Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Seroprevalence of Toxoplasma gondii in cats in mainland China 2016-2020: a meta-analysis

  • Zhou, Siyu (Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University) ;
  • Sang, Ziyin (Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University) ;
  • Wang, Lijun (Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University) ;
  • Zhang, Tangjie (Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University)
  • Received : 2021.07.28
  • Accepted : 2021.09.14
  • Published : 2022.01.31
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Abstract

Background: Toxoplasma gondii can infect humans and most animals and has a very high infection rate worldwide, including in China. The number of people infected with T. gondii in China increases with the number of cats. Objectives: We investigated the seropositive rate of T. gondii in cats over the last five years and analyzed the risk factors via meta-analysis. Methods: We retrieved 20 studies, with a total of 5,158 cats, published between 2016 and 2020, used the DerSimonian-Laird model and calculated seroprevalence estimates with the variance stabilizing double arcsine transformation. Results: The overall seroprevalence rate after sinusoidal conversion was 19.9% (95% confidence interval [CI], 15.9-23.9; 966/5,158), lower than the domestic report from 1995 to 2015 (24.5%, 95% CI, 20.1-29.0). There was substantial heterogeneity among studies (χ2 = 262.32; p < 0.001; I2 = 64.6%). Regression analysis of possible heterogeneous causes and subgroup analysis showed that age and whether cats were stray or not have a significant effect on the seropositive rate. Conclusions: Articles published in recent five years suggest that the seroprevalence estimates of Toxoplasma gondii in cats has decreased. Cats, as the final host of T. gondii, are an important cause of the spread of the parasite, and this is an important concern for public health.

Keywords

Acknowledgement

This research was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions and Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009.

References

  1. Dubey JP. History of the discovery of the life cycle of Toxoplasma gondii. Int J Parasitol. 2009;39(8):877-882. https://doi.org/10.1016/j.ijpara.2009.01.005
  2. Moro JC, Moreira NM. Clinico-epidemiological and sociodemographic profile of HIV/AIDS patients who are co-infected with Toxoplasma gondii in the border region of Brazil. An Acad Bras Cienc. 2020;92(4):e20200293. https://doi.org/10.1590/0001-3765202020200293
  3. Robinson E, de Valk H, Villena I, Le Strat Y, Tourdjman M. National perinatal survey demonstrates a decreasing seroprevalence of Toxoplasma gondii infection among pregnant women in France, 1995 to 2016: impact for screening policy. Euro Surveill. 2021;26(5):1900710.
  4. Jones JL, Dargelas V, Roberts J, Press C, Remington JS, Montoya JG. Risk factors for Toxoplasma gondii infection in the United States. Clin Infect Dis. 2009;49(6):878-884. https://doi.org/10.1086/605433
  5. Deng H, Devleesschauwer B, Liu M, Li J, Wu Y, van der Giessen JW, et al. Seroprevalence of Toxoplasma gondii in pregnant women and livestock in the mainland of China: a systematic review and hierarchical meta-analysis. Sci Rep. 2018;8(1):6218. https://doi.org/10.1038/s41598-018-24361-8
  6. Gao XJ, Zhao ZJ, He ZH, Wang T, Yang TB, Chen XG, et al. Toxoplasma gondii infection in pregnant women in China. Parasitology. 2012;139(2):139-147. https://doi.org/10.1017/S0031182011001880
  7. Jiang RL, Ma LH, Ma ZR, Hou G, Zhao Q, Wu X. Seroprevalence and associated risk factors of Toxoplasma gondii among Manchu pregnant women in northeastern China. Microb Pathog. 2018;123:398-401. https://doi.org/10.1016/j.micpath.2018.07.041
  8. Belluco S, Simonato G, Mancin M, Pietrobelli M, Ricci A. Toxoplasma gondii infection and food consumption: a systematic review and meta-analysis of case-controlled studies. Crit Rev Food Sci Nutr. 2018;58(18):3085-3096. https://doi.org/10.1080/10408398.2017.1352563
  9. Gao YM, Ding H, Lamberton PH, Lu DB. Prevalence of Toxoplasma gondii in pet dogs in mainland China: a meta-analysis. Vet Parasitol. 2016;229:126-130. https://doi.org/10.1016/j.vetpar.2016.10.009
  10. Ding H, Gao YM, Deng Y, Lamberton PH, Lu DB. A systematic review and meta-analysis of the seroprevalence of Toxoplasma gondii in cats in mainland China. Parasit Vectors. 2017;10(1):27. https://doi.org/10.1186/s13071-017-1970-6
  11. Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. Assessing heterogeneity in metaanalysis: Q statistic or I2 index? Psychol Methods. 2006;11(2):193-206. https://doi.org/10.1037/1082-989X.11.2.193
  12. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629-634. https://doi.org/10.1136/bmj.315.7109.629
  13. Cong W, Meng QF, Blaga R, Villena I, Zhu XQ, Qian AD. Toxoplasma gondii, Dirofilaria immitis, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats (Felis catus) in northwest China: co-infections and risk factors. Parasitol Res. 2016;115(1):217-223. https://doi.org/10.1007/s00436-015-4738-y
  14. Cong W, Elsheikha HM, Zhou N, Peng P, Qin SY, Meng QF, et al. Prevalence of antibodies against Toxoplasma gondii in pets and their owners in Shandong province, Eastern China. BMC Infect Dis. 2018;18(1):430. https://doi.org/10.1186/s12879-018-3307-2
  15. Han Y. Investigation on the prevalence of toxoplasmosis in dogs and cats in urban area of Fuzhou. Fujian J Anim Husban Vet Med. 2019;41(6):12-13.
  16. Hou ZF, Su SJ, Liu DD, Wang LL, Jia CL, Zhao ZX, et al. Prevalence, risk factors and genetic characterization of Toxoplasma gondii in sick pigs and stray cats in Jiangsu Province, eastern China. Infect Genet Evol. 2018;60:17-25. https://doi.org/10.1016/j.meegid.2018.02.007
  17. Huang C, Chen R, Wang K, Wen F, Zheng X, Wang S. Detection of antibody IgG, PCR-RFLP genotyping and sequence variation analysis of Toxoplasma gondii from cat in Fujian. Chin Vet Sci. 2017;47(12):1562-1569.
  18. Kang YH, Cong W, Qin SY, Shan XF, Gao YH, Wang CF, et al. First report of Toxoplasma gondii, Dirofilaria immitis, and Chlamydia felis infection in stray and companion cats in northeastern and eastern China. Vector Borne Zoonotic Dis. 2016;16(10):654-658. https://doi.org/10.1089/vbz.2016.1993
  19. Li QC, Jia CL. Epidemiological investigation and analysis of Toxoplasma gondii in cats in Suqian, Jiangsu Province. Graziery Vet Sci. 2017;(10):9-10.
  20. Qin ZF, Zhuge Z. Investigation on Toxoplasma gondii infection in dogs and cats in Guilin City. Guangxi J Anim Husband Vet Med. 2018;34(2):106-107.
  21. Tian Y. Epidemiological survey of toxoplasmosis in pet dogs and cats in Fangshan District, Beijing. J Beijing Vocat Coll Agric. 2020;34(3):39-43.
  22. Wang S, Zhou Y, Niu J, Xie Q, Xiao T, Chen Y, et al. Seroprevalence of Toxoplasma gondii infection in domestic cats in central China. Parasite. 2017;24:10. https://doi.org/10.1051/parasite/2017010
  23. Wang X, Zheng X, Gong H, Liu S, Wang Y. Epidemiological risk analysis of Toxoplasma gondii infection in cats in Beijing. Chin J Vet Med. 2019;55(9):71-74.
  24. Wen X, Luo Y, Ma H, Ning M, Liu Y, Yu X, et al. Serological survey of Toxoplasma gondii in dogs and cats in Dandong area. Chin J Vet Med. 2018;54(12):50-52.
  25. Wu BT, Zhao HT. Investigation on Toxoplasma gondii infection in pet cats and dogs in Zunyi City. Guizhou J Anim Husband Vet Med. 2018;42(4):45-47.
  26. Xia CF, Gao L, Wei B, Tian T. Epidemiological investigation of toxoplasmosis of dogs and cats in Yining City. Anhui Acad Agric Sci. 2018;46(3):71-73.
  27. Xu L, Yuan J, Wen G, Luo B, Xie X, He T, et al. Investigation and study on Toxoplasma gondii infection in dogs, cats and pigs in Guiyang City in 2017. Guizhou J Anim Husband Vet Med. 2018;42(5):17-20.
  28. Yang YR, Feng YJ, Lu YY, Dong H, Li TY, Jiang YB, et al. Antibody detection, isolation, genotyping, and virulence of Toxoplasma gondii in captive felids from China. Front Microbiol. 2017;8:1414. https://doi.org/10.3389/fmicb.2017.01414
  29. Ying Z, Huang S, Chen D, Wang C, Gong L, Hu X, et al. Epidemiological investigation on toxoplasmosis of stray cats in West Lake scenic area. Zhejiang J Anim Sci Vet Med. 2018;43(4):19-21.
  30. Yu HJ, Jia Y, Zhu TL, Pan CM, Shen CC. Seroepidemiological survey of toxoplasmosis in dogs and cats in Jiaxing City. Today Anim Husban Vet Med. 2018;34(11):8-9.
  31. Yu SS, Qian WF, Xu JH, Liu Q. Detection and analysis of Toxoplasma and Neospora infection in dogs and cats in Beijing area. Chin J Vet Med. 2016;52(9):31-34.
  32. Zhuo G, Zhou H, Lu W, Wei N, Liu J, Gao X. Investigation and prevention of Toxoplasma gondii infection in pets in Taizhou area. Jiangsu Agricu Sci. 2019;47(28):191-194.
  33. Gebremedhin EZ, Tadesse G. A meta-analysis of the prevalence of Toxoplasma gondii in animals and humans in Ethiopia. Parasit Vectors. 2015;8(1):291. https://doi.org/10.1186/s13071-015-0901-7
  34. Boughattas S, Behnke J, Sharma A, Abu-Madi M. Seroprevalence of Toxoplasma gondii infection in feral cats in Qatar. BMC Vet Res. 2017;13(1):26.
  35. Shuralev EA, Shamaev ND, Mukminov MN, Nagamune K, Taniguchi Y, Saito T, et al. Toxoplasma gondii seroprevalence in goats, cats and humans in Russia. Parasitol Int. 2018;67(2):112-114. https://doi.org/10.1016/j.parint.2017.10.014
  36. Matsuu A, Yokota SI, Ito K, Masatani T. Seroprevalence of Toxoplasma gondii in free-ranging and feral cats on Amami Oshima Island, Japan. J Vet Med Sci. 2017;79(11):1853-1856. https://doi.org/10.1292/jvms.17-0359
  37. Jung BK, Song H, Lee SE, Kim MJ, Cho J, Shin EH, et al. Seroprevalence and risk factors of Toxoplasma gondii infection among cat sitters in Korea. Korean J Parasitol. 2017;55(2):203-206. https://doi.org/10.3347/kjp.2017.55.2.203
  38. Gu Y, Wang Z, Cai Y, Li X, Wei F, Shang L, et al. A comparative study of Toxoplasma gondii seroprevalence in mink using a modified agglutination test, a Western blot, and enzyme-linked immunosorbent assays. J Vet Diagn Invest. 2015;27(5):616-620. https://doi.org/10.1177/1040638715596033
  39. Gong QL, Li J, Li D, Tian T, Leng X, Li JM, et al. Seroprevalence of Toxoplasma gondii in cattle in China from 2010 to 2019: a systematic review and meta-analysis. Acta Trop. 2020;211:105439. https://doi.org/10.1016/j.actatropica.2020.105439
  40. Fu X, Feng Y, Liang H, Yang Y. Genotypes and pathogenesis of Toxoplasma gondii isolates in China. Chin J Zoonoses. 2015;31(7):669-673.