metab. 98, E1152-E1162. https://doi.org/10.1210/jc.2013-1081
- Hennessy, E.J., Parker, A.E., and O'Neill, L.A. (2010). Targeting Toll-like receptors: emerging therapeutics? Nat. Rev. Drug Discov. 9, 293-307. https://doi.org/10.1038/nrd3203
- Hou, Y., Li, X., Li, Q., Xu, J., Yang, H., Xue, M., Niu, G., Zhuo, S., Mu, K., Wu, G., et al. (2018). STAT1 facilitates oestrogen receptor alpha transcription and stimulates breast cancer cell proliferation. J. Cell. Mol. Med. 22, 6077-6086. https://doi.org/10.1111/jcmm.13882
- Inder, S., O'Rourke, S., McDermott, N., Manecksha, R., Finn, S., Lynch, T., and Marignol, L. (2017). The Notch-3 receptor: a molecular switch to tumorigenesis? Cancer Treat. Rev. 60, 69-76. https://doi.org/10.1016/j.ctrv.2017.08.011
- Jones, S.A. and Jenkins, B.J. (2018). Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nat. Rev. Immunol. 18, 773-789. https://doi.org/10.1038/s41577-018-0066-7
- Kang, Y., Siegel, P.M., Shu, W., Drobnjak, M., Kakonen, S.M., Cordon-Cardo, C., Guise, T.A., and Massague, J. (2003). A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537-549. https://doi.org/10.1016/S1535-6108(03)00132-6
- Karreth, F.A. and Pandolfi, P.P. (2013). ceRNA cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov. 3, 1113-1121. https://doi.org/10.1158/2159-8290.CD-13-0202
- Leatherwood, J. (1998). Emerging mechanisms of eukaryotic DNA replication initiation. Curr. Opin. Cell Biol. 10, 742-748. https://doi.org/10.1016/S0955-0674(98)80117-8
- Li, D., Xie, K., Wolff, R., and Abbruzzese, J.L. (2004). Pancreatic cancer. Lancet 363, 1049-1057. https://doi.org/10.1016/S0140-6736(04)15841-8
- Liang, M., Ma, Q., Ding, N., Luo, F., Bai, Y., Kang, F., Gong, X., Dong, R., Dai, J., Dai, Q., et al. (2019). IL-11 is essential in promoting osteolysis in breast cancer bone metastasis via RANKL-independent activation of osteoclastogenesis. Cell Death Dis. 10, 353. https://doi.org/10.1038/s41419-019-1594-1
- Lin, J., Hou, K.K., Piwnica-Worms, H., and Shaw, A.S. (2009). The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. J. Immunol. 183, 1215-1221. https://doi.org/10.4049/jimmunol.0803887
- Liu, C., Shi, J., Li, Q., Li, Z., Lou, C., Zhao, Q., Zhu, Y., Zhan, F., Lian, J., Wang, B., et al. (2019a). STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer. Clin. Sci. (Lond.) 133, 645-663. https://doi.org/10.1042/CS20180816
- Liu, J., Qu, L., Meng, L., and Shou, C. (2019b). Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway. J. Exp. Clin. Cancer Res. 38, 370. https://doi.org/10.1186/s13046-019-1353-2
- Menendez-Gonzalez, J.B., Sinnadurai, S., Gibbs, A., Thomas, L.A., Konstantinou, M., Garcia-Valverde, A., Boyer, M., Wang, Z., Boyd, A.S., Blair, A., et al. (2019). Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells. Sci. Rep. 9, 12212. https://doi.org/10.1038/s41598-019-48589-0
- Meurette, O. and Mehlen, P. (2018). Notch signaling in the tumor microenvironment. Cancer Cell 34, 536-548. https://doi.org/10.1016/j.ccell.2018.07.009
- Mohan, C.D., Rangappa, S., Preetham, H.D., Chandra Nayaka, S., Gupta, V.K., Basappa, S., Sethi, G., and Rangappa, K.S. (2020). Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature. Semin. Cancer Biol. 2020 Apr 20 [Epub]. https://doi.org/10.1016/j.semcancer.2020.03.016
- Poste, G. and Fidler, I.J. (1980). The pathogenesis of cancer metastasis. Nature 283, 139-146. https://doi.org/10.1038/283139a0
- Radtke, F., MacDonald, H.R., and Tacchini-Cottier, F. (2013). Regulation of innate and adaptive immunity by Notch. Nat. Rev. Immunol. 13, 427-437. https://doi.org/10.1038/nri3445
- Ramaswamy, S., Ross, K.N., Lander, E.S., and Golub, T.R. (2003). A molecular signature of metastasis in primary solid tumors. Nat. Genet. 33, 49-54. https://doi.org/10.1038/ng1060
- Robert-Moreno, A., Espinosa, L., de la Pompa, J.L., and Bigas, A. (2005). RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development 132, 1117-1126. https://doi.org/10.1242/dev.01660
- Rosas-Salvans, M., Scrofani, J., Modol, A., and Vernos, I. (2019). DnaJB6 is a RanGTP-regulated protein required for microtubule organization during mitosis. J. Cell Sci. 132, jcs227033. https://doi.org/10.1242/jcs.227033
- Rothenberg, E.V. and Scripture-Adams, D.D. (2008). Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination. Semin. Immunol. 20, 236-246. https://doi.org/10.1016/j.smim.2008.07.006
- Roy-Luzarraga, M. and Hodivala-Dilke, K. (2016). Molecular pathways: endothelial cell FAK-a target for cancer treatment. Clin. Cancer Res. 22, 3718-3724. https://doi.org/10.1158/1078-0432.CCR-14-2021
- Ryan, N., Anderson, K., Volpedo, G., Hamza, O., Varikuti, S., Satoskar, A.R., and Oghumu, S. (2020). STAT1 inhibits T-cell exhaustion and myeloid derived suppressor cell accumulation to promote antitumor immune responses in head and neck squamous cell carcinoma. Int. J. Cancer 146, 1717-1729. https://doi.org/10.1002/ijc.32781
- Screpanti, I., Bellavia, D., Campese, A.F., Frati, L., and Gulino, A. (2003). Notch, a unifying target in T-cell acute lymphoblastic leukemia? Trends Mol. Med. 9, 30-35. https://doi.org/10.1016/S1471-4914(02)00003-5
- Siegel, R.L., Miller, K.D., and Jemal, A. (2017). Cancer statistics, 2017. CA Cancer J. Clin. 67, 7-30. https://doi.org/10.3322/caac.21387
- Siegel, R.L., Miller, K.D., and Jemal, A. (2019). Cancer statistics, 2019. CA Cancer J. Clin. 69, 7-34. https://doi.org/10.3322/caac.21551
- Singel, S.M., Cornelius, C., Batten, K., Fasciani, G., Wright, W.E., Lum, L., and Shay, J.W. (2013). A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clin. Cancer Res. 19, 2061-2070. https://doi.org/10.1158/1078-0432.CCR-13-0082
- Song, S.H., Jeon, M.S., Nam, J.W., Kang, J.K., Lee, Y.J., Kang, J.Y., Kim, H.P., Han, S.W., Kang, G.H., and Kim, T.Y. (2018). Aberrant GATA2 epigenetic dysregulation induces a GATA2/GATA6 switch in human gastric cancer. Oncogene 37, 993-1004. https://doi.org/10.1038/onc.2017.397
- Spinner, M.A., Sanchez, L.A., Hsu, A.P., Shaw, P.A., Zerbe, C.S., Calvo, K.R., Arthur, D.C., Gu, W., Gould, C.M., Brewer, C.C., et al. (2014). GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood 123, 809-821. https://doi.org/10.1182/blood-2013-07-515528
- Strebhardt, K. (2010). Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat. Rev. Drug Discov. 9, 643-660. https://doi.org/10.1038/nrd3184
- Sukhov, A., Adamopoulos, I.E., and Maverakis, E. (2016). Interactions of the immune system with skin and bone tissue in psoriatic arthritis: a comprehensive review. Clin. Rev. Allergy Immunol. 51, 87-99. https://doi.org/10.1007/s12016-016-8529-8
- Takebe, N., Nguyen, D., and Yang, S.X. (2014). Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol. Ther. 141, 140-149. https://doi.org/10.1016/j.pharmthera.2013.09.005
- Tang, X., Shi, L., Xie, N., Liu, Z., Qian, M., Meng, F., Xu, Q., Zhou, M., Cao, X., Zhu, W.G., et al. (2017). SIRT7 antagonizes TGF-beta signaling and inhibits breast cancer metastasis. Nat. Commun. 8, 318. https://doi.org/10.1038/s41467-017-00396-9
- van 't Veer, L.J., Dai, H., van de Vijver, M.J., He, Y.D., Hart, A.A., Mao, M., Peterse, H.L., van der Kooy, K., Marton, M.J., Witteveen, A.T., et al. (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536. https://doi.org/10.1038/415530a
- Vidal, S.J., Rodriguez-Bravo, V., Quinn, S.A., Rodriguez-Barrueco, R., Lujambio, A., Williams, E., Sun, X., de la Iglesia-Vicente, J., Lee, A., Readhead, B., et al. (2015). A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer. Cancer Cell 27, 223-239. https://doi.org/10.1016/j.ccell.2014.11.013
- Walden, M., Tian, L., Ross, R.L., Sykora, U.M., Byrne, D.P., Hesketh, E.L., Masandi, S.K., Cassel, J., George, R., Ault, J.R., et al. (2019). Metabolic control of BRISC-SHMT2 assembly regulates immune signalling. Nature 570, 194-199. https://doi.org/10.1038/s41586-019-1232-1
- Wang, F., Xia, X., Yang, C., Shen, J., Mai, J., Kim, H.C., Kirui, D., Kang, Y., Fleming, J.B., Koay, E.J., et al. (2018). SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy. Clin. Cancer Res. 24, 3176-3185. https://doi.org/10.1158/1078-0432.CCR-17-3435
- Zhou, X.Z. and Lu, K.P. (2016). The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target. Nat. Rev. Cancer 16, 463-478. https://doi.org/10.1038/nrc.2016.49