Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Effect of Crosslinking Agent Structure on Drug Release and Antibacterial Effect of Contact Lenses

교차결합제 구조가 콘택트렌즈의 약물용출 및 항균효과에 미치는 영향

  • Lee, Pil-Heon (Department of Optometry & Vision Science, Daegu Catholic University) ;
  • Lee, Hyun Mee (Department of Optometry & Vision Science, Daegu Catholic University)
  • 이필헌 (대구가톨릭대학교 안경광학과) ;
  • 이현미 (대구가톨릭대학교 안경광학과)
  • Received : 2021.07.07
  • Accepted : 2021.07.29
  • Published : 2021.10.20
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Abstract

This study investigated the effect of the structure of the crosslinking agent used in contact lens polymerization on the physical properties and drug dissolution of contact lenses.es Contact lenses were manufactured using 0.3% and 3% of 4 types of crosslinking agents, respectively, and ofloxacin was used as the drug. Contact lenses using hydrophilic crosslinking agents improved water contents and wettability, and the more hydrophilic functional groups, the greater the effect. Contact lenses with a high concentration of crosslinking agent had a low concentration of eluted drug and a longer release time. The cross-linking agent structure of contact lenses had an effect on improving the performance of contact lenses and controlling drug release.

본 연구는 콘택트렌즈를 중합 시 사용하는 교차결합제의 구조가 콘택트렌즈의 물리적 특성 및 약물 용출에 미치는 영향을 조사하였다. 4종의 교차결합제를 0.3%와 3%를 각각 사용하여 콘택트렌즈를 제작하였으며 약물은 안약에 사용하는 ofloxacin을 사용하였다. 친수성 교차결합제를 사용한 콘택트렌즈는 함수율과 습윤성이 향상되었으며 친수성 작용기가 많을수록 효과가 크게 나타났다. 약물용출 농도는 친수성이 강한 교차결합제 사용 시 가장 높게 나타났으며 교차결합제의 농도가 높은 콘택트렌즈는 용출되는 약물 농도가 낮고 용출시간은 길어졌다. 콘택트렌즈의 교차결합제 구조는 콘택트렌즈의 성능 향상과 약물 방출조절에 영향을 주었다.

Keywords

Acknowledgement

This work was supported by research grants from Daegu Catholic University in 2019.

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