References
- Ahn, N.G. 2015. Changes in chemical composition during red ginseng manufacturing process. Department of Food Engineering, MS Thesis, Kongju National Univ., Korea (in Korean).
- Akao, T., Kida. H, Kanaoka. M, Hattori. M and Kobashi. K. 1998. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng. J. Pharm. Pharmacol. 50:1155-1160. https://doi.org/10.1111/j.2042-7158.1998.tb03327.x
- Cho, J.Y. 2009. Immuno-regulatory efficacy or red ginseng derived ingredients. Food Preservation and Processing Industry. pp. 6-12 (in Korean).
- Choi, J.H., W.J. Kim, J.W. Yang, H.S. Sung and S.K. Hong. 1981. Variation of ginseng extract by heat treatment. J. Korean Agricultural Chemical Society 24(1):50-58 (in Korean).
- Choi, J.W., M.J. Oh, S.K. Ha, Y. Park and H.Y. Park. 2016. Characterization and optimization for beverage manufacture using Korea red ginseng extract. Korean Journal of Food Preservation and Processing Industry 23(3):319-325. https://doi.org/10.11002/kjfp.2016.23.3.319
- Choi, S.Y., J.S. Park, C.H. Shon, C.Y. Lee, J.M. Ryu, D.J. Son, B.Y. Hwang, H.S. Yoo, Y.C. Cho, J. Lee, J.W. Kim and Y.S. Roh. 2019. Fermented Korean red ginseng extract enriched in Rd and Rg3 protects against non-alcoholic fatty liver disease through regulation of mTORC1. Nutrients 11:2963. https://doi.org/10.3390/nu11122963
- Hasegawa, H., K.S. Lee, T. Nagaoka, Y. Tezuka, M. Uchiyama, S. Kakota and S. Ikuo. 2000. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters. Biol. Pharm. Bull. 23(3)298-304. https://doi.org/10.1248/bpb.23.298
- Her, Y., Y.C. Lee, J.H. Oh, Y.E. Choi, C.W. Lee, J.S. Kim, H.M. Kim and J.W. Yang. 2012. An application of β-glycosidase to transformation of ginsenosides for the effective production of specific ginsenosides with biological efficacy. Biotechnol. Bioprocess Eng. 17:538-546. https://doi.org/10.1007/s12257-011-0678-2
- Kim, H.I., J.K. Kim, J.Y. Kim, M.J. Han and D.H. Kim. 2018. Fermented red ginseng and ginsenoside Rd alleviate ovalbumin-induced allergic rhinitis in mice by suppressing IgE, interleukin-4, and interleukin-5 expression. J. Ginseng Res. 43(4):635-644. https://doi.org/10.1016/j.jgr.2019.02.006
- Kim, J.H., Y.S. Kim, M.Y. Kim and J.Y. Cho. 2017. Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases. J. Ginseng Res. 41: 435-443. https://doi.org/10.1016/j.jgr.2016.08.004
- Kim, J.K., J.Y. Kim, S.E. Jang, M.S. Choi, H.M. Jang, H.H. Yoo and D.H. Kim. 2018. Fermented red ginseng alleviates cyclophosphamide-induced immunosuppression and 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by regulation macrophage activation and T cell differentiation. Am. J. Chin. Med. 48(8):1879-1897.
- Kim, J.K., M.S. Choi, W.H. Jeung, J. Ra, H.H. Yoo and D.H. Kim. 2019. Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng. J. Ginseng Res. 44(4):611-618. https://doi.org/10.1016/j.jgr.2019.05.012
- Kim, K.A., H.H. Yoo, G. Wang, D.H. Yu, M.J. Jin, H.L. Choi, K.Y. G.D. Laetitia and D.H. Kim. 2015. A prebiotic fiber increases the formation and subsequent absorption of compound K following oral administration of ginseng in rats. J. Ginseng Res. 39:183-187. https://doi.org/10.1016/j.jgr.2014.11.002
- Kim, S.C., C.E. Hwang, B.O.L. Kim, K.H. Lee, J.H. Lee, K.M. Cho and O.S. Joo. 2021. Comparison of ginsenoside (Rg1, Rb1) content and radical-scavenging activities of wild-simulated ginseng extract with respect to the solvent. Korea J. Food Preserv. 28(2):261-269. https://doi.org/10.11002/kjfp.2021.28.2.261
- Ko, S.K., C.R. Lee, Y.E. Choi, B.Ok. Im, J.H. Sung and K.R. Yoon. 2003. Analysis of ginsenosides of white and red ginseng concentrates. Korean J. Food Sci. Technol. 35(3):536-539.
- Lee, G.S., K.Y. Nam and J.E. Choi. 2013. Ginsenoside composition and quality characteristics of red ginseng extracts prepared with different extracting methods. Korean J. Medicinal Crop. Sci. 21(4):276-281 https://doi.org/10.7783/KJMCS.2013.21.4.276
- Lee, S.J., Y. Kim and M.G. Kim. 2015. Changes in the ginsenoside content during the fermentation process using microbial strains. J Ginseng Res. 39(4):392-397. https://doi.org/10.1016/j.jgr.2015.05.005
- Li, X., J.S. Han, Y.J. Park, S.J. Kang, J.S. Kim, K.Y. Nam, K.T. Lee and J.E. Choi. 2009. Extracting conditions for promoting ginsenoside contents and taste of red ginseng water extract. J. Crop Sci. 54:287-293.
- Nam, K.Y and D.C. Yang. 2009. The main ingreadients and efficacy of Koryeo red ginseng. Korean J. Plant Resources 16(1):33-39 (in Korean).
- Park, H. 2019. The role of gut microbiota in ginsenoside meta-bolism and biotransformatino of ginsenoside by lactic acid bacteria. 2019. Curr. Top. Lact. Acid Bact. Probiotics 5(1):1-12. https://doi.org/10.35732/ctlabp.2019.5.1.1
- Saba, E., D. Jeong, M. Irfan, Y.Y. Lee, S.J. Park, C.K. Park and M.H. Rhee. 2018. Anti-inflammatory activity of Rg3-enriched Korean red ginseng extract in murine model of sepsis. Evid. Based Complement. Alternat. Med. 2018:6874692.
- Shim, J.S., G.G. Park and Y.S. Park. 2014. Bioconversion of puffed red ginseng extract using β-glucosidase-producing lactic acid bacteria. Food Eng. Prog. 18(4):332-340. https://doi.org/10.13050/foodengprog.2014.18.4.332
- Trinh, H.T. 2011. Intestinal microflora enhance the anti-pruritic activities of several glycosides from herbal medicines. Department of Pharmacy, Ph.D. Thesis, Kyeonghee Univ., Korea.
- U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) (U.S.FDA). 2005. Guidance for industry estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. USA. pp. 1-27.
- Wakabayashi, C., H. Hasegawa, J. Murata, and I. Saiki. 1997. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 9:411-417.
- Zhang, X., S. Chen, F. Duan, A.L. Shaojing, L.W. Zhong, W. Sheng, J. Che, J. Xu and S. Xiao. 2020. Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota. J. Ginseng Res. 45(2): 334-343.