대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제43권6호
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  • Pages.409-416
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  • 2022
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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레이저 조사 전후 자궁경부조직의 상대적 전기물성 스펙트럼 변화를 이용한 자궁경부 이형성증 치료검증도구의 가능성 평가

Feasibility Study of a Verification Tool for the Treatment of Cervical Intraepithelial Neoplasia Using Relative Electrical Property Change Before and After Laser Irradiation

  • 허준범 (경희대학교 의과대학 의공학교실) ;
  • ;
  • 오동인 (경희대학교 의과대학 의공학교실) ;
  • 박동춘 (카톨릭대학교 성빈센트병원 산부인과)
  • Jun Beom, Heo (Department of Biomedical Engineering, College of Medicine, Kyung Hee University) ;
  • Tingting, Zhang (Department of Biomedical Engineering, College of Medicine, Kyung Hee University) ;
  • Tong In, Oh (Department of Biomedical Engineering, College of Medicine, Kyung Hee University) ;
  • Dong Choon, Park (Department of Obstetrics and Gynecology, Saint Vincent's Hospital, The Catholic University of Korea)
  • 투고 : 2022.11.17
  • 심사 : 2022.12.06
  • 발행 : 2022.12.31
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초록

Since the detection of cervical intraepithelial neoplasia (CIN) is increasing due to regular cervical cancer screening, there is a high demand for simpler tools to diagnose and treat CIN in the clinic. In this study, we proposed an electric property of cervical tissue to verify treatment using a laser. At first, we observed the depth and width of ablated cervical tissues for 29 samples according to four different pulse energy of the fractional CO2 laser to find enough pulse energy to reach the basement layer for initiated CIN. And then, the relative frequency differences in impedance spectrum before and after laser irradiation for ten non-CIN samples were collected using bioimpedance spectroscopy with a multi-electrode probe. As a result, the laser ablated the cervical tissues with a depth of more than 300 ㎛ at 100 mJ pulse energy. Also, we confirmed that the relative changes of electrical property for cervical tissue increased as the pulse energy of laser output increased, and the variation between samples decreased. Since the relative change in electrical properties of cervical tissue can be easily and quickly measured, the proposed technique paves the way for further verification and follow-up study of laser treatment for CIN.

키워드

과제정보

본 연구는 한국연구재단을 통해 과학기술정보통신부의 사업(NRF-2019R1A2C1086807, NRF-2020R1A2C1008975)과 교육부 사업(NRF-2020R1I1A1A01066649), 성빈센트병원 임상의학연구소 과제(VC20TISI0072)로부터 지원을 받아 수행하였음.

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