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Beam-scanning Imaging Needle for Endoscopic Optical Coherence Tomography

  • Received : 2021.05.25
  • Accepted : 2021.07.21
  • Published : 2021.10.25

Abstract

We present a compact endoscopic probe in a needle form which has a fast beam-scanning capability for optical coherence tomography (OCT). In our study, a beam-scanning OCT imaging needle was fabricated with a 26G syringe needle (0.46 mm in outer diameter) and a thin OCT imaging probe based on the stepwise transitional core (STC) fiber. The imaging probe could freely rotate inside the needle for beam scans. Hence, OCT imaging could be performed without rotation or translation of the needle body. In our design, the structural integrity of the needle's steel tubing was preserved for mechanical robustness. Probing the optical signal was performed through the needle's own window formed at the end. For hand-held operation of our imaging needle, a light and compact scanner module (130 g and 45 × 53 × 60 mm3) was devised. Connected to the imaging needle, it could provide rotational actuation driven by a galvanometer. Because of its finite actuation range, our scanner module did not need a fiber rotary joint which might add undesirable complexity. The beam scan speed was 20 Hz and supported 20 frames per second at the maximum for endoscopic OCT imaging.

Keywords

Acknowledgement

This study was supported by National Research Foundation of Korea (NRF-2018R1D1A1B07045449, NRF-2021R1A2C1004526).

References

  1. X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, "Imaging needle for optical coherence tomography," Opt. Lett. 25, 1520-1522 (2000). https://doi.org/10.1364/OL.25.001520
  2. D. Lorenser, R. A. McLaughlin, and D. D. Sampson, "Optical coherence tomography in a needle format," in Optical Coherence Tomography: Technology and Applications, W. Drexler, J. G. Fujimoto, Eds. (Springer, Cham, Switzerland. 2015), pp. 2413-2472.
  3. B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, D. D. Sampson, and P. B. Noble, "In situ imaging of lung alveoli with an optical coherence tomography needle probe," J. Biomed. Opt. 16, 036009 (2011). https://doi.org/10.1117/1.3556719
  4. R. A. McLaughlin, B. C. Quirk, A. Curatolo, R. W. Kirk, L. Scolaro, D. Lorenser, P. D. Robbins, B. A. Wood, C. M. Saunders, and D. D. Sampson, "Imaging of breast cancer with optical coherence tomography needle probes: feasibility and initial results," IEEE J. Sel. Top. Quantum Electron. 18, 1184-1191 (2012). https://doi.org/10.1109/JSTQE.2011.2166757
  5. R. A. McLaughlin, X. Yang, B. C. Quirk, D. Lorenser, R. W. Kirk, P. B. Noble, and D. D. Sampson, "Static and dynamic imaging of alveoli using optical coherence tomography needle probes," J. Appl. Physiol. 113, 967-974 (2012). https://doi.org/10.1152/japplphysiol.00051.2012
  6. N. Iftimia, J. Park, G. Maguluri, S. Krishnamurthy, A. McWatters, and S. H. Sabir, "Investigation of tissue cellularity at the tip of the core biopsy needle with optical coherence tomography," Biomed. Opt. Express 9, 694-704 (2018). https://doi.org/10.1364/BOE.9.000694
  7. M. S. Jafri, S. Farhang, R. Tang, N. Desai, P. S. Fishman, R. G. Rohwer, C.-M. Tang, and J. M. Schmitt, "Optical coherence tomography in the diagnosis and treatment of neurological disorders," J. Biomed. Opt. 10, 051603 (2005). https://doi.org/10.1117/1.2116967
  8. K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, "Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance," Biomed. Opt. Express 3, 1947-1954 (2012). https://doi.org/10.1364/BOE.3.001947
  9. S. Shin, J. K. Bae, Y. Ahn, H. Kim, G. Choi, Y.-S. Yoo, C.-K. Joo, S. Moon, and W. Jung, "Lamellar keratoplasty using position-guided surgical needle and M-mode optical coherence tomography," J. Biomed. Opt. 22, 125005 (2017).
  10. Y.-S. Yoo, W.-J. Whang, M.-J. Kang, J.-H. Hwang, Y.-S. Byun, G. Yoon, S. Shin, W. Jung, S. Moon, and C.-K. Joo, "Effect of air injection depth on big-bubble formation in lamellar keratoplasty: an ex vivo study," Sci. Rep. 9, 3785 (2019). https://doi.org/10.1038/s41598-018-36522-w
  11. B. C. Quirk, R. A. McLaughlin, A. M. Pagnozzi, B. F. Kennedy, P. B. Noble, and D. D. Sampson, "Optofluidic needle probe integrating targeted delivery of fluid with optical coherence tomography imaging," Opt. Lett. 39, 2888-2891 (2014). https://doi.org/10.1364/OL.39.002888
  12. J. Li, E. Schartner, S. Musolino, B. C. Quirk, R. W. Kirk, H. Ebendorff-Heidepriem, and R. A. McLaughlin, "Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue," Opt. Lett. 43, 1682-1685 (2018). https://doi.org/10.1364/OL.43.001682
  13. M. J. Gora, M. J. Suter, G. J. Tearney, and X. Li, "Endoscopic optical coherence tomography: technologies and clinical applications," Biomed. Opt. Express 8, 2405-2444 (2017). https://doi.org/10.1364/BOE.8.002405
  14. J. Lee, Y. Chae, Y.-C. Ahn, and S. Moon, "Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber," Biomed. Opt. Express. 6, 1782-1796 (2015). https://doi.org/10.1364/BOE.6.001782
  15. S. Moon, Z. Piao, C.-S. Kim, and Z. Chen, "Lens-free endoscopy probe for optical coherence tomography," Opt. Lett. 38, 2014-2016 (2013). https://doi.org/10.1364/OL.38.002014
  16. D.-S. Kim and S. Moon, "Optimized working distance of a micro-optic OCT imaging probe," Curr. Opt. Photon. 4, 330- 335 (2020). https://doi.org/10.3807/COPP.2020.4.4.330
  17. W. Jung, W. A. Benalcazar, A. Ahmad, U. Sharma, H. Tu, and S. A. Boppart, "Numerical analysis of gradient index lens-based optical coherence tomography imaging probes," J. Biomed. Opt. 15, 066027 (2010). https://doi.org/10.1117/1.3523374