DOI QR코드

DOI QR Code

Three Cases of Post-Covid-19 Dry Cough Treated with Maekmundong-tang

COVID-19 이후 후유장애로 발생한 마른기침에 대한 맥문동탕 치험 3례

  • Yeong-seo, Lee (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Da-jung, Ha (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Kyoung-min, Kim (Dept. of Korean Internal Medicine, Dong-Eui University)
  • 이영서 (동의대학교 부속 한방병원 한방내과) ;
  • 하다정 (동의대학교 부속 한방병원 한방내과) ;
  • 김경민 (동의대학교 부속 한방병원 한방내과)
  • Received : 2022.09.15
  • Accepted : 2022.11.28
  • Published : 2022.12.30

Abstract

Objective: The purpose of this study was to report three cases of post-COVID-19 dry cough that persisted even after taking Western medicine but was successfully treated with Maekmundong-tang. Methods: Three patients who were treated with Maekmundong-tang from March to June 2022 were selected from patients who visited Dong-Eui University Korean Medicine Hospital with post-Covid-19 dry cough. Jeil Maekmundong-tang Ext. granules were used to improve the cough. The effect of the treatment was evaluated using a visual analog scale, cough symptom score, and cough assessment test. Results: After the treatment, Cases 1, 2, and 3 showed decreases from 90 to 30, 65 to 0, and 70 to 20, respectively, for the visual analog scale score, decreases from 9 to 3, 5 to 0, and 5 to 3, respectively, for the cough symptom score, and decreases from 20 to 4, 9 to 1, and 8 to 3, respectively, for the cough assessment test score. Conclusion: Maekmundong-tang provided an effective improvement in the post-COVID-19 dry cough that persisted even after taking Western medicine.

Keywords

References

  1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China. N Engl J Med 2020; 382(8):727-33. https://doi.org/10.1056/NEJMoa2001017
  2. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int
  3. Lee SU, Park JE, Lee YJ, Kim SH, Lee JG. A Case Report of Taeeumin with Post COVID-19 Syndrome. J Sasang Constitut Med 2021;33(4):32-42. https://doi.org/10.7730/JSCM.2021.33.4.32
  4. Carfi A, Bernabei R, Landi F; Gemelli Against COVID-19 Post-Acute Care Study Group. Persistent Symptoms in Patients After Acute COVID-19. JAMA 2020;324(6):603-5. https://doi.org/10.1001/jama.2020.12603
  5. Kim YJ. COVID-19 and Long-Term Sequelae. The Korean Journal of Medicine 2022;97(1):23-7. https://doi.org/10.3904/kjm.2022.97.1.23
  6. The Association of Korean Medicine. COVID-19 telemedicine guide of Korean medicine(KM telemedicine center). Seoul: The Association of Korean Medicine; 2020, p. 17-9.
  7. Lee KE, Jeong SH, Jeong MJ, Choi YM, Song MD, Jang IS. Review on Herbal Medicine Treatment for Late Complications of COVID-19 Patients. J Int Korean Med 2021;42(1):53-66. https://doi.org/10.22246/jikm.2021.42.1.53
  8. Lee SW, Kim TH, Lee EJ, Jung IC, Park YC. A Case Report on a Patient with Late Complications of COVID-19 Complaining of Dyspnea Treated with Korean Medicine Pulmonary Rehabilitation. J Korean Med 2022;43(1):171-9. https://doi.org/10.13048/jkm.22013
  9. The Korean Academy of Tuberculosis and Respiratory Diseases. Cough treatment guideline. Seoul: The Korean Academy of Tuberculosis and Respiratory Diseases; 2020, p. 38-40.
  10. Hsu JY, Stone RA, Logan-Sinclair RB, Worsdell M, Busst CM, Chung KF. Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder. Eur Respir J 1994;7(7):1246-53. https://doi.org/10.1183/09031936.94.07071246
  11. Moreno-Perez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jimenez J, et al. Post-acute covid-19 syndrome. Incidence and risk factors: A mediterranean cohort study. Journal of Infection 2021;82(3):378-83.
  12. Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nat Med 2021;27(4):601-15. https://doi.org/10.1038/s41591-021-01283-z
  13. SeyedAlinaghi S, Afsahi AM, MohsseniPour M, Behnezhad F, Salehi MA, Barzegary A, et al. Late complications of covid-19; a systematic review of current evidence. Archives of academic emergency medicine 2021;9(1):e14.
  14. Song WJ, Hui CKM, Hull JH, Birring SS, McGarvey L, Mazzone SB, et al. Confronting COVID-19-associated cough and the post-COVID syndrome: role of viral neurotropism, neuroinflammation, and neuroimmune responses. Lancet Respir Med 2021;9(5):533-44. https://doi.org/10.1016/S2213-2600(21)00125-9
  15. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-62. https://doi.org/10.1016/s0140-6736(20)30566-3
  16. Chopra V, Flanders SA, O'Malley M, Malani AN, Prescott HC. Sixty-day outcomes among patients hospitalized with COVID-19. Ann Intern Med 2020;11:M20-5661.
  17. Goertz YMJ, Van Herck M, Delbressine JM, Vaes AW, Meys R, Machado FVC, et al. Persistent symptoms 3 months after a SARS-CoV-2 infection: the post-COVID-19 syndrome? ERJ Open Res 2020;6(4):00542-2020.
  18. Irwin RS, Madison JM. Anatomical diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease. Am J Med 2000;108(4a):126S-130S.
  19. Kwon NH, Oh MJ, Min TH, Lee BJ, Choi DC. Causes and clinical features of subacute cough. Chest 2006;129(5):1142-7. https://doi.org/10.1378/chest.129.5.1142
  20. Liu M, Gao Y, Yuan Y, Yang K, Shi S, Zhang J, et al. Efficacy and Safety of Integrated Traditional Chinese and Western Medicine for Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis. Pharmacol Res 2020;158:104896.
  21. Fan AY, Gu S, Alemi SF. Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. J Integr Med 2020;18(5):385-94.
  22. 전국한의과대학폐계내과학교실편저. 동의폐계내과학. 서울: 나도문화사; 2007, p. 143-6.
  23. Roh YL, Choi JY, Lee SH, Kim JH, Jung HJ, Jung SK. Clinical Effects of Chungin-troche As an Adjuctive Medicine with Chronic Cough Patients. J Korean Med 2008;29(3):716-29.
  24. 張機. 金匱要略. 북경: 인민위생출판사; 1998, p. 192-3.
  25. Kim HW, Yang SY, Kim MH, Namgung U, Park YC. Analysis of studies on Maekmundong-tang. Daejeon Univ Res Inst Orient Med J 2011;19(2):165-71.
  26. 許浚. 東醫寶鑑. 서울: 남산당; 1986, p. 476-7.
  27. Hanuiguadaehak bangjehakgyosil. Bangjehak. Seoul: Youngrimsa; 2003, p. 476-7.
  28. Irifune K, Hamada H, Ito R, Katayama H, Watanabe A, Kato A, et al. Antitussive effect of bakumondoto a fixed kampo medicine (six herbal components) for treatment of post-infectious prolonged cough: controlled clinical pilot study with 19 patients. Phytomedicine 2011;18(8-9):630-3. https://doi.org/10.1016/j.phymed.2011.02.017
  29. Watanabe N, Cheng G, Fukuda T. Effects of Bakumondo-to (Mai-Men-Dong-Tang) on cough sensitivity to capsaicin in asthmatic patients with cough hypersensitivity. Arerugi 2003;52(5):485-91.
  30. Kim HW, Yang SY, Kim MH, Namgung U, Park YC. Protective Effects of Maekmundong-tang on Elastase-induced Lung Injury. J Korean Oriental Med 2011;32(2):63-78.
  31. Lee SS, Jung SK, Rhee HK. Effects of Maecmoondongtang on the Pulmonary Function of SO2-Exposed Rats. Journal of Korean Oriental Medicine 1994;15(2):173-83.
  32. Sung HK, Min SY, Kim JH. Effect of Macmundongtang on Production and Secretion of Respiratory Mucus. J Pediatrics of Korean Medicine 2013;27(1):69-81.