Journal of Acupuncture Research

  • 제38권4호
  • /
  • Pages.293-299
  • /
  • 2021
  • /
  • 2586-288X(pISSN)
  • /
  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
권호 표지
DOI QR코드

DOI QR Code

Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice

  • Park, Jin Woo (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University) ;
  • Song, Ho-Sueb (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University)
  • 투고 : 2021.07.27
  • 심사 : 2021.08.18
  • 발행 : 2021.11.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD). Methods: Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agents, and evidence of antioxidant activity were examined in PA treated mice (n = 3), PA-AST treated mice (n = 3), and a control group of mice (n = 3). This included measurements of ear thickness, levels of mast cells, IgE, inflammatory cytokine, malondialdehyde (MDA), hydrogen peroxide, HO-1, and GPx-1. Results: AST treatment significantly prevented inflammation as measured by ear thickness (p < 0.05), mast cell count (p < 0.001), and IgE concentration in the blood (p < 0.001). Levels of TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), and MDA (p < 0.05) were also significantly lower. In addition, GSH levels increased significantly (p < 0.001), and the level of hydrogen peroxide significantly reduced (p < 0.01). The expression of HO-1, GPx-1 increased. Conclusion: In this small experimental study, AST acted on inflammatory mechanisms that induced AD, through anti-inflammatory and antioxidant mechanisms, and is a candidate of interest in the clinical treatment of AD.

키워드

참고문헌

  1. Leung DYM, Bieber T. Atopic dermatitis. Lancet 2003;361:151-160. https://doi.org/10.1016/S0140-6736(03)12193-9
  2. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733-743. https://doi.org/10.1016/S0140-6736(06)69283-0
  3. Lopez Carrera YI, Al Hammadi A, Huang YH, Llamado LJ, Mahgoub E, Tallman AM. Epidemiology, Diagnosis, and Treatment of Atopic Dermatitis in the Developing Countries of Asia, Africa, Latin America, and the Middle East: A Review. Dermatol Ther 2019;9:685-705. https://doi.org/10.1007/s13555-019-00332-3
  4. Kobusiewicz A, Zalewska-Janowska AM, Lesiak A, Narbutt J. Management of severe atopic dermatitis in adult patients. Przeglad Dermatologiczny 2020;107:234-245.
  5. Coondoo A, Phiske M, Verma S, Lahiri K. Side-effects of topical steroids: A long overdue revisit. Indian Dermatol Online J 2014;5:416-425. https://doi.org/10.4103/2229-5178.142483
  6. Thyssen JP, Rinnov MR, Vestergaard C. Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors. Acta Derm Venereol 2020;100:341-348.
  7. Jiang MZ, Tsukahara H, Ohshima Y, Sato S, Todoroki Y, Hiraoka M et al. Effects of Antioxidant and Nitric Oxide on Chemokine Production in TNF-a-stimulated Human Dermal Microvascular Endothelial Cells. Life Sci 2004;75:1159-1170. https://doi.org/10.1016/j.lfs.2004.01.031
  8. Devadasan S, Sarkar R, Barman KD, Kaushik S. Role of Serum Melatonin and Oxidative Stress in Childhood Atopic Dermatitis: A Prospective Study. Indian Dermatol Online J 2020;11:925-929. https://doi.org/10.4103/idoj.IDOJ_77_20
  9. Maintz L, Novak N. Modifications of the innate immune system in atopic dermatitis. J Innate Immun 2011;3:131-141. https://doi.org/10.1159/000323963
  10. Sivaranjani N, Venkata RAO S, Rajeev G. Role of Reactive Oxygen Species and Antioxidants in Atopic Dermatitis. J Clin Diagn Res 2013;7:2683-2685.
  11. Lorenz RT, Cysewski GR. Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol 2000;18:160-167. https://doi.org/10.1016/S0167-7799(00)01433-5
  12. Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 2003;21:210-216. https://doi.org/10.1016/S0167-7799(03)00078-7
  13. Lee YS, Jeon SH, Ham HJ, Lee HP, Song MJ, Hong JT. Improved Anti-Inflammatory Effects of Liposomal Astaxanthin on a Phthalic Anhydride-Induced Atopic Dermatitis Model. Front Immunol 2020;11:565285. https://doi.org/10.3389/fimmu.2020.565285
  14. Naguib Y, Gazella KA. Nature's Super Antioxidant. Total Health 2000;22:36-37.
  15. Nakajima Y, Inokuchi Y, Shimazawa M, Otsubo K, Ishibashi T, Hara H, Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo. J Pharm Pharmacol 2008;60:1365-1374. https://doi.org/10.1211/jpp/60.10.0013
  16. Yoshihisa Y, Andoh T, Matsunaga K, Ur Rehman M, Maoka T, Shimizu T. Efficacy of astaxanthin for the treatment of atopic dermatitis in a murine model. PLoS ONE 2016;11:e0152288. https://doi.org/10.1371/journal.pone.0152288
  17. Meephansan J, Trakanwittayarak S, Pootongkam S, Thaiwat S. Astaxanthin effect on the elicitation of allergic contact dermatitis to hair dye containing p-phenylenediamine. J Dermatol Nurses Assoc 2020;12:2.
  18. Choo WT, Teoh ML, Phang SM, Convey P, Yap WH, Goh BH, Beardall J. Microalgae as Potential Anti-Inflammatory Natural Product Against Human Inflammatory Skin Diseases. Front Pharmacol 2020;11:1086. https://doi.org/10.3389/fphar.2020.01086
  19. Park JH,Yeo IJ,Han JH,Suh JW, Lee HB, Hong JT. Anti-inflammatory effect of astaxanthin in phthalic anhydride induced atopic dermatitis animal model. Exp Dermatol 2018;27:378-385. https://doi.org/10.1111/exd.13437
  20. Lee YS, Lee CH, Bae JT, Nam KT, Moon DB, Hwang OK et al. Inhibition of skin carcinogenesis by suppression of NF-κB dependent ITGAV and TIMP1 expression in IL-32γ overexpressed condition. J Exp Clin Cancer Res 2018;37:293. https://doi.org/10.1186/s13046-018-0943-8
  21. Na CH, Baghoomian W, Simpson EL. A Therapeutic Renaissance - Emerging Treatments for Atopic Dermatitis. Acta Derm Venereol 2020;100:367-379.
  22. Grobe W, Bieber T, Novak N. Pathophysiology of atopic dermatitis. J German Soc Dermatol 2019;17:433-440.
  23. Kim JE, Kim HS. Microbiome of the skin and gut in atopic dermatitis (Ad): Understanding the pathophysiology and finding novel management strategies. J Clin Med 2019;8:444. https://doi.org/10.3390/jcm8040444
  24. Khan SMA, Sethi B, Malik N, Anwar I. Awareness regarding protective measures against side effects following long term corticosteroid therapy. Pakistan J Surg 2019;35:44-48.
  25. Rotaru M, Iancu GM, Matran IM. Importance of food in the control of inflammation in atopic dermatitis. Exp Ther Med 2020;20:206.
  26. Kwon CY, Lee BR, Kim SR, Lee JS, Park MJ, Kim NK. Effectiveness and Safety of Herbal Medicine for Atopic Dermatitis: An Overview of Systematic Reviews. Evid Based Complement Alternat Med 2020;2020:4140692.
  27. Chawla A, Nguyen KD, Goh YPS. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immun 2011;11:738-749. https://doi.org/10.1038/nri3071
  28. Kidd P. Astaxanthin, Cell Membrane Nutrient with Diverse Clinical Benefits and Anti-Aging Potential. Altern Med Rev 2011;16:355-364.
  29. Aruoma OI, Grootveld M, Bahorun T. Free Radicals in Biology and Medicine: From Inflammation to Biotechnology. Biofactors 2006;27:1-3. https://doi.org/10.1002/biof.5520270101
  30. Rivest S. Activation of the nuclear factor kappa B (NF- kB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation. Mol Psychiatry 1999;4:500 https://doi.org/10.1038/sj/mp/4000679
  31. Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol 2006;126:2565-2575. https://doi.org/10.1038/sj.jid.5700340
  32. Nakanishi M, Rosenberg D. Multifaceted roles of PGE in inflammation and cancer. Semin Immunopathol 2013;35:123-137. https://doi.org/10.1007/s00281-012-0342-8
  33. Cherian DA, Peter T, Narayanan A, Madhavan SS, Achammada S, Vynat GP. Malondialdehyde as a Marker of Oxidative Stress in Periodontitis Patients. J Pharm Bioallied Sci 2019;11:S297-S300.
  34. Kabel AM. Free radicals and antioxidants: role of enzymes and nutrition. World J Nutr Health 2014;2:3538.