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Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus

  • Yeong Chan, Ryu (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • You-rin, Kim (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Jiyeon, Park (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Sehee, Choi (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Geon-Uk, Kim (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Eunhwan, Kim (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Yumi, Hwang (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Heejene, Kim (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Soon Sun, Bak (Department of Immunology, School of Medicine, Kyungpook National University) ;
  • Jin Eun, Lee (Department of Immunology, School of Medicine, Kyungpook National University) ;
  • Young Kwan, Sung (Department of Immunology, School of Medicine, Kyungpook National University) ;
  • Gyoonhee, Han (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University) ;
  • Soung-Hoon, Lee (CK Regeon Inc., Engineering Research Park) ;
  • Kang-Yell, Choi (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University)
  • Received : 2022.05.06
  • Accepted : 2022.08.02
  • Published : 2022.11.30

Abstract

Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/β-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice. In diabetic mice, both hair regrowth and wound-induced hair follicle neogenesis (WIHN) were reduced because of suppression of Wnt/β-catenin signaling and decreased proliferation of hair follicle cells. We identified that KY19382, a small molecule that activates Wnt/β-catenin signaling, restored the capabilities of regrowth and WIHN in diabetic mice. The Wnt/β-catenin signaling activator also increased the length of the human hair follicle which was decreased under high glucose culture conditions. Overall, the diabetic condition reduced both hair regrowth and regeneration with suppression of the Wnt/β-catenin signaling pathway. Consequently, the usage of Wnt/β-catenin signaling activators could be a potential strategy to treat diabetes-induced alopecia patients.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (2019R1A2C3002751, 2020M3E5E2040018). Y.C RYU was supported by a Brain Korea 21 (BK21) FOUR studentship from the NRF.

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