BMB Reports

생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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Multiplexed targeting of microRNA in stem cell-derived extracellular vesicles for regenerative medicine

  • Song, Byeong-Wook (Institute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary's Hospital) ;
  • Oh, Sekyung (Department of Medical Science, College of Medicine, Catholic Kwandong University) ;
  • Chang, Woochul (Department of Biology Education, College of Education, Pusan National University)
  • 투고 : 2021.11.23
  • 심사 : 2022.01.10
  • 발행 : 2022.02.28
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초록

Regenerative medicine is a research field that develops methods to restore damaged cell or tissue function by regeneration, repair or replacement. Stem cells are the raw material of the body that is ultimately used from the point of view of regenerative medicine, and stem cell therapy uses cells themselves or their derivatives to promote responses to diseases and dysfunctions, the ultimate goal of regenerative medicine. Stem cell-derived extracellular vesicles (EVs) are recognized as an attractive source because they can enrich exogenous microRNAs (miRNAs) by targeting pathological recipient cells for disease therapy and can overcome the obstacles faced by current cell therapy agents. However, there are some limitations that need to be addressed before using miRNA-enriched EVs derived from stem cells for multiplexed therapeutic targeting in many diseases. Here, we review various roles on miRNA-based stem cell EVs that can induce effective and stable functional improvement of stem cell-derived EVs. In addition, we introduce and review the implications of several miRNA-enriched EV therapies improved by multiplexed targeting in diseases involving the circulatory system and nervous system. This systemic review may offer potential roles for stem cell-derived therapeutics with multiplexed targeting.

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과제정보

This work was supported by a 2-Year Research Grant of Pusan National University.

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