Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Influence of Glycyrrhizic Acid, Menthol and Their Supramolecular Compounds on the Functional Activity of Rat Mitochondria in in-vitro Experiments

  • Ettibaeva, L.A. (Department of Chemistry, Gulistan State University) ;
  • Abdurahmonova, U.K. (Department of Chemistry, Gulistan State University) ;
  • Matchanov, A.D. (Experimental Technology Laboratory, Acad. O. Sodiqov Institute of Bioorganic Chemistry) ;
  • Allanazarova, D.M. (Department of Chemistry, Gulistan State University) ;
  • Halmuratova, Z.T. (Department of Сhemistry, Qaraqalpaq State University)
  • Received : 2021.05.04
  • Accepted : 2021.06.23
  • Published : 2021.10.20
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Abstract

Menthol (M) is a cyclic monoterpenode and is a major component of essential oils. Menthol, along with menthol, isomenton, etc., gives taste and odor of the mint plant, and when it comes to menthol in general, L- or (-) -menthol is usually used. Included in pharmaceuticals, cosmetics and pesticides. It has antimicrobial, antibacterial, antioxidant properties. It is also known that the licorice plant (Glycyrrhiza Glabra L.) differs from other types of plants by its medicinal properties. For many years it has been used in folk medicine. Extraction of licorice root revealed up to 25% glycyrrhizinic acid (GA). Its aglycone - glycyrrhizic acid is notable for its structural similarity to the adrenal cortex hormones. Currently, GA and glycyrrhizic acid are widely used in medicine as a remedy for colds, allergies, viral diseases, tumors. The biological activity of menthol and GA-based supramolecular compounds has been poorly studied, and their effect on the functional parameters of rat liver mitochondria has been studied little. For this purpose, in our experiments, the effect of menthol (M), glycyrrhizinic acid (GA) and their supramolecular complexes obtained in different proportions on in vitro and in vivo studies on rat liver mitochondria was studied.

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Acknowledgement

Publication cost of this paper was supported by the Korean Chemical Society.

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