Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Vasodilatory Effect of Complex Saponin Extracted from Platycodon grandiflorum and Glycyrrhiza uralensis Mixture Extract

  • Jung-Hwan, Nam (Highland Agriculture Research Institute, National Institute of Crop Science Rural Development Administration)
  • Received : 2022.10.18
  • Accepted : 2022.11.02
  • Published : 2022.12.01
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Abstract

Platycodon grandiflorum and Glycyrrhiza uralensis contain several bioactive compounds, such as saponin, oleanolic acid, and flavone. P. grandiflorum and G. uralensis have traditionally been used to treat disorders related to blood pressure, diabetes, and counteracting poison, and they have antinociceptive and antiinflammatory properties. However, the validity of complex saponin's vasodilatory effect has not been scientifically investigated. Therefore, this study explores the vasodilatory effect of complex saponin extracted from P. grandiflorum and G. uralensis mixture extract on rabbit carotid arteries. To this end, arterial rings with intact or damaged endothelium were used in an organ bath experiment and contracted by endothelin. Complex saponins, the major active constituents of P. grandiflorum and G. uralensis mixture extract, exhibited a moderate vasodilatory effect on the rabbit's basilar arteries. Therefore, treatment with complex saponin extracted from P. grandiflorum and G. uralensis mixture extract may selectively accelerate cerebral blood flow through basilar arterial dilation. Overall, the findings suggest that the extracted complex saponins can serve as vasodilator sources.

Keywords

Acknowledgement

This study was carried out with the support of the Rural Development Administration's unique project (Task name: bioactivity analysis and food material development of byproducts of domestically grown potato varieties, Task number: PJ0160 52012022).

References

  1. Bak, M.J., J.H. Jeong, H.S. Kang, K.S. Jin, O.K. Seon and W.S. Jeong. 2009. Cedrela sinensis leaves suppress oxidative stress and ex pressions of iNOS and COX-2 via MAPK signaling pathways in RAW 264.7 cells. J. Food Sci. Nutr. 14:269-276 (in Korean).
  2. Busch, L., M. Wald, L. Sterin-Borda and E. Borda. 2000. Fluoxetine modulates norepinephrine contractile effect on rat vas deferens. Pharmacol. Res. 41:39-45. https://doi.org/10.1006/phrs.1999.0559
  3. Cauvin, C., R. Loutzenhiser and C. van Breemen. 1983. Mechanism of calcium-antagonist induced vasodilation. Annu. Rev. Pharmacol. 23:373-396. https://doi.org/10.1146/annurev.pa.23.040183.002105
  4. Garcia-Colunga, J., J.N. Awad and R. Miledi. 1997. Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac). PNASU. 94:2041-2044. https://doi.org/10.1073/pnas.94.5.2041
  5. Hong, S.J., H.S. Cho and M.G. Lee. 2022. Effects of aerobic exercise intensity on post-exercise blood pressure and cardiovascular function in prehypertensive men in their 30s. Korean J. Sport Sci. 33:169-179 (in Korean). https://doi.org/10.24985/kjss.2022.33.2.169
  6. Huang, Y. 1996. Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle. Br. J. Pharmacol. 117:533-539. https://doi.org/10.1111/j.1476-5381.1996.tb15223.x
  7. Jagadesh, S.R. and M.N. Subhash. 1998. Effect of antidepressants on intracellular Ca2+ mobilization in human frontal cortex. Biol. Psychiatery 44:617-621. https://doi.org/10.1016/S0006-3223(98)00024-9
  8. Ji, J.G. 2016. The convergence study on the effects of white ginseng complex extracts on OVA-induced allergic asthma in mice. J. Digit. Converg. 14:317-323 (in Korean). https://doi.org/10.14400/JDC.2016.14.6.317
  9. Karaki, H., H. Ozaki, M. Hori, M. Mitsui-Saito, K. Amano, K. Harada, S. Miyamoto, H. Nakazawa, K.J. Won and K. Sato. 1997. Calcium movements, distribution, and functions in smooth muscle. Pharmacol. Rev. 49:157-230.
  10. Kim, J.H. and E.J. Kim. 2018. Evaluation of anti-oxidative, anti-thrombin, anti-invasive and pro-apoptotic activities of Paeonia japonica. Korean J. Plant Res. 33:153-162 (in Korean). https://doi.org/10.7732/KJPR.2020.33.3.153
  11. Kim, S.A., E.S. Jang, A.Y. Lee, S.J. Lee and J.H. Kim. 2020. Anti-inflammatory and anti-oxidant effects of oxypaeoniflorin, paeoniflorin and Paeonia lactiflora cv. 'Red Charm' flower petal extracts in macrophage cells. Korean J. Plant Res. 33:153-162 (in Korean). https://doi.org/10.7732/KJPR.2020.33.3.153
  12. Lavoie, P.A., G. Beauchamp and R. Elie. 1997. Atypical antidepressants inhibit depolarization-induced calcium uptake in rat hippocampus synaptosomes. Can. J. Physiol. Pharmacol. 75:983-987. https://doi.org/10.1139/cjpp-75-8-983
  13. Leung, E., L.K. Walsh, M.T. Pulido-Rios and R.M. Eglen. 1996. Characterization of putative 5-HT7 receptors mediating direct relaxation in cynomolgus monkey isolated jugular vein. Br. J. Pharmacol. 117:926-930. https://doi.org/10.1111/j.1476-5381.1996.tb15282.x
  14. Li, Q., M.S. Brownfield, G. Battaglia, T.M. Cabrera, A.D. Levy, P.A. Rittenhouse and L. D. van de Kar. 1993. Longterm treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1- piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopro pane HCl (DOI). J. Pharmacol. Exp. Ther. 266:836-844.
  15. Lucchelli, A., M.G. Santagostino-Barbone, E. Masoero, P. Baiardi and M. Tonini. 1999. Influence of fluoxetine and litoxetine on 5-HT4 receptor-mediated relaxation in the rat isolated oesophagus. Fundam. Clin. Pharmacol. 13:330-336. https://doi.org/10.1111/j.1472-8206.1999.tb00352.x
  16. Nam, J.H. 2020. Vasodilatation effect of kirenol isolated from Sigesbeckia pubescens. Korean J. Plant Res. 33:467-475 (in Korean). https://doi.org/10.7732/KJPR.2020.33.5.467
  17. Ni, Y.G. and R. Miledi. 1997. Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). PNASU. 94:2036-2040. https://doi.org/10.1073/pnas.94.5.2036
  18. Pacher, P., Z. Ungvari, V. Kecskemeti, T. Friedmann and S. Furst. 2001. Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle. Can. J. Physiol. Pharmacol. 79:580-584. https://doi.org/10.1139/y01-030
  19. Pancrazio, J.J., G.L. Kamatchi, A.K. Roscoe and C. 3rd. Lynch. 1998. Inhibition of neuronal Na+ channels by antidepressant drugs. J. Pharmacol. Exp. Ther. 284:208-214.
  20. Park, B.G., S.C. Kwon, G.M. Park, J.Y. Ham, W.S. Shin and S.J. Lee. 2008. Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits. Bioorg. Med. Chem. Lett. 18:6324-6326. https://doi.org/10.1016/j.bmcl.2008.10.103
  21. Park, S.Y. and S.S. Park. 2020. Inhibitory effect of fermented and non-fermented citrus kombucha on postprandial hyperglycemia and hypertension. J. Korean Soc. Food Sci. Nutr. 49:206-211 (in Korean). https://doi.org/10.3746/jkfn.2020.49.2.206
  22. Pitt, B.R., W. Weng, A.R. Steve, R.D. Blakely, I. Reynolds and P. Davies. 1994. Serotonin increases DNA synthesis in rat proximal and distal pulmonary vascular smooth muscle cells in culture. Am. J. Physiol. 266:178-186. https://doi.org/10.1152/ajplung.1994.266.2.L178
  23. Reeves, J.J., K.T. Bunce and P.P. Humphrey. 1991. Investigation into the 5-hydroxy tryptamine receptor mediating smooth muscle relaxation in the rat oesophagus. Br. J. Pharmacol. 103:1067-1072. https://doi.org/10.1111/j.1476-5381.1991.tb12301.x
  24. Shin, H.M. 2000. Effects of Siegesbeckia glabrescens on the vascular relaxation and antioxidative status. J. Korean Oriental Med. 21:77-83 (in Korean).
  25. Tuladhar, B.R., B. Costall and R.J. Naylor. 1996. Pharmacological characterization of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum. Br. J. Pharmacol. 119: 303-310. https://doi.org/10.1111/j.1476-5381.1996.tb15986.x
  26. Tytgat, J., C. Maertens and P. Daenens. 1997. Effect of fluoxetine on a neuronal, voltage-dependent potassium channel. Br. J. Pharmacol. 122:1417-1424. https://doi.org/10.1038/sj.bjp.0701545
  27. Velasco, A., C. Alamo, J. Hervas and A. Carvajal. 1997. Effects of fluoxetine hydro chloride and fluvoxamine maleate on different preparations of isolated guinea pig and rat organ tissues. Gen. Pharmacol. 28:509-512. https://doi.org/10.1016/S0306-3623(96)00274-1
  28. Villazon, M., J.F. Padin, M.I. Cadavid, M.J. Enguix, H. Tristan, F. Orallo and M.I. Loza. 2002. Functional characterization of serotonin receptors in rat isolated aorta. Biol. Pharm. Bull. 25:584-590. https://doi.org/10.1248/bpb.25.584
  29. Yang, K.M., S.M. Song, D.S. Lee, W.J. Yoon, C.S. Kim and C.S. Kim. 2019. Anti-inflammatory and anti-atopic effects of crude extracts and solvent fractions of Phormium tenax leaf. Korean J. Plant Res. 32:433-441 (in Korean).