Animal Bioscience

  • 제35권5호
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  • Pages.639-647
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  • 2022
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  • 2765-0189(pISSN)
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  • 2765-0235(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Identification of polymorphic loci in the deiodinase 2 gene and their associations with head dimensions in geese

  • Deng, Yan (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Hu, Qian (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Tang, Bincheng (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Ouyang, Qingyuan (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Hu, Shenqiang (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Hu, Bo (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Hu, Jiwei (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • He, Hua (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University) ;
  • Chen, Guohong (Key Laboratory of Animal Genetics and Breeding and Molecular Design of Jiangsu Province, Yangzhou University) ;
  • Wang, Jiwen (Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University)
  • 투고 : 2021.08.24
  • 심사 : 2021.10.14
  • 발행 : 2022.05.01
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초록

Objective: This study was conducted to clone and compare the molecular characteristics of the deiodinase 2 (DIO2) gene between Sichuan White geese and Landes geese, and to analyze the association between polymorphisms of the DIO2 gene and head dimensions in Tianfu meat geese. Methods: The coding sequence of the DIO2 gene was cloned by polymerase chain reaction and vector ligation and aligned by DNAMAN software. A total of 350 Tianfu meat geese were used to genotype the polymorphisms of the DIO2 gene and measure the head dimensions. Association analysis between the polymorphisms of the DIO2 gene and head dimensions was carried out. Results: An 840-bp coding sequence of the DIO2 gene was obtained and comparison analysis identified four polymorphic loci between Sichuan White geese and Landes geese. Further analysis showed that the dominant alleles for the four polymorphic loci were G, G, A, and T and the frequency of the heterozygous genotype was higher than that of the homozygous genotype in Tianfu meat geese. Compared to that in the population of non-knob geese of Tianfu meat geese, the head dimensions in the population of knob geese were significantly higher except for nostril height. However, in the non-knob geese, beak width 1, beak width 2, nostril length, cranial width 1, and maxillary length had significant differences among different genotypes or haplotypes/diplotypes. Conclusion: These results suggested that polymorphisms of the DIO2 gene could be considered molecular markers to select larger heads of geese in the population of non-knob geese.

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과제정보

This work was funded by China Agricultural Research System of MOF and MARA, grant number CARS-42-4 and Key Technology Support Program of Sichuan Province, grant number 2021YFYZ0014.

참고문헌

  1. Bianco AC, da Conceicao RR. The deiodinase trio and thyroid hormone signaling. In: Plateroti M, Samarut J, editors. Thyroid hormone nuclear receptor. Methods Mol Biol 2018;1801:67-83. https://doi.org/10.1007/978-1-4939-7902-8_8
  2. Marsili A, Aguayo-Mazzucato C, Chen T, et al. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One 2011;6:e20832. https://doi.org/10.1371/journal.pone.0020832
  3. Waung JA, Bassett JH, Williams GR. Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage. Thyroid 2015;25:269-77. https://doi.org/10.1089/thy.2014.0476
  4. Bassett JHD, Boyde A, Howell P, et al. Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. Proc Natl Acad Sci USA 2010;107:7604-9. https://doi.org/10.1073/pnas.0911346107
  5. Meulenbelt I, Min JL, Bos S, et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 2008;17:1867-75. https://doi.org/10.1093/hmg/ddn082
  6. Guo TW, Zhang FC, Yang MS, et al. Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China. J Med Genet 2004;41:585-90. https://doi.org/10.1136/jmg.2004.019190
  7. Zhang K, Xi H, Wang X, et al. A family-based association study of DIO2 and children mental retardation in the Qinba region of China. J Hum Genet 2012;57:14-7. https://doi.org/10.1038/jhg.2011.121
  8. Heemstra KA, Hoftijzer H, Deure WM, et al. The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density. J Bone Miner Res 2010;25:1385-91. https://doi.org/10.1002/jbmr.27
  9. Uter JC, Kramer UM, Schols L, et al. Single nucleotide polymorphisms in thyroid hormone transporter genes MCT8, MCT10 and deiodinase DIO2 contribute to inter-individual variance of executive functions and personality traits. Ex Clin Endocrinol Diabetes 2020;128:573-81. https://doi.org/10.1055/a-1065-1786
  10. Leitch VD, Bassett JHD, Williams GR. Role of thyroid hormones in craniofacial development. Nat Rev Endocrinol 2020;16:147-64. https://doi.org/10.1038/s41574-019-0304-5
  11. Bakker B, Bikker H, Vulsma T, Randamie JS, Wiedijk BM, De Vijlder JJ. Two decades of screening for congenital hypothyroidism in The Netherlands: TPO gene mutations in total iodide organification defects (an update). J Clin Endocrinol Metab 2000;85:3708-12. https://doi.org/10.1210/jcem.85.10.6878
  12. Macchia PE, Lapi P, Krude H, et al. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat Genet 1998;19:83-6. https://doi.org/10.1038/ng0598-83
  13. Ji W, Hou lE, Yuan X, et al. Identifying molecular pathways and candidate genes associated with knob traits by transcriptome analysis in the goose (Anser cygnoides). Sci Rep 2021;11:11978. https://doi.org/10.1038/s41598-021-91269-1
  14. Deng Y, Hu S, Luo C, et al. Integrative analysis of histomorphology, transcriptome and whole genome resequencing identified DIO2 gene as a crucial gene for the protuberant knob located on forehead in geese. BMC Genomics 2021;22:487. https://doi.org/10.1186/s12864-021-07822-9
  15. Croteau W, Davey JC, Galton VA, St Germain DL. Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues. J Clin Invest 1996;98:405-17. https://doi.org/10.1172/JCI118806
  16. Gereben B, Bartha T, Tu HM, Harney JW, Rudas P, Larsen PR. Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J Biol Chem 1999;274:13768-76. https://doi.org/10.1074/jbc.274.20.13768
  17. Song S, Sorimachi K, Adachi K, Oka T. Biochemical and molecular biological evidence for the presence of type II iodothyronine deiodinase in mouse mammary gland. Mol Cell Endocrinol 2000;160:173-81. https://doi.org/10.1016/s0303-7207(99)00249-x
  18. Connor EE, Laiakis EC, Fernandes VM, Williams JL, Capuco AV. Molecular cloning, expression and radiation hybrid mapping of the bovine deiodinase type II (DIO2) and deiodinase type III (DIO3) genes. Anim Genet 2005;36:240-3. https://doi.org/10.1111/j.1365-2052.2005.01282.x
  19. Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LE. Live fast, die young: trade-offs between fitness components and sexually antagonistic selection on weaponry in Soay sheep. Evolution 2006;60:2168-81. https://doi.org/10.1111/j.0014-3820.2006.tb01854.x
  20. Constantinou A, Louca A, Mavrogenis AP. The effect of the gene for polledness on conception rate and litter size in the Damascus goat. Ann Genet Sel Anim 1981;13:111. https://doi.org/10.1186/1297-9686-13-2-111
  21. Al-Ramamneh DS, Makagon MM, Hester PY. The ability of White Leghorn hens with trimmed comb and wattles to thermoregulate. Poult Sci 2016;95:1726-35. https://doi.org/10.3382/ps/pew110
  22. Wright D, Boije H, Meadows JRS, et al. Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens. PloS Genet 2009;5:e1000512. https://doi.org/10.1371/journal.pgen.1000512
  23. Imsland F, Feng C, Boije H, et al. The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility. PloS Genet 2012;8:e1002775. https://doi.org/10.1371/journal.pgen.1002775
  24. Zhu H, Zhang Y, Bai Y, et al. Relationship between SNPs of POU1F1 gene and litter size and growth traits in Shaanbei White cashmere goats. Animals 2019;9:114. https://doi.org/10.3390/ani9030114
  25. Wang K, Cao Y, Rong Y, et al. A novel SNP in EIF2AK4 gene is associated with thermal tolerance traits in Chinese cattle. Animals 2019;9:375. https://doi.org/10.3390/ani9060375
  26. Mentuccia D, Proietti-Pannunzi L, Tanner K, et al. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes 2002;51:880-3. https://doi.org/10.2337/diabetes.51.3.880
  27. McAninch EA, Rajan KB, Evans DA, et al. A common DIO2 polymorphism and alzheimer disease dementia in African and European Americans. J Clin Endocrinol Metab 2018;103:1818-26. https://doi.org/10.1210/jc.2017-01196
  28. Jin T, Wang L, He X, et al. Association between DIO2 polymorphism and the risk of Kashin-Beck disease in the Tibetan population. J Gene Med 2019;21:e3123. https://doi.org/10.1002/jgm.3123
  29. Leiria LB, Dora JM, Wajner SM, Estivalet AA, Crispim D, Maia AL. The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance. PLoS One 2014;9:e103960. https://doi.org/10.1371/journal.pone.0103960
  30. Fallin D, Cohen A, Essioux L, et al. Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Res 2001;11:143-51. https://doi.org/10.1101/gr.148401